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Azelo_tds

AZELOGLICINA
(INCI Name: Potassium Azelaoyl Diglycinate)
INTRODUCTION:
CLINICAL TESTING:
Azelaic Acid is a naturally occurring
BIOACTIVITY
Independent testing of AZELOGLICINA
4) found in whole grain cereals and animal evaluate its activity in three areas of interest thetically produced by the action of nitric acid oxidation (hence the ‘aze-‘ prefix) on oleic or elaidic acid. This organic acid dis- ♦ Sebum Normalization
plays bacteriostatic and bactericidal proper- the production of cutaneous lipids on the and has FDA approval for the treatment of mild to moderate inflammatory acne vul- garis. Azelaic acid is also used by derma-
Skin Lightening
mented skin and shows effectiveness in the measurements (3.2% for “spots”, 5.4% on treatment of various forms of androgenetic alopecia and other types of hair loss. Although Azelaic Acid has significant
Moisturization and Re-Hydration
Significant increases in Skin Hydra-
industrial uses and increasing application in tion values (forehead = 12.7%; cheek =
professional medical treatment, it has found 8.2%) and Skin Elasticity (R9 parameter,
little if any use in cosmetic and personal care formulations primarily due to its low water solubility and skin and eye irritation TOXICOLOGY
AZELOGLICINA , the mono-
potassium salt of azelaic acid diglyci-
nate, maintains many of the useful proper-
ties of the parent compound but displays CHEMICAL STRUCTURE:
greater water solubility and improved toxi- cology. When used in creams and lotions at the 5 – 10% level (as received), AZELO-
GLICINA has been shown to be an effective
and mild skin-lightening agent, to control the production of sebum and to confer anti- aging effects through the moisturization and AMITECH, INC.
Tele: (908) 453-3743 FAX: (908) 453-3645 Email: ami_inc2000@aol.com
AZELOGLICINA
(Potassium Azelaoyl Diglycinate)
COMPARING
AZELOGLICINA
and AZELAIC ACID
AZELOGLICINA is an improved form of azelaic acid, delivering many of
the benefits of the parent compound while minimizing the negative aspects. The table below compares the properties of both materials: PROPERTY
AZELAIC ACID
AZELOGLICINA
Appearance/Form
Water Solubility
Toxicity
Skin Lightening
Sebum Control
Moisturization\
Rehydration Applications

TYPICAL PROPERTIES
FORMULATING with
AZELOGLICINA
Appearance: Clear liquid
Color: Colorless
Odor: Odorless
rapid miscibility of AZELO-
pH (as is): 6.5 – 7.5
Density: 1.165 g/ml
GLICINA in water, it is easily incor-
Proteic Nitrogen:
Activity: 28 – 32 %
Use Levels:
pages, the AZELOGLICINA is nor-
Preservation:
AZELOGLICINA
(Potassium Azelaoyl Diglycinate)
FORMULATING WITH AZELOGLICINA
FORMULA 1 NONIONIC CLEAR GEL for OILY SKIN
This simple and elegant serum-like clear gel demonstrates the use of AZELOGLICINA in a leave-on
sebum control formulation

INGREDIENTS wt %
PREPARATION
2 GRAMBEN II 1 0.90
(Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben) AZELOGLICINA followed by the
citric acid. Add the guar deriva-
tive in increments until it is com-
5 AZELOGLICINA 1 5.00
(Potassium Azelaoyl Diglycinate) 1 – SINERGA/AMITECH
FORMULA 2 REHYDRATING ANIONIC O/W EMULSION
A high quality yet easy to prepare rehydrating/moisturizing emulsion that applies uniformly and leaves INGREDIENTS wt %
PREPARATION
1 PHYTOCREAM 1 10.00
AZELOGLICINA and SEAMOL-
Wheat Protein (and) Glyceryl Stearate LIENT. Warm to 55oC.
PHENOXYPARABEN and warm to
55oC. Add the PHYTOCREAM to
5 PHENOXYPARABEN 1 0.50
(Phenoxethanol (and) Methylparaben Propylparaben (and) Butylparaben AZELOGLICINA 5.00
(Potassium Azelaoyl Diglycinat e) 7 SEAMOLLIENT 1 5.00

1 – SINERGA/AMITECH
AZELOGLICINA
(Potassium Azelaoyl Diglycinate)
FORMULA 3
VERY LOW VISCOSITY SPRAYABLE EMULSION
This very low viscosity emulsion is especially designed to be used as e ither an after- bath body splash or spray. The AZELOGLICINA provides and maintains mosturization INGREDIENTS wt %
REPARATION
1 Glyceryl Stearate (and) Ceteareth - 20 4.50 (and) Ceteareth -12 (and) Cetearyl Alcohol (and) Cetyl Palmitate 2 AZELOGLICINA
2 Cetearet h - 20 1.50 GRAM 1 under high shear.
3 Dicapryl Ether 5.00 PHENOXYPARABEN 1
(Phenoxethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben) 8 GRAM 1 1 0.30
6 AZELOGLICINA 1 5.00
(Potassium Azelaoyl Diglycinate) SINE
RGA/AMITECH
EMULGADE SE ex
HENKEL
FORMULA 4O/A NONIONIC EMULSION
A classic and simple nonionic emulsion for oily skin. INGREDIENTS wt %
1 (Cetearyl Glucoside 5.00 PREPARATION
5 PHENOXYPARABEN 1 0.50
(Phenoxethanol (and) Methylparaben order 1,2,5 and finally the AZE-
LOGLICINA. Continue stirring
Propylparaben (and) Butylparaben) 6 AZELOGLICINA1 5.00
(Potassium Azelaoyl Diglycinate)
1 – SINERGA/AMITECH
AMITECH, INC.
Tele: (908) 453-3743 FAX: (908) 453-3645 Email: ami_inc2000@aol.com

Source: http://www.amitech-usa.com/AMITECH%20PERSONAL%20CARE/PRODUCT%20FILES/SINERGA/AZELO/AZ_TDS/AZELO_TDS.PDF

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