Metformin Hydrochloride BP 500 mg & 850 mg Tablet
OBID (Metformin Hydrochloride) is an oral
trauma, injuries, infectious diseases, high fever, surgery,
antihyperglycaemic agent which improves glucose
lactic acidosis, radiological studies and excess alcohol
tolerance in patients with type-II diabetes. Metformin
Hydrochloride decreases hepatic glucose production,
decreases intestinal absorption of glucose and improves
USE IN PREGNANCY AND LACTATION
insulin sensitivity by increasing peripheral glucose
Metformin is not teratogenic in rats and rabbits at doses
uptake and utilization. Unlike sulfonylureas, metformin
up to 600 mg/kg/day. There are, however, no adequate
and well-controlled studies in pregnant women. Thus, it
is used during pregnancy only when the potential
COMPOSITION
benefits justify the possible risk to the foetus. Metformin
OBID 500 Tablet: Each film-coated tablet contains
is excreted into milk and reaches levels comparable to
those in plasma. So, it should not be taken during
OBID 850 Tablet: Each film-coated tablet contains
lactation without first talking to physician.
DRUG INTERACTION INDICATION
Nifedipine appears to enhance the absorption of
As monotherapy, metformin is indicated as an adjunct to
metformin. When thiazide and other diuretics,
diet and exercise to improve glycaemic control in
corticosteroids, phenothiazines, thyroid products, oral
patients with type-II diabetes. It may also be used
contraceptives, phenytoin, nicotinic acid,
concomitantly with a sulfonylurea or insulin to improve
sympathomimetics and calcium channel blockers are
glycaemic control in adults (17 years of age and older).
administered to a patient receiving metformin, the
patient should be closely observed to maintain adequate
DOSAGE AND ADMINISTRATION
The usual starting dose of metformin is 500 mg twice a
day or 850 mg once a day, given with meals. Dosage
PACKAGING
increases should be made up to a total of 3 gm per day.
OBID 500 Tablet: Box containing 10 x 10 tablets in
In maintenance therapy, the usual dose is 500 mg thrice
OBID 850 Tablet: Box containing 3 x 10 tablets in
CONTRAINDICATION
Metformin Hydrochloride is contraindicated in patients
PHARMACEUTICAL PRECAUTION
with renal disease or renal dysfunction, liver
Keep in a dry place away from light and heat.
impairment, congestive heart failure, lactic acidosis,
severe infection or trauma, dehydration, alcohol
dependence. It is also contraindicated in case of
hypersensitivity to metformin. It is contraindicated for paediatric use. SIDE EFFECT Diarrhoea, nausea, vomiting, flatulence and anorexia are the most common side effects of metformin. Lactic acidosis occurs rarely. PRECAUTION Metformin should only be prescribed when diet and weight reduction has proven inadequate. During concomitant therapy with other oral antihyperglycaemaic drugs, blood sugar should be monitored carefully. Caution should also be taken in the event of severe
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