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ObidMetformin Hydrochloride BP 500 mg & 850 mg Tablet OBID (Metformin Hydrochloride) is an oral trauma, injuries, infectious diseases, high fever, surgery, antihyperglycaemic agent which improves glucose lactic acidosis, radiological studies and excess alcohol tolerance in patients with type-II diabetes. Metformin Hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose and improves USE IN PREGNANCY AND LACTATION
insulin sensitivity by increasing peripheral glucose Metformin is not teratogenic in rats and rabbits at doses uptake and utilization. Unlike sulfonylureas, metformin up to 600 mg/kg/day. There are, however, no adequate and well-controlled studies in pregnant women. Thus, it is used during pregnancy only when the potential COMPOSITION
benefits justify the possible risk to the foetus. Metformin OBID 500 Tablet: Each film-coated tablet contains is excreted into milk and reaches levels comparable to those in plasma. So, it should not be taken during OBID 850 Tablet: Each film-coated tablet contains lactation without first talking to physician. DRUG INTERACTION
Nifedipine appears to enhance the absorption of As monotherapy, metformin is indicated as an adjunct to metformin. When thiazide and other diuretics, diet and exercise to improve glycaemic control in corticosteroids, phenothiazines, thyroid products, oral patients with type-II diabetes. It may also be used contraceptives, phenytoin, nicotinic acid, concomitantly with a sulfonylurea or insulin to improve sympathomimetics and calcium channel blockers are glycaemic control in adults (17 years of age and older). administered to a patient receiving metformin, the patient should be closely observed to maintain adequate DOSAGE AND ADMINISTRATION
The usual starting dose of metformin is 500 mg twice a day or 850 mg once a day, given with meals. Dosage PACKAGING
increases should be made up to a total of 3 gm per day. OBID 500 Tablet: Box containing 10 x 10 tablets in In maintenance therapy, the usual dose is 500 mg thrice OBID 850 Tablet: Box containing 3 x 10 tablets in CONTRAINDICATION
Metformin Hydrochloride is contraindicated in patients PHARMACEUTICAL PRECAUTION
with renal disease or renal dysfunction, liver Keep in a dry place away from light and heat. impairment, congestive heart failure, lactic acidosis, severe infection or trauma, dehydration, alcohol dependence. It is also contraindicated in case of hypersensitivity to metformin. It is contraindicated for
Diarrhoea, nausea, vomiting, flatulence and anorexia are
the most common side effects of metformin. Lactic
acidosis occurs rarely.
Metformin should only be prescribed when diet and
weight reduction has proven inadequate. During
concomitant therapy with other oral antihyperglycaemaic
drugs, blood sugar should be monitored carefully.
Caution should also be taken in the event of severe
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