of the European Society for Animal Cell Technology The 20th ESACT Meeting is approaching rapidly! meeting is raising a lot of interest, also with I respect to new membership. May I just for this reason welcome most warmly all the new completed and is available on the internet members who will receive this Newsletter for the Apart from five prominent keynote speakers and We - the "old" members are well aware that one ten invited speakers, approximately 35 oral strong motivation for you, the newcomers, to join contributions from submitted abstracts will be our society was the sharply discounted entry fee made. They were chosen by the Scientific for the most exciting cell culture technology Committee from all the submitted abstracts. meeting ahead of us. Dresden-ESACT, under the The trade exhibition – the largest and best known leadership of Dr. Hansjörg Hauser has assembled of its kind – again forms an integral part of this a program of top scientific quality, combined with ESACT meeting and promotes and underlines the a spectacular venue in one of the most attractive interaction among academic and industrial scientists. As in previous meetings, posters and I hope, however, that newcomers will be also a coffee breaks will be part of the trade exhibition, source of rejuvenation of ESACT and will provide providing excellent possibilities to interact. us with new ideas, both scientifically, but also with respect to the way how we try to keep ESACT on top of the needs and trends in animal cell culture technology. To make this quite clear to everybody: The work we - the members of the Executive Committee of ESACT - do, is not remunerated and we need new members of the ESACT community to eventually join in this effort. So again to the Newcomers - please fully Election of the Executive Committee 2007-2009 2 enjoy the upcoming meeting in Dresden, but also
try to find out what you can do for ESACT (!),
Contributions should be sent to eletter The European Society for Animal Cell Technolgy E u r o p e a n S o c i e t y f o r A n i m a l C e l l T e c h n o l o g y
Meanwhile, an area of 800 m2 has been allocated Registrations are still possible. Registration fee
to 74 exhibitors. Nevertheless, companies wishing (for ESACT members: 880 Euro) includes the to participate and be represented in the trade book of abstracts, a list of participants, a copy of exhibition are encouraged to contact the meeting the Meeting Proceedings (to be distributed in early organizer. The conference center offers further 2008), beverages during the coffee breaks, lunches from Monday-Wednesday, an excursion on Tuesday (June 19) and access to the conference A general assembly will be organized as in every dinner (ESACT Party) on Wednesday (June 20). meeting. It will take place at the conference center in Dresden during lunch time on Tuesday, June We are looking forward to an exciting and stimulating meeting and are inviting you wholeheartedly to join us at ESACT 2007 in The 2nd JIN Fair, a career consultancy forum directed towards students and recent graduates of the Animal Cell Technology field will also take On behalf of the Organizing, Scientific and place, organized by ESACT and run by the Consulting Firm Kleen Linnebo & Partner. Election of the Executive Committee 2007-2009 Online Election
Who can vote ?
his year ESACT has implemented an online All ESACT members who had a paid membership for electronic voting system for the Executive 2007 on April 30 (including honorary members) and T Committee elections. The feedback we have who have a correct and valid email in our records. received so far shows that the majority of our members If you belong to this category and have not received your voting code in the beginning of May, please The electronic voting system we are using guarantees contact us (admin, so that we check why anonymity. There is no way whatsoever for anybody (including the election administrators) to know who has voted for whom. How can I vote ?
As the new system is very easy to use (compared to the The complete instructions are detailed in the email you old partially paper-based system), we hope that have received in May. This email is important because members’ participation in the election process will it contains your registration code which is absolutely increase.
unique and can not be generated again. So if you are planning to vote when you will be in Dresden, after you have met the candidates, please be sure to bring your code with you. E u r o p e a n S o c i e t y f o r A n i m a l C e l l T e c h n o l o g y
I was given grants, presented my work through posters and talks and now my own students are attending the and enter your code in the blank field. And fill in your ESACT meetings. I was involved in the organization of the poster award in the Granada and Harrogate From there you can also give your feedback concerning the election process and this is anonymous In Harrogate (2005) I was elected member of the ESACT Executive Commite; since then I’ve been trying to serve the Animal Cell Technology Community and, in particular, to represent the ESACT OFFICERS FOR THE PERIOD 2007-2009
members and their wishes. Since I have enjoyed this (Appointed by the current Executive Committee) work I would like to continue and thus I am proposing myself as a candidate for the elections to the ESACT Chairman:
Florian M. Wurm
Committee that will be elected during the General Vice-Chairman: Martin Fussenegger
Dana Andersen
Alain Bernard
Dana Andersen is the Director of Early Stage Bioprocess Development at Genentech. He currently leads the departments responsible for developing the Secretary:
Stefanos Grammatikos
cell culture and purification processes for recombinant human therapeutic proteins and antibodies to support Research and early stage clinical development, and has over 11 years of experience at Genentech, primarily in Prior to joining Genentech, he performed post-doctoral research in the laboratory of J. Bailey at the ETH in Zürich and completed his Ph.D. work at Stanford Paula M. Alves
University, investigating the effects of cell culture factors on glycosylation in recombinant CHO cells. Born in 1967, Lisbon, Portugal. Received her B.Sc. in He is originally from Colorado and received his B.S. in chemical engineering from the University of Colorado Universidade do Lisboa (FCUL) in 1991 and her Ph.D. in Biochemistry at the Instituto de Tecnologia Química Motivation Statement
e Biológica, Universidade Nova de Lisboa in 2001. Group leader (2002-…) and Head of the Animal Cell I have greatly enjoyed and appreciated attending and Biotechnology Laboratory of IBET (2007-…), participating in numerous ESACT meetings and believe that this organization plays an important role in mammalian cell lines, primary cultures, co-cultures the advancement of the cell culture field. As a co- and immortalised cells as applied in brain cell culture organizer of the upcoming 2010 Cell Culture models, viral assembly, cell differentiation and Engineering meeting and the current chairman of the handling for regenerative medicine as well as American Chemical Society Division of Biochemical integration of bioreaction and downstream integration Technology’s Executive Committee, I hope to bring for biopharmaceuticals and vaccine development. Over perspective from these other parts of the cell culture fifty publications in refereed journals. community and to provide input to be sure that these organizations are complementary and aligned in Motivation Statement
serving the interests of the global cell culture Throughout the years since I started my Ph.D. work I community. I also believe that is critical to maintain have benefited enormously from ESACT's activities. strong, scientifically-driven meetings such as ESACT Attending meetings since 1991 (Brighton), I was kept provides, and will work to be sure that these meetings abreast of the newer developments in more mature and this organization play a key role in the areas at the same time as being given the opportunity development of the next generation of leaders in this to look out of the frame into areas of new opportunity, E u r o p e a n S o c i e t y f o r A n i m a l C e l l T e c h n o l o g y
John Bonham-Carter
Motivation Statement
After two media businesses in Montpellier, France, By serving on the Executive Committee I would be in and in London, I joined Adaptive Biosystems. I an excellent position to build bridges to the North became sales director with facility design & build American community in both Cell Culture and company WH Promation, before starting my own vaccines. This would further help to strengthen the company Magellan Instruments (UK & SE). In excellent conferences organized by ESACT. It would addition, I now work as European Sales Director for also help the Cell Culture community to act together internationally on issues of importance to our profession. My experience with organizing Cell Current activities: IChemE/BESG committee member; Culture Engineering twice and as Chair of Engineering ESACT 2009 conference; Nordic Bioprocess Network Conferences Foundation will help me to be an (NbiNet); previous co-organiser of conferences SCI Monitoring 2000, M3C 2002 and ESACT 2005. Motivation Statement
Francesc Gòdia
I aim to improve ESACT and the conference for all members. I will improve the conference back-office Professor of Chemical Engineering at Universitat organisation to help with the burden on the conference Autònoma de Barcelona, Spain. Research activity committee and reduce the financial risk to the society focused on the field of Biotechnology and Biochemical (both are serious issues in my view). I will improve Engineering, and more specifically in the culture of the finances of ESACT, with a goal of doubling the mammalian cells for the production of proteins with number of bursaries in 2009 from 2007. I will work to interest in diagnostic and therapy of diseases, and the increase the number of other benefits to members such cellular, metabolic and tissue engineering. Work in the development of industrial fermentation processes, immobilized biocatalysts, bioreactor design, and the development of biological life support systems for Barry C. Buckland
long term manned missions in Space. Co-founder of the spin-off company HEXASCREEN Culture PhD in Biochemical Engineering at University College Technologies, focused on the development of a London obtained in 1974. Joined the Merck Research laboratories (Rahway, NJ, USA) in 1980 and built a world class Bioprocess R&D group. Current position is Research Vice President of Bioprocess R&D. Became interested to contibute to ESACT since Leader of process development of all biologically attending his first ESACT meeting in 1992. Served on made product candidates within the MRL pipeline and the ESACT Executive Committee for several years, manufacture of Clinical Supplies during the past 20 and as Chairman of the 18th ESACT Meeting held in years. Products developed within this timeline include MEVACOR®, ZOCOR®, IVOMEC®, CANCIDAS®, President of the Spanish Society for Biotecnology from 2002 to 2006. Member of the Executive Board of the European Federation of Biotechnology since 2005. ZOSTAVAX® (shingles vaccine) and GARDASIL® (HPV vaccine). Motivation Statement
External awards and appointments include being I have enjoyed working for ESACT during a number elected to the National Academy of Engineering in of years, including organising General Meetings 1997 and Fellow of University College London in (Granada 2003), and I would like to keep contributing 1998. Chaired two International Conferences on Cell to and increasing the activities of our Society. Culture (Cell Culture Engineering IV and Cell Culture Particularly, in addition to the support I could provide Engineering V) and co-chaired the first three to future meetings organisers, I would like to explore International Conferences on Metabolic Engineering. the organisation of training activities on Animal Cell Co-Chaired the first International conference on Vaccine Technology (2006). Author or co-author of over 70 papers. Visiting Professor at University College London. E u r o p e a n S o c i e t y f o r A n i m a l C e l l T e c h n o l o g y
Hansjoerg Hauser
as involved in technical development of biologics from the Roche pipeline and of in-licensed product Head of the Division Molecular Biotechnology at the candidates. I have been active in the organization of Helmholtz Centre for Infection Research (formerly several ESACT, CCE and JAACT conferences and GBF) in Braunschweig, Germany. Graduated from the served as Roche representative to the Animal Cell University of Stuttgart-Hohenheim and the University of Konstanz. Doctoral degree received form the University of Konstanz in 1977. Worked as a Post-Doc Specific areas of technical expertise include: at the Max Planck Institute for Molecular Genetics, Baculovirus expression system, hydrodynamic stress, Berlin and at the German Cancer Centre, Heidelberg. metabolic flux analysis, on-line process monitoring In 1981 H. Hauser became Research Associate at the and control, and large-scale transient transfection. GBF. In 1982 he received an EMBO fellowship to Motivation Statement
work at the MRC-Institute in Mill Hill/London. In 1986 he started the research group "Genetics of My motivation to join the ESACT Executive Eukaryotes“. Since 1994 he is head of the department Committee is to help run and strenghten this for "Gene Regulation and Differentiation" and holds organization that has been invaluable to my work in his position as head of the Molecular Biotechnology the cell culture field and has provided for a network of Division since 1995. Teaches at the University of Oldenburg and at the Medical University of Hannover. Further, he is a visiting professor at the University of Lisbon and acts as a Scientific Advisor for several Hansjörg Hauser’s expertise is in molecular biology with emphasis on gene regulation in mammalian cells. His interests include gene regulation in the interferon Cell Technology for Cell Products
transcription activation and signal transduction that mediate consequences of infections, and translational research concerning gene expression in biotechnology and gene/cell therapies. He has published more that 150 papers and appears as inventor in a series of patents. Coordinator for several projects funded by Motivation Statement
highlight the novel capabilities of the industry to move the products towards the clinic Through membersip in the ESACT Executive and was attended by a wide range of workers in the Committee I wish to contribute to ESACT matters industry and for many it was their first ESACT with particular focus on the scentific orientation of the meeting. The meeting was started with a session on Society, organisational issues and advice for future Transcription to Secretion with a notable set of presentations on the emerging issues. The other sessions that followed Therapeutic Cell Engineering, Gene Medicine, Cells to Tissue, Protein products and Georg Schmid
Process Technology guided the delegates through the Having earned my Master's degree in Chemical Enginering at Universities of Karlsruhe and Leeds I biotechnology towards the industrial application of the entered the field of biotechnology with my PhD thesis products from cells. The meeting was supported by on Enzymatic Cellulose Degradation completed at the some exceptional invited speakers from around the Institute of Biotechnology at the Research Centre Jülich, Germany. I moved into cell culture research emerging technologies and the changes being made at through a post-doc position at the Chemical the industrial end of the ESACT spectrum. The Engineering Department of the University of proceedings here include the short papers adding the California, Berkeley. Upon returning to Europe I knowledge of the previous meetings and provide a worked for Behringwerke in Marburg before joining F. reference for the researcher entering, or continuing in Hoffmann-La Roche where I have been responsible for protein supply of numerous research projects as well E u r o p e a n S o c i e t y f o r A n i m a l C e l l T e c h n o l o g y
This book was recently distributed to all the optimizing bioreactor output has become a primary participants of the 19th ESACT meeting in Harrogate. concern for most pharmaceutical companies. Each If you wish to order it online, please visit the chapter in Cell Culture and Upstream Processing is “Proceedings” section of where you taken from presentations at the highly acclaimed IBC will find a direct link to the publisher. conferences as well as meetings of the European Society for Animal Cell Technology (ESACT) and Cell Culture and Upstream Processing
Protein Expression in Animal Cells (PEACe) and describes how to improve yield and optimise the cell culture production process for biopharmaceuticals, by focusing on safety, quality, economics and operability Publisher:Taylor and Francis.
Cell Culture and Upstream Processing will appeal to a practitioners of animal cell technology as well as genetically engineered to contain the human gene students of biochemical engineering or biotechnology which will express the protein of interest. The demand in graduate or high level undergraduate courses at for large quantities of specific proteins is increasing the pressure to boost cell culture productivity, and ESACT welcomes the following new members: Sandoz GmbH, Cell Culture Development Schaftenau Max Planck Institute for Cell Biology and Genetics E u r o p e a n S o c i e t y f o r A n i m a l C e l l T e c h n o l o g y
Executive Committee

Wurm Florian
Alves Paula Marques
Godia Francesc
Fussenegger Martin
Institute for Chemical and Bio-Engineering Merten Otto-wilhelm
Grammatikos Stefanos
stefanos.grammatikos Treasurer
Bernard Alain
Newsletter and General Management
Christophe Losberger
Meeting Chairman
Hauser Hansjorg
Bereichsleiter Molekulare Biotechnologie Helmholtz Zentrum für Infektionsforschung Inhoffenstr. 7 D - 38124 Braunschweig Germany Tel :



PROTOCOLO CLINICO DE LA PÉRDIDA GESTACIONAL PRECOZ RÉGIMEN MIFEPRISTONA-MISOPROSTOL PRIMERA VISITA Primer día -Explicar detenidamente a la paciente el proceso -Consentimientos informados - Analítica: hemoglobina y Rh -Administrar MIFEPRISTONA (dosis de 200 mg ) -Se dan instrucciones para volver en 2 días. -Entre 1-6% se produce la expulsión de los productos de la concepción. SEG

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PRESIDENTE CONSTITUCIONAL DEL ESTADO PLURINACIONAL DE BOLIVIA Que el Parágrafo II del Artículo 14 de la Constitución Política del Estado, establece que el Estado prohíbe y sanciona toda forma de discriminación fundada en razón de sexo, color, edad, orientación sexual, identidad de género, origen, cultura, nacionalidad, ciudadanía, idioma, credo religioso, ideología, filiación pol

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