IngentaConnect Post-dexamethasone cortisol correlateswith severity of depression.
during carbamazepine treatment in women Authors: Osuch, Elizabeth A.1; Cora-Locatelli,
Gabriela2; Frye, Mark A.3; Huggins, Teresa2; Kimbrell,
Timothy A.4; Ketter, Terence A.5; Callahan, Ann M.2; Post,
Robert M.2
Source: Acta Psychiatrica Scandinavica, Volume 104, Number
5, November 2001 , pp. 397-401(5)
Publisher: Blackwell Publishing
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Objective: Previous studies show a state-dependent
relationship between depression and post-dexamethasone
suppression test (DST) cortisol level, as well as differences in

Method: In this study, 74 research in-patients with affective
disorders were given the DST on placebo and in a subgroup
following treatment with carbamazepine. Depression was evaluated twice daily with the Bunney-Hamburg (BH) rating scale. Data were examined for the total subject population, by gender and by menopausal status in women.
Results: A robust positive correlation was observed between
depression severity and post-DST cortisol in pre- and
postmenopausal females, but not in males. This relationship persisted in women when restudied on a stable dose of;jse.
IngentaConnect Post-dexamethasone cortisol correlateswith severity of depression.

Conclusion: The pathophysiological implications of this
selective positive relationship between severity of depression
and post-DST cortisol in women, but not men, should be
Keywords: dexamethasone; cortisol; depression; gender;
menopause; carbamazepine
Document Type: Research article
Affiliations: 1: Uniformed Services University of the Health
Sciences, Bethesda, MD, 2: Biological Psychiatry Branch,
National Institute of Mental Health (NIMH), National Institutes
of Health (NIH), Bethesda, MD, 3: UCLA School of Medicine,
Los Angeles, CA, 4: North Little Rock VA Medical Center,
North Little Rock, Arkansas and 5: Stanford University School
of Medicine, Stanford, CA, USA
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