J. Chem. Inf. Comput. Sci. 2000, 40, 773-777 Estimation of Aqueous Solubility for a Diverse Set of Organic Compounds Based on Molecular Topology Division of Pharmaceutical Chemistry, Department of Pharmacy, POB 56, FIN-00014,An accurate and generally applicable method for estimating aqueous solubilities for a diverse set of 1297organic compounds based on multilinear regression and ar
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Warfarin dosage and inr chartWarfarin Dosage and INR Chart
Indication for Warfarin:_____________________________________
INR 2-3: Prophylaxis of venous thrombosis (high risk surgery), treatment of venous thrombosis or PE, Prevention of systemic embolism (Tissue heart valves, AMI, Valvular heart disease,
INR 2.5-3.5: Mechanical prosthetic valves (high risk), bileaflet mechanical valve in aortic position
Age:_________ Height:___________ Weight: _________
Recommendations for Warfarin Titration and Monitoring:
Initiate warfarin with the dose that is expected to be required for maintenance therapy (7.5 mg if < 50 years old, 5 mg if > 50 years). Loading doses are not recommended. If larger doses are used, 10 mg, PTTs should be therapeutic if receiving heparin or the patient should be receiving enoxaparin. Consider the patient’s age, weight, nutritional status, and concurrent disease states and medications when choosing a maintenance dose of warfarin. The following factors are associated with increased warfarin sensitivity: age > 65 years, female gender, low body weight, poor nutritional status, low vitamin K intake, and concurrent disease states (liver disease, hypermetabolic states, hyperthyroidism). Draw daily INR’s for the first 5-7 days of therapy and then two-three times a week during initiation. If rapid anticoagulation is required enoxaparin or heparin should be overlapped with warfarin for at least the first four days. Discontinue enoxaparin/heparin when the INR is therapeutic on two consecutive measurements. Dosage adjustments of warfarin are best made reflecting the 36-48 hour delay in peak response of the INR to a previous dose of warfarin. Dosage adjustments are not recommended any more frequent than every 2-3 days. Warfarin displays non-linear kinetics, small dosage adjustments (1-2.5 mg) are recommended. The patient's dose response curve for several days should be reviewed.
On Coumadin at Home: Yes / No / Unknown Home Dose and schedule________________
Date of last dose___________________
Warfarin Dose (mg)
Vitamin K Dose (mg) & Route
Please complete this
Interacting Medications of major clinical significance*, platelet aggregation inhibitors, and anticoagulants
ons of maj
Please complete this section. Only
*Commonly used interacting medications are listed on the reverse side. Management of Nontherapeutic INRs: Chest Recommendations 2001
Lower the dose or omit a dose and resume therapy with lower dose when INR therapeutic. Omit next one or two doses, monitor the INR more frequently, and resume therapy with lower dose when INR therapeutic. If risk of bleeding, omit the next warfarin dose and give 1-2.5 mg vitamin K orally. Give 3-5 mg vitamin K orally; expect reduction of INR in 24-48 h; monitor INR more frequently; and repeat vitamin K if necessary. Give 10 mg vitamin K by slow IV infusion, supplemented with fresh frozen plasma or prothrombin complex concentrate depending on the urgency of the situation. Vitamin K can be repeated every 12 h. Give prothrombin complex concentrate supplemented with 10 mg vitamin K by slow IV infusion. Repeat as necessary. Keep at the front of physician orders section of the chart
Commonly Used Medications with Major Interactions with Warfarin*
Action to be taken
Only interactions of major clinical significance are to be recorded on the front of this form.
The Warfarin Dosing and INR Chart will be placed at the front of the physician orders section of the chart and will be moved to the front of the progress notes each day. A Warfarin-Monitoring sticker will be placed on the front of the chart. Nursing staff will place the form on the chart and fill out all portions of the Warfarin Dosing and INR Chart with the exception of drug interactions. A. The night shift nurse will record the INR if it is available. B. The nurse administering the warfarin will record the dose administered and INR if it is not already recorded. The cardiopulmonary pharmacist or designee will review all patients daily. A. Ensure a Warfarin Dosing and INR Chart is in the physician orders section of the chart. B. Ensure a sticker is on front of the chart. C. Ensure all elements of the form are complete. D. Ensure that the patient has a routine INR order. E. Review the patient's profile for drug interactions of major clinical significance, which will be noted on the monitoring form. F. Review the chart, INR and warfarin dosing history for trends, and appropriateness of the current warfarin order. The physician will be G. Fill in the indication, if available from the patient's medical record. The Adverse Drug Event Form will be completed for all patients requiring vitamin K or experiencing a negative outcome. Information from this form will be placed in a database, which will be used to track outcomes and identify opportunities for improvements. All patients not on a fixed daily dose of coumadin will have an order entered for warfarin daily dose (PCO code=WDD). This will help to ensure physicians will order coumadin daily and help in report generation for patients currently on warfarin. A Pyxis report of all patients with warfarin daily orders will be generated each day for the pharmacists use.
La Pedagogía del Texto y la enseñanza/aprendizaje de las matemáticas: un abordaje interdisciplinario Corporación Educativa CLEBA – Medellín 1. Contextualización Las matemáticas en la educación de base de jóvenes y adultos no han ocupado el lugar que les corresponde, especialmente en los países del Tercer Mundo. A pesar de algunas referencias sobre el asunto, como es