This Issue:
◆ Ativan, Benadryl, and Haldol (ABH) Gel and Ativan, Benadryl, Haldol, and Metoclopramide (ABHM) Gel in the Treatment of Nausea
◆ DermaZinc-Plus with Clobetasol for the Treatment of Psoriasis ◆ Intranasal Fentanyl Citrate and Cancer-Related Breakthrough Pain ◆ Compounding Law Rescinded March 2001
was still experiencing some nausea. I sug-
a 10-mg/mL concentration to the gel; thedose (a topical application of 1 mL every
4 to 6 hours) was to remain unchanged.
After 2 doses of treatment with this for-
mulation, the patient’s nausea was relieved.
She continued this protocol and experi-enced relief from nausea until her death in
John Herr, RPh John Farkus, MD
cally applied medication to be very effec-
Town and Country Pharmacy,
tive in decreasing the anxiety and nauseaproduced by some diseases during the end-
Ridgewood, New Jersey
1. Carling MA. Hospice and the role of the
palliative therapy for a 78-year-old woman
compounding pharmacist. IJPC. 2000;4:247-
who was dying of cancer of the stomach.
2. Allen LV. Hospice care and the pharmacist.
sea than from pain. Her physician had pre-
scribed antiemetic trimethobenzamidesuppositories (Tigan) 200 mg to be usedevery 6 to 8 hours as needed, but this medi-
hospice care interdisciplinary team for thepurposes of assessing and determining
David Holloway, RPh
treatments for terminally ill patients. At
Trail Creek Pharmacy, Euless Texas
our meeting on March 15, 2000, I sug-gested that a topical Ativan, Benadryl, and
became the patient of a physician located
had been added be prescribed to alleviate
this patient’s nausea, and her physician
tient had been diagnosed as having psoria-
sis, for which he had been treated by sev-
mixed in a Pluronic lecithin organogel in
eral physicians. When the patient received
his diagnosis, his family history indicated
that no other relatives had psoriasis, but
SAMPLE (to enhance absorption)
the patient’s elbow as a scaling sore that
The patient was instructed to apply 1 mL
did not heal, and in 1997 the lesions ap-
of this gel to her wrist every 4 to 6 hours
At the time of our interdisciplinary team
The patient’s primary complaint was that
cause of that pain in the remaining subjects.
the subjects had been receiving oral mor-
The average number of daily pain episodes
his scalp. His physician prescribed a zinc
was five, and 50% of the subjects rated the
pyrithione formula with clobetasol propi-
eight patients (66.6%), the pain lasted 30
mL spray bottle. The medication was to be
may occur several times per day for short
applied twice daily. DermaZinc is an over-
At the time of the study, all subjects had
periods, the effects of short-acting mor-
been receiving morphine in various proto-
cols (listed in Table 2 of the article) as
continue beyond the duration of pain; re-
peated dosing can result in adverse effects.
twice per day) for breakthrough pain. Re-
many disadvantages for the patient: Their
morphine was rated as “good” by four pa-
administration is invasive and uncomfort-
tients (33%), “fair” by five (42%), and
mula when clobetasol is added. Our patient,
like many others with psoriasis, required
At the initiation of the study, each pa-
multiple therapies in order to restore his
tient began a protocol of receiving 20 µg
toxic effect on local tissue, it can be used
of intranasally administered fentanyl cit-
as long-term therapy. It is delivered as a
In addition to treatment with the spray,
bottle with a 0.2-mL reservoir. Each spray
bottle delivered a 0.2-mL bolus dose with
other day, and the patient was to receive
to replace treatment with short-acting oral
the treatment of neuropathic pain and dur-
morphine, which had been used as the res-
ing painful treatment procedures. Because
minutes from a tanning bed 2 times a week.
INFC was well-tolerated and well-received
After 5 months of following this regimen,
breakthrough pain was completely relieved
the patient was doing well and his psoria-
that additional studies be conducted to de-
sis had completely resolved. When he used
with that dosage. If partial relief or no pain
termine the role of that therapy in the man-
relief resulted, each patient was given a
second bottle to provide sufficient drug to
the time of this writing, he is continuing
spray both nostrils. All patients required
Legal Update
were asked to use the INFC spray for five
and the ultraviolet light therapy and is do-
1. Fenrich J, Vidaurri V. Psoriasis. IJPC 2000;
challenged for its constitutionality during
3. Allen, LV. Environmental sensitivities. IJPC
taken before the trial were continued with-
government’s restrictions that prohibit
Literature Summary
sion of the trial, the subjects were asked
In Western States Medical Center v.Shalala, a case brought by a group of li-
was also asked to list the advantages and
censed pharmacies, the court found that the
disadvantages of taking medication to con-
An assessment of the safety, efficacy, and acceptability of SAMPLE
After treatment with INFC, eight patients
intranasal fentanyl citrate in the
(66%) demonstrated a reduction in the VAS
management of cancer-related
score. Four of those patients noted a re-
In its opinion, the Court stated that the
breakthrough pain: A pilot study.
duction in pain 5 minutes after having used
FDA failed to prove that they have a sub-
Source: Zeppetella G. J Pain
INFC, and seven patients noticed pain re-
stantial interest in preventing widespreadcompounding. They stated that FDA fails
Symptom Manage 2000;20:253-258.
lief after 10 minutes. Those eight patients
to support the opinion that increased dis-
rated the efficacy of INFC as “good” or
“very good.” Nine patients (75%) indi-
ous because of the health risks associated
ing treatment for cancer. This type of pain,
cated that INFC was as effective as or bet-
with large numbers of patients taking such
which afflicts patients despite the use of
drugs. The decision states that most evi-
the effectiveness of INFC as “moderate”
dence runs to the contrary noting that com-
curs frequently and is brief in duration and
or “bad.” According to the author, patients
pounding is legal under state law and that
doses of morphine showed a decline in the
above, an analgesic with the following at-
tributes would be of benefit in treating pa-
those who had been receiving a daily mor-
rapid absorption, an “individual and epi-
not. During the study, two patients required
sodic titration,” a rapid onset of action, and
have laws specifically setting forth param-
a short-to-moderate duration. Intranasally
morphine in spite of taking INFC, and two
eters for pharmacy practice. In addition,
the drug was used repeatedly. No systemic
practice and the United States Pharma-copeia has created an entire chapter on
experiencing one type of nociceptive can-
were noted. At the conclusion of the study,
Although the implication of the court’s
continue treatment with INFC, and the re-
decision is unclear from regulatory stand-
maining subjects were dissatisfied with the
point, the practice of compounding as nec-
those patients (75%), the site of the break-
effectiveness of the preparation rather than
RxTriad-Literature watch of the International Journal of Pharmaceutical Compounding. 2001 International Journal of Pharmaceutical Compounding. All rights reserved.
Report from the HIV Services Network (HSN)/Irish Civil Society representative on the Irish delegation attending the Mid-term Review of the United Nations Declaration of Commitment on HIV/AIDS 31st May to 2nd June, United Nations, New York The Political Declaration and speeches summarised and/or referred to in this paper may be viewed in full on www.un.org/ga/aidsmeeting2006
Die Geburten meiner zwei Töchter – einmal ohne und einmal mit Traude. Kein Vergleich! BEL und Sophie Licht! Die Schwangerschaften Ich habe zwei gesunde Kinder (Sophie-Therese 2003, Amelie-Louise 2006) zur Welt gebracht und dennoch lässt sich dieses Kapitel ganz kurz halten: ich bin/war sehr gerne schwanger! Ich konnte es jedes Mal unheimlich genießen schwanger zu sein.