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Isni.org.il

Fellowship program in Neuroimmunology
The major goal of this fellowship program is to produce specialists with the knowledge and tools to diagnose, treat and prevent immune-mediated The fellowship will provide board certified neurologists to train for 6-12 months in the clinical or basic science research skills and management of patients with disorders of the nervous system due to dysregulation of the immune The fellow will have the opportunity to participate in specialty clinics that include the Multiple Sclerosis clinic, the Neuromuscular clinic and the Neuro- oncological clinic which deals with paraneoplastic syndromes. Besides, they will rotate on an inpatient consult service geared towards the care of patients with the above disorders. They will also have the opportunity to participate and become familiar with all the laboratory immunological tests used for the diagnosis and follow up of patients with neuroimmunological diseases, including CSF tests for oligocolonal (and other) antibodies, serum antibodies against neural antigens (paraneoplastic antigens), antibodies targeting the neuromuscular junction, AQP4 antibodies testing, FACS analysis of the lymphocyte subpopulations, techniques for the detection of cytokines and chemokines (expression and secretion), HLA and genetic tests. The research program will include didactic courses in the field of Neuroimmunology. The fellows will become familiar with the use and indications and practical issues of the old and novel immunosuppressive and immunomodulatory treatments for MS and neuroimmunological diseases (including cytotoxic therapies, interferons, glatiramer acetate, cyclophosphamide, azathioprine, mitoxanthrone, methotrexate, natalizumab, fingolinod, alemtuzumab, mabthera, laquinimod, BG12, etc) and will have the opportunity to participate in ongoing clinical trials, and in the design and performance of novel preclinical and clinical studies. They will have the ability to choose from a wide variety of basic science projects in the laboratories of the faculty within the division. These include state of the art techniques in proteomics, lipidomics and genomics in addition to core neuroscience and immunology and usage of experimental animal models of neuroimmunological Clinical training:
Fellows will receive intensive clinical training in the following areas:
 
 1) Differential diagnosis of multiple sclerosis (MS) and related disorders 2) Neurological presentations and management of systemic autoimmune, connective tissue diseases and CNS and PNS vasculitis. 3) Diagnosis and management of peripheral nerve and neuromuscular 4) Prophylactic agents for relapsing-remitting MS 
 5) Treatment of progressive or aggressive MS and demyelinating diseases, including the use of chemotherapeutic agents and monoclonal antibodies
 6) Interpretation of MRI and other imaging techniques of relevance to MS
 and other similar diseases affecting the CNS 7) Symptomatic treatments for management of pain, spasticity, fatigue, bowel- 8) Rehabilitation of chronic neuroloimmunological diseases
 Program Overview
a. Didactic courses (during the whole period of the fellowship):
 
  Clinical Neuroimmunology  Overview of cytotoxic, immunosuppressive and immunomodulatory  Laboratory of Neuroimmunology and neuroimmunological techniques  Neuroradiology (in relation to neuroimmunological diseases) b. Basic clinical activities (during the whole period of the fellowship):
 
 Fellows will attend one of the MS/Neuroimmunology clinics two days each week and will become familiar with the diagnosis and management of:  Multiple Sclerosis  Neuromuscular diseases (myasthenia gravis, AIDP, CIDP and related  Neurological complications of connective tissue diseases and  Lumbar Puncture and Cell Infusion techniques  2-3 months rotation in the Neuroimmunology Laboratory d. Additional elective rotations (total of 2 months):  Neuro-ophthalmology  Neuropathology  Neuroradiology  Neurovirology  Neuro-Urology  Neuro-rehabilitation Suggested syllabus:
by Patricia K. Coyle and Syed Rizvi (Sep 1, 7. CONTINUUM OF THE American academy of Neurology:
8. CONTINUUM OF THE American academy of Neurology: Paraneoplastic
9. CONTINUUM OF THE American academy of Neurology: Peripheral
10. CONTINUUM OF THE American academy of Neurology: Infectious
11. CONTINUUM OF THE American academy of Neurology: Multiple
12. CONTINUUM OF THE American academy of Neurology: Neurologic
Complications of Systemic Disease - February 2011

Source: http://www.isni.org.il/FellowshipinNeuroimmunologyupdatedcopy.pdf

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