CONVOCATORIA PÚBLICA No. _____ DEL ________ DE 2010 INVITACIÓN PÚBLICA SUBASTA INVERSA PARA CONTRATO INFERIOR AL 10% DE LA MENOR CONFORMIDAD CON LO ESTABLECIDO EN EL DECRETO 3576 DE 2009, INFORMA A LOS INTERESADOS QUE APARTIR DEL VEINTIUNO (21) DE ABRIL Y HASTA EL NUEVE (23) DEL MISMO MES DE 2010, ESTÁ ABIERTA LA CONVOCATORIA PÚBLICA A PRESENTAR PROPUESTAS PARA LA ESCOGENCIA MEDI
The following diseases are transmitted by sexual contact:gonorrhoea, chlamydia infections, chancroid, genital herpes,trichomoniasis, syphilis, chlamydia lymphogranuloma, granuloma inguinale, genital warts, pubic lice, scabies, viral hepatitis B and human immunodeficiency virus,.
Sexually transmitted diseases in sailors are generally acquired through unprotected casual and promiscuous sexual contacts, often with prostitutes.
The most common symptoms of sexually transmitted diseases include discharge, redness and swelling of the genitalia, genital ulcers, lymph node enlargement, warts,and the presence of lice or mites on or in the skin. In some sexually transmitted diseases a single organ is affected. while in others the infection spreads. throughout the body.
Clinical and laboratory facilities are necessary for accurate diagnosis of sexually transmitted diseases. Since suchfacilities are not likely to be available on board ship, the medical attendant can make only a presumptive diagnosis, based on rough clinical criteria. If the ship is more than oneday from port, the medical attendant should start antibiotic treatment immediately when a sailor is thought to be suffering from a sexually transmitted disease. The subjective and objective symptoms, treatment, and response to treatment should be carefully recorded.
On arrival in port, the patient should be referred as soon as possible to a specialist who can perform the appropriate diagnostic tests and, if necessary, give additional treatment.
Sexually transmitted diseases
If possible, all sexual contacts of the patient should be traced and told to seek medical advice.
In case of any doubt concerning diagnosis or treatment, RADIO MEDICAL ADVICE should be obtained.
Urethritis and urethral discharge
Urethritis is characterised by a discharge from the orifice ofthe urethra, a burning sensation and pain on urination, or an itch at the end of the urethra. Urethritis may be caused by the gonococcus (gonorrhoea) or chlamydia.
Gonococcal urethritis tends to produce more severe symptoms than non-gonococcal urethritis. The incubationtime of gonococcal urethritis can range from I to 14 days, but is usually 2–5 days. The discharge is generally abundant,yellow, creamy and purulent.
Non-gonococcal urethritis is generally caused by chlamydia, but in some cases, no causative organism can befound. The discharge in non-gonococcal urethritis is usuallyscanty, watery, mucoid or serous.
In men, a careful distinction must be made between urethritis and balanitis or posthitis, in which there aresecretions from the glans penis and the prepuce (foreskin).
Wearing disposable gloves, carefully retract the prepuce todetermine the origin of the discharge or secretions.
In women, the same organisms that cause urethritis can cause infection of the cervix of the uterus and the urethra. Inmore than 60% of women with such infections, there are novisible symptoms. In the remaining cases, the principal sign isan increase in the vaginal discharge (see also Vaginaldischarge).
Rectal infectionThe organisms that cause urethritis can also infect the rectum. The main symptoms are adischarge of pus, sometimes mixed with blood, and itching around the anus.
ConjunctivitisMale and female patients with urethritis may also develop an infection of the conjunctivae ofthe eye.
It is not generally possible to make a definitive diagnosis of the cause of urethritis withoutlaboratory facilities. Treatment must therefore be effective for both gonococcal and non-gonococcal infections, and must take account of the facts that the patient may be infected withmore than one type of organism, and that some strains of gonococcus are resistant to penicillin.
Patients should be given Ciprofloxacin 250 mg as a single and Doxycycline, one 100 mg capsule ortablet twice daily for 7 days.
This treatment should be effective for all urethral and rectal infections. If the patient also has conjunctivitis, 1% tetracycline ointment should be applied to the eye 3 times daily for oneweek. About one week after completion of treatment, the patient should attend a specialistclinic to verify that he is no longer infected.
A swollen scrotum can be defined as an increase in volume of the scrotal sac, accompanied byoedema and redness. It is sometimes associated with pain (or a history of pain), urethraldischarge, and a burning sensation on urination (see Urethritis and urethral discharge). Theswelling of the scrotum is usually confined to one side.
Among ships’ crews most cases of swollen scrotum are caused by inflammation of the epididymis, produced by sexually transmitted organisms. Such a cause should be stronglysuspected in patients with urethral discharge or a recent history of it. The onset of epididymitisis often acute, but in some cases, it may develop over 24–48 hours. There may initially be an‘unusual sensation‘ in the scrotum, which is rapidly followed by pain and swelling. The pain is ofa dragging, aching nature.
This condition must be distinguished from testicular twisting (see testicular pain, Chapter 7).
In the latter case, the testis can become non-viable within 4–6 hours of onset of vascularobstruction. This condition occurs most frequently in children and is very rarely observed inadults over the age of 25. The presence of a history of urethritis would exclude the diagnosis. Incases of testicular twisting the testicle is often slightly retracted and elevation of the scrotumdoes not decrease the pain. This condition needs urgent referral. Other conditions that maylead to scrotal swelling include trauma (injury), inguinal hernia, mumps, and tumours.
Balanitis and posthitis
Balanitis is an inflammation of the glans of the penis, and posthitis is an inflammation of theprepuce. The two conditions may occur simultaneously (balanoposthitis). Lack of goodhygiene, in particular in uncircumcised males, is a predisposing factor, as is diabetes mellitus.
In balanitis and balanoposthitis, a mild to profuse superficial secretion may be present. This must be carefully distinguished from urethral discharge. Wearing disposable gloves, retract theprepuce in order to determine the origin of the secretion.
Other signs include itching and irritation, causing considerable discomfort. Sometimes, the penis is swollen and retraction of the prepuce may be painful. Redness, erosion (superficialdefects), desquamation of the skin of the prepuce, and secretions of varying aspects andconsistency can be observed.
The glans of the penis and the prepuce should be washed thoroughly with warm waterantiseptic three times daily. Fluconazole 150 mg as a single dose should be given. If there is noimprovement within one week, the patient should be referred to a specialist ashore.
Chapter 6.1 SEXUALLY TRANSMITTED DISEASES Genital ulcers
Genital ulcers are a common reason for consultation, particularly in tropical countries. If nottreated appropriately serious complications may arise from some of these conditions. Ulcersmay be present in a variety of sexually transmitted diseases, including chancroid, genitalherpes, syphilis, chlamydial lymphogranuloma, and granuloma inguinale.
The prevalence of these diseases varies according to geographical area. In Africa and South- East Asia, for instance, chancroid is the most common cause of genital ulcers, whereas in Europeand the USA, herpes genitalis is most common. Chlamydial lymphogranuloma and granulomainguinale are much less common, and occur mainly in specific areas of the tropics. Chlamydiallymphogranuloma is endemic in West Africa and South-East Asia, while granuloma inguinale isprevalent in east Africa, India, certain parts of Indonesia, Papua New Guinea, and Surinam. Eachof these diseases is described in more detail in the following pages.
Patients with one of these diseases usually complain of one or more sores on the genitals or the adjacent area. If the ulcer is located on the glans penis or on the inside of the prepuce,uncircumcised males may complain of penile discharge or of inability to retract the prepuce.
In females, ulcers may be situated on the vulva, in which case the patient may complain of aburning sensation on urination.
Disposable gloves should be worn when examining the ulcers. The medical attendant should note the number and the characteristics of the lesions and the presence of lymph nodeswellings in the groin. Painless, indurated lesions can generally be attributed to syphilis;painful sores that bleed easily are attributable to chancroid; vesicular lesions that developinto superficial erosions or small ulcerations probably indicate herpes infection. Doubleinfections are not uncommon, however, the clinical symptoms are often not sufficientlydiscriminatory to enable a definite diagnosis to be made without the help of laboratory tests.
Knowledge of the relative importance of each disease in the area is crucial for a specifictherapeutic approach. The recommended regimen is therefore aimed at curing the mostfrequently encountered diseases, chancroid and syphilis.
Give simultaneously: 2.5 million units of benzylpenicillin, in one dose, intramuscularly and
ciprofloxacin 250 mg orally. If the patient is allergic to penicillin, give Doxycycline 100 mg, by
mouth, 2 times a day for at least 2 weeks.
When patients with syphilis are treated with penicillin, the so-called Jarisch- Herxheimer reaction may occur (see Syphilis). Bed rest should be advised for patientssuffering from very painful genital ulcerations and lymph node swelling, and for thosefeeling severely ill.
As soon as treatment has started, patients should no longer be regarded as infectious and no special hygienic measures need to be applied. On arrival at the next port patientsshould be referred to a specialist together with all relevant information concerning theirmedical history.
Chancroid, almost always acquired during sexual intercourse, is caused by a bacterium. The
incubation period (the time following the infecting contact to the initial appearance of
symptoms) is short, usually averaging 3–5 days. The lesions are usually only seen in men; in
women, clinical lesions are rare, but ulcers may be located in the vagina. The first lesion
usually appears as a small inflamed bump, soon forming a blister or pustule, which breaks
down within 2–3 days to become a very painful ulcer.
The classic chancroid ulcer (primary lesion) is superficial and shallow, ranging from a few millimetres to 2 cm in diameter. The edge usually appears ragged and is surrounded by a redzone. The base of the ulcer is covered by a necrotic exudate and bleeds easily. In contrast tothe syphilitic chancre, the lesion is soft, and extremely painful and tender.
In males the most frequent sites of infection are the inner and outer side of the prepuce and the groove separating the head from the shaft of the penis.
About l~2 weeks after the appearance of the primary lesion, the glands in the groin become enlarged, painful, and tender (buboes) (see Lymph node swelling, and Lymphatic inflammation, Chapter 7). At first, the swellings appear hard and matted together, but theysoon become painful and red. Some time later, the lymph nodes may enlarge, becomefluctuant, and discharge pus.
Give the patient Doxycycline 100 mg 2 times daily for 7 days. If the buboes persist or become
fluctuant, RADIO MEDICAL ADVICE should be sought.
Genital herpes is caused by a virus; the disease can follow an asymptomatic course, the virus
being harboured within the nerves to the skin without producing symptoms. Usually,
however, genital herpes in men appears as a number of small vesicles on the penis, scrotum,
thighs, or buttocks. The fluid-filled blisters are usually painful, but sometimes produce only a
tingling sensation. Within a day or two the blisters break, leaving tiny open sores which take
1–3 weeks to heal. Lymph glands near the site of infection may react by becoming swollen
In most cases, a clinical diagnosis can be made on the basis of the appearance of the lesions, in particular at the blister stage. At specialised clinics, laboratory tests may be used to confirmthe diagnosis.
After the sores are healed, the virus remains dormant in the body. Weeks or months later, there may be recurrence of the active infection. These recurrent attacks tend to become lessfrequent with time and to be less severe than the initial attack, and the lesions tend to healmore quickly.
A definite cure for genital herpes is not yet available. Lesions should be kept clean by washingthe affected sites with soap and water, followed by careful drying. Analgesics may be given toreduce discomfort.
If you are in any doubt about whether the diagnosis of genital herpes is correct, the patient should be managed as described under Genital ulcers.
Syphilis is caused by a spirochaete which enters the body through the mucous membranes ofthe genitals, rectum, or mouth, or through small cuts or abrasions in ordinary skin.
The clinical course of syphilis is usually divided into three stages. The lesions of the primary and secondary stages are usually painless and cause little disability. They may heal withouttreatment, and the disease can lie dormant in the body for several years. In the late stagessyphilis can cause serious damage to the brain, spinal cord, heart, and other organs.
The first stage, primary syphilis, is characterised by the presence of a sore (or chancre) at the point where the spirochaetes enter the body. There is a delay of 10–90 days (average 3weeks) after contact before the onset of any visible sign of infection. Following theappearance of the initial chancre, there can be an additional delay of a few weeks beforethe blood test for syphilis will become positive. The typical chancre occurs in the grooveseparating the head from the shaft of the penis. However, a chancre may occur anywhereon the body where there has been contact with an infected lesion. Such lesions are usuallysingle, but there may be more than one. The primary chancres are often smooth and clean-looking on the surface. Sometimes the lesion ulcerates and leaves a reddish sore with thebase of the ulcer covered by a yellow or greyish exudate. Unless there is also infection withother bacteria or with herpes virus, the ulcer will be painless. The lesion has a characteristicfirmness (like cartilage) when felt between the thumb and forefinger (gloves must beworn) Often there will be one or more rubbery, hard, painless, enlarged lymph nodes in one or both groins, or in other regions if the sore is not on the genitals. In the presence of asecondary infection, the nodes may be tender. Usually these lesions will heal spontaneouslywithin 6 weeks. At the chancre stage, the patient is highly contagious Chapter 6.1 SEXUALLY TRANSMITTED DISEASES The secondary stage of syphilis usually develops about 6–8 weeks after the appearance of the primary chancre. In fact, the primary syphilitic chancre may still be present at thetime of onset of the secondary stage. However, the secondary stage may be the firstmanifestation, occurring some 10–14 weeks after the infected contact. The most consistentfeature of secondary syphilis is a non-itching skin rash, which may be generalised in theform of small, flat or slightly elevated pink spots, which gradually darken to become darkred in colour. They may be particularly localised on the palms, soles, or genital areas. A lessfrequently encountered sign is patchy loss of scalp hair. Patients with secondary syphilismay complain of malaise (not feeling well), headache, sore throat, and a low-grade fever(38.5 C). The presence of these symptoms plus a generalised rash and/or a rash involving thepalms and the soles, which does not itch, and is associated with enlarged small lymph nodesin the neck, armpits and groins, should arouse suspicion of secondary syphilis. Other signsof the secondary stage may be the occurrence of moist sores, particularly in the genitalarea, or of flat, moist warts in the anogenital region. It should be noted that moist lesionsof secondary syphilis are teeming with spirochaetes and are thus highly infectious. In theuntreated patient the diagnosis is confirmed by microscopic examination of the lesions andby a blood test for syphilis.
The symptoms of the secondary stage will eventually disappear without treatment. The disease then enters the latent (hiding) phase, before reappearing as tertiary syphilis manyyears later.
Patients with suspected syphilis should be given 2.5 million units of benzylpenicillin in a singledose, administered intramuscularly. If the patient is allergic to penicillin, give either 100 mg ofDoxycycline by mouth, 2 times a day for 14 days or 500 mg of erythromycin by mouth, 4 times aday for 14 days. The patient should be referred to a specialist clinic at the next port of call.
Caution. When treated with antibiotics, about 50% of patients with primary or secondary
syphilis will develop the so-called Jarisch-Herxheimer reaction, which usually appears 6–12
hours after the injection. This reaction is characterised by fever, chills, joint pain, increased
swelling of the primary lesions, or increased prominence of the secondary rash. It is caused by
the sudden destruction of a great number of spirochaetes and should not give rise to alarm.
Analgesics may help to reduce the symptoms.
Chlamydial lymphogranuloma is a systemic disease of venereal origin. The incubation timeranges from 4 to 21 days. The primary lesion is usually an ulcer, a vesicle, a papule or a pustule,not more than 5–6 mm in size and often located on the groove on the head of the penis in themale patient. Commonly single, the lesion is painless, transient, and heals in a few days withoutscar formation. in most cases, the patient does not even notice this primary ulcerative lesion.
After the lesion has healed, the commonest symptom in heterosexual men is acute swelling ofthe lymph nodes in the groin, often on one side only. The swelling starts as a firm hard mass,which is not very painful, and usually involves several groups of lymph nodes. Within 1–2 weeks,the glandular mass (bubo) becomes attached to the skin and subcutaneous tissue and painfulfluctuation occurs, followed by formation of pus. Not all buboes become fluctuant, someevolve into firm masses. Perforation of a bubo may occur, whereupon pus of varying aspect andconsistency will be discharged. If not treated, chlamydial lymphogranuloma can produce severescarring in the urogenital and rectal regions.
Rest in bed is recommended for patients with chlamydial lymphogranuloma. An ice-bag may beapplied to the inguinal region for the first two or three days of treatment to help relieve localdiscomfort and tenderness.
The patient should be given 100 mg of Doxycycline by mouth, twice daily for at least 2 weeks or 500 mg of erythromycin by mouth, 4 times daily, for at least 2 weeks. Fluctuating buboes
require aspiration. If the bubo persists, RADIO MEDICAL ADVICE should be sought.
Granuloma inguinale is an infectious bacterial disease, with insidious onset. The sites usuallyaffected are the genitals, the groin, the upper legs next to the groin, and the perianal and oralregions. The incubation period ranges from 17 to 50 days.
The earliest cutaneous lesion may be a papule or a nodule, which ulcerates, producing a single, enlarging, beef-like, velvety ulcer, or a coalescence of several ulcers. The typical ulcer in thisdisease is a raised mass, looking more like a growth than an ulcer. It has a smooth, elevated edge,sharply demarcated from the surrounding skin. There is no lymph node swelling and the generalhealth of the patient is good. If not treated, the lesions may extend to adjacent areas of the body.
The diagnosis can usually be made on the basis of the typical clinical picture. At specialised clinics microscopic examination of crushed tissue smears is used to confirm the diagnosis in theuntreated patient.
The patient should be given Doxycycline 100 mg 2 times a day for at least 2 weeks. The patientshould be referred to a specialist clinic at the next port of call.
Lymph node swelling
Lymph node swelling is the enlargement of already existing lymph nodes. It is unusual forlymph node swelling to be the sole manifestation of a sexually transmitted disease. In mostcases, inguinal lymph gland swelling is accompanied by genital ulcers, infection of the lowerlimbs, or, in a minority of cases, severe urethritis. The swelling may be accompanied by pain andmay be on one or both sides. Pain and/or fluctuation can sometimes be evoked by palpation.
The lymph node swelling may be regional (for instance in the groin in the presence of genital ulcers, etc.) or may involve more than one region (for instance in the case of secondary syphilisor human immunodeficiency virus infection).
The prepuce of patients suffering from lymph node swelling should always be retracted during examination in order to detect genital ulcers or scars of genital ulcers.
The patient should be treated as described under Genital ulcers. If no improvement is noted
within one week, RADIO MEDICAL ADVICE should be obtained.
Sexually transmitted diseases in women often produce an increase in the amount, or a change inthe colour or odour, of vaginal secretions. Vaginal discharge is probably the most commongynaecological complaint. It may be accompanied by itching, genital swelling, a burningsensation on urination, and lower abdominal or back pain.
Various infections can produce such symptoms.
Trichomoniasis is a common disease, particularly in tropical areas. It is characterised by a sometimes foul-smelling, yellow, or green foamy discharge.
Vaginal candidiasis is also a very common disease throughout the world. It is characterised by a white, curd-like discharge, vulvar itching, and sometimes a red and swollen vulva and vagina.
Bacterial vaginosis is very common. In general, there is no itch. The typical discharge is a grey sometimes foamy, fishy-smelling paste.
Other infections, e.g., gonorrhoea, may produce a white or yellow, watery or purulent Infection with herpes virus usually produces painful lesions (redness, blisters, ulcers) on the It should be remembered that more than one infection may be present at a time.
In a situation without gynaecological examination facilities and in the absence of laboratoryequipment the following practical approach should be followed. First the patient should be Chapter 6.1 SEXUALLY TRANSMITTED DISEASES treated for trichomoniasis and/or bacterial vaginosis (treatment A). If the condition does notimprove, this treatment should be followed by an anti-gonococcal and anti-chlamydial treatmentregimen (treatment B). If the symptoms still persist, an anti-candidiasis treatment (treatment C)should follow, or the patient should be referred to a specialist at the next port of call.
Give metronidazole 2.0 g, by mouth, in a single dose.
Give Doxycycline 100 mg , by mouth, 2 times a day for 7 days.
Fluconazole 150 mg, by mouth as a single dose.
Pelvic Inflammatory disease – Salpingitis
Pelvic inflammatory disease is a general expression covering various pelvic infections in women,caused by micro-organisms, which generally ascend from the lower genital tract (vagina, cervix)and invade the mucosal surface of the uterus, the fallopian tubes, and the peritoneum.
Pelvic inflammatory disease, caused by sexually transmitted pathogens, is a major cause of infertility and chronic abdominal pain, and may result in ectopic pregnancy. A vigorousapproach to treatment is therefore justified.
The symptoms include mild to severe lower abdominal pain on one or both sides associated with fever and vaginal discharge (see Vaginal discharge).
The use of an intra-uterine (coil) device may be associated with the development of pelvic inflammatory disease. It should be noted that it is difficult to diagnose pelvic inflammatorydisease without appropriate gynaecological and laboratory investigations; moreover, it is difficultto differentiate this disease from other causes of acute abdominal pain, e.g., appendicitis.
In a case of suspected pelvic inflammatory disease, RADIO MEDICAL ADVICE should be
The treatment is Doxycycline, 100 mg twice daily for 14 days in combination with metronidazole, 1.0 g, by mouth, twice daily, for 14 days.
Caution. Patients should abstain from alcohol during treatment.
Genital warts are caused by a virus, and occur most frequently in young adults. In male patients,warts may be present on the penis, around the anus, and in the rectum. In females, the usualsites of infection are the vulva, the area surrounding the anus, and the vagina. Warts are soft,flesh-coloured, broad-based or pedunculated lesions of variable size. They may occur singly, orseveral may coalesce to form a large mass, often with a cauliflower-like appearance. Small wartscause little discomfort, but large genital or anal warts are embarrassing and uncomfortable tothe patient and are liable to ulcerate; secondary infection and bleeding may then occur.
Diagnosis is usually made on clinical grounds.
There is no appropriate treatment that can be given on board ship. The patient should bereferred to a specialised clinic at the next port of call.
Pubic lice are nearly always sexually transmitted. The infection has become endemic in manycountries, usually affecting young adults. The main symptom is moderate to severe itching.
leading to scratching, redness, irritation and inflammation. The lice may be observed as smallbrown spots in the groin and around the genitals and anus. The nits attached to the hairs maybe seen with the aid of a magnifying glass.
Lindane cream, 1%, should be applied to the affected areas (pubic area, groin, and perianalregion) at 8–hour intervals over a period of 24 hours. The patient should take a showerimmediately before each application. At the end of the 24–hour period, the patient shouldagain shower, and put on clean clothes.
Scabies, caused by a mite, is now recognised as a sexually transmitted disease in industrialisedcountries. The most common symptom is itching, particularly at night. The lesions are roughlysymmetrical.
The usual sites of infection are the finger webs, sides of the fingers, wrists, elbows, axillary folds, around the female breasts, around the umbilicus, the penis, the scrotum, buttocks andthe upper part of the back of the thighs.
With the naked eye, only papules, excoriations and crusts may be seen. Using a magnifying glass, it is possible to detect the burrows of the mites.
Diagnosis is usually made on the basis of the clinical picture. At specialised clinics microscopic examination of skin samples can be performed, to detect the female scabies mite and her eggs.
A thin layer of lindane cream, 1%, should be applied to the entire trunk and extremities and leftfor 8–12 hours. At the end of this period. the patient should take a shower or a bath, andchange his clothes and bed linen.
Human Immunodeficiency Virus (HIV)
HIV infection is an increasing cause of premature death in both the developed and developingworld. In the majority of cases spread is by sexual contact. HIV infects the white cells responsiblefor immunity to disease and as the infection develops so the patient’s immunity to infectiondecreases and they become increasingly vulnerable to life-threatening infections. There areeffective drugs which can slow down the progression of the disease very considerably. Thesedrugs are expensive and only available to a small minority of patients. The majority of HIVinfected patients in the developing world will not survive more than 5 years. HIV infection wasoriginally called AIDS (acquired immune deficiency syndrome) because of the characteristicpattern of infections which developed in the first patients observed. This term is now of limiteduse as the original description of the disease bares little resemblance to the disease as it nowexists outside the developed world. HIV is present in the majority of the body fluids of an infected person. Nearly all infections result from contact with semen, vaginal secretions, blood or blood products. HIV is nottransmitted through normal social contact, including kissing. All those with HIV infectionshould be regarded as infectious, whether or not they have symptoms of the disease.
Within a few weeks of infection the patient may experience a glandular fever like illness.
Often this goes unnoticed, but occasionally the patient may be seriously unwell. At this pointthe HIV antibody test becomes positive. Following this the patient may be perfectly well forseveral years before developing serious infections. The first signs of HIV disease depend uponthe exposure of the patient to infectious diseases. In poorer countries, where standards ofhousing and hygiene are low, patients will present, within 2 to 3 years, with diarrhoea, chestinfections including tuberculosis and septicaemia. The patients have often lost a lot of weightand complain of fevers and tiredness. In developed countries patient may go many years beforepresenting with pneumonia, unusual skin cancers, meningitis and malignant tumours.
Nearly all the infections that cause illness in patients with HIV can be treated with antibiotics. Itis only the diseases that occur late on in HIV infection that require more complicated andexpensive treatments. These diseases all require laboratory tests to make the diagnosis. Severaldrugs are effective at limiting the development of HIV and these have dramatically altered the Chapter 6.1 SEXUALLY TRANSMITTED DISEASES natural course of the disease which usual ended in death within 10 years. The use of these drugsrequires frequent monitoring of the HIV infection.
There is no vaccine available. Appropriate anti-viral therapy can prevent the spread of diseasefrom mother to baby. It can also reduce the chance of infection following a needlestick injury.
The most common way in which infection is spread is by sexual contact. Many prostitutes in thedeveloping countries of Asia and Africa are HIV positive. Unprotected sexual intercourse withone of these prostitutes carries a very considerable risk of HIV transmission. The risk oftransmission is greatly increased if either partner has another sexually transmitted disease,particularly genital ulcers. One way of reducing HIV transmission is to detect and treat sexuallytransmitted diseases. Barrier contraceptives and spermicides provide very considerableprotection to HIV infection, but are not foolproof.
Proctitis is an infection of the rectum, often caused by sexually transmitted pathogens. Insymptomatic infections, a discharge of pus from the anus, sometimes mixed with blood, can beobserved. Itching around the anus may be present.
In females, proctitis is usually due to a secondary infection with vaginal discharge containing gonococci (see Vaginal discharge and Rectal infection). In male homosexuals, proctitis is causedby anal sexual contact with an infected person.
Patients should be treated according to the regimens outlined for urethritis and urethral
discharge. If there is no response to treatment within one week, RADIO MEDICAL ADVICE
should be obtained.
Treatment centres at ports
Many ports have one or more specialist centres, where seafarers can obtain treatment forsexually transmitted diseases. Where they exist, these centres should be used in preference tothe services of a general practitioner, since they have ready access to the necessary laboratoryfacilities, and experience of dealing with a large number of cases of sexually transmitteddisease.
The clinic staff will advise on any further treatment and tests that may be necessary. A personal booklet is given to the seaman, in which is recorded the diagnosis (in code) and thetreatment given, and which he should take with him if he visits a clinic in another port.
Instructions for medical attendants
The medical attendant should wear disposable gloves when examining any infected site inpatients suspected of suffering from sexually transmitted disease. If the attendant accidentallytouches any genital ulcer or discharge, or any material contaminated with pus from ulcers ordischarge, he should immediately wash his hands thoroughly with soap and water.
If there is a sore on the penis or discharge from the urethra, a clean gauze dressing should be kept on the penis. This dressing should be changed frequently. In female patients sufferingfrom genital ulcers or vaginal discharge, gauze or sanitary pads should be used.
Contaminated materials should be discarded in plastic bags, so that they will not be touched Instructions for patients
The patient should avoid all sexual contact until a medical specialist confirms that he is freefrom infection. He should also make a special effort to practice good personal hygiene; forinstance, he should use only his own toilet articles (toothbrush, razor, towels, washcloth etc.)and his own clothes and linen.
During the examination and treatment, the opportunity should be taken to inform the patient about his condition, sexually transmitted diseases in general, and the precautions to betaken to minimise the risk of acquiring them (see below).
Prevention of sexually transmitted disease
Being outside their normal environment and often in circumstances that allow for promiscuity,sailors are at special risk of contracting sexually transmitted diseases.
Avoidance of casual and promiscuous sexual contacts is the best way of minimising the risk of infection. Failing this, a mechanical barrier, such as a condom, can give both heterosexual andhomosexual men and women a certain degree of protection against a number of sexuallytransmitted diseases. A supply of condoms should be available on board ship. The condom orrubber, is a thin elastic covering that forms a protective sheath over the penis. If properly used,it should prevent infection during intercourse, unless the point of contact with an infectedlesion is beyond the area covered by the condom The condom comes rolled before use. It mustbe placed over the penis before sexual contact. The tip of the condom should be held to form apocket to receive the ejaculate and the rest of the condom unrolled to cover the entire penis. Assoon as the male has had an orgasm, the penis should be withdrawn from the vagina before itsoftens, because loosening of the condom may expose the penis to infection. The condom isremoved by grasping the open end with the fingers and pulling it down quickly so that it comesoff inside out. The condom should be discarded without further handling in case it containsinfectious material.
In women, the use of a diaphragm in combination with a spermicide cream offers some protection against the acquisition of some sexually transmitted diseases; however, condomsoffer better protection. In risk situations, both partners should urinate at once after possibleexposure. Each partner should subsequently wash his or her genitals and other possibleinfected areas.
A. Ersin ACAR 2011 Spring Semester Course Content: A) Modification of functional groups 1. Reduction 1. Heterogeneous catalysis 2. Homogeneous catalysis 3. Hydrogenation of C=C by diimide 4. Asymetric hydrogenation of acids (esters)-acylaminoacrylics 1.2. Hydrogenolysis of C-O, C-S, C-X, N-O, O-O bonds 1. H2/Pd (Pt, Ni) 2. Hydrogenolysis of C-Het at α position of C=O 1. Re