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Scientific publications 2007.doc

Prof. Matías Llabrés
Facultad de Farmacia
Universidad de La Laguna
38200 La Laguna, Tenerife
Spain

Scientific publications
Updated: April, 2007

MANOVA of statistical moments in biopharmaceuticals studies: a numerical example with three equally
doses of amoxicillin. Vila, J. L., Matínez-Pacheco, R., Jiménez, J., Llabrés, M. Journal of Pharmacokinetics
and Biopharmaceutics
8 (1980) 411 - 420
Quantification of the effect of excipients in bioavailability by means of response surface I: Amoxicillin in fat
matrix. Llabrés, M., Vila, J. L., Martínez-Pacheco, R. Journal of Pharmaceutical Sciences 71 (1982) 924 -
927
Quantification of the excipients in bioavailability by means of response surfaces II: Amoxicillin in fat - silica
matrix. Llabrés, M., Vila, J. L., Martínez-Pacheco, R. Journal of Pharmaceutical Sciences 71 (1982) 927 -
930
Quantification of the effect of excipients in bioavailabilty by means of reponse surfaces III: in vivo - in vitro
correlations. Llabrés, M., Vila, J. L., Martínez-Pacheco, R. Journal of Pharmaceutical Sciences 71 (1982)
930 - 932
La biodisponibilité: Etude critique et perspectives futures. Llabrés, M., Martínez-Pacheco, R., Vila, J. L.
Labo Pharma - Problème et Techniques 30 (1982) 155 - 161
Application du MANOVA des moments statistiques dans une étude de la biodisponibilité de trois
formulations de paracetamol. Concheiro, A., Vila, J. L., Llabrés, M. Pharmaceutica Acta Helvetica 59
(1984) 109 - 111
Limitations of the MANOVA of the statistical moments in bioequivalence trials of drug with slow
elimination rate: a study with spironolactone. Concheiro, A., Llabrés, M., Martínez-Pacheco, R., Vila, J. L.
Journal of Biopharmaceutics and Drug Disposition 7 (1986) 253 - 264
The statistical interpretation of accelerated degradation studies. Munguía, O., Parrilla, M. J., Llabrés, M.
Journal of Parenteral Sciences & Technology 40 (1986) 100 - 103
Dissolution rate and bioavailability of spironolactone tablets: effect of various technological factors.
Concheiro, A., Llabrés, M., Vila, J. L., Martínez-Pacheco, R., Blanco, J. Drug Development & Industrial
Pharmacy
13 (1987) 2301 - 2314
Statistical comparison of the dissolution curves of controlled - release solid dosage forms. Fariña, J., Llabrés,
M. Drug Development & Industrial Pharmacy 13 (1987) 1107 - 1118
Sustained release pharmaceutical oral dosage forms. Review of patented manufacturing process registeres in
the US Patent Office. Fariña, J., Llabrés, M. Sciene et Techniques Pharmaceutiques - Pharma 3 (1987) 505
- 509
Theoretical model for the interpretation of in situ absorption studies. Fariña, J., Evora, C. M., Espino, C.,
Llabrés, m. International Journal of Pharmaceutics 45 (1988) 123 - 128
Bioequivalence assessment of two comercial preparations of norfloxacine. Fariña, J., Evora. C. M.,
Hernández, C. M., Llabrés, M. Sciene et Techniques Pharmaceutiques - Pharma 5 (1989) 164 - 167
Gastro - intestinal bioavailability assessment of commercially prepared sustained - release lithium tablets
using a deconvolution technique. Llabrés, M., Fariña, J. Drug Development & Industrial Pharmacy 15
(1989) 1847 - 1841
Relationship between release and gastrointestinal absorption of theophilline. Sánchez, E., Evora, C. M.,
Llabrés, M. Acta Pharmaceutica Technologica 36 (1990) 7 - 10
A new approach to pharmacokinetic parameter estimation during haemodialysis. Cefuroxime. Sánchez, E.,
Evora, C. M., Torres, A., Llabrés, M. Journal of Biopharmaceutics and Drug Disposition 11 (1990) 107 -
120
Multivariate analysis of variance of dissolution data in the development of oral sustained release
formulations. Llabrés, M., Evora, C. M., Sánchez, E. Drug Development & Industrial Pharmacy 16 (1990)
2145 - 2152
Discrepancy between pharmacopoeial dissolution tests and bioavailability of paracetamol tablets. Evora. C.
M., Sánchez, E., Llabrés, M. Il Farmaco ed. pr. 65 (1990) 569 - 576
Design and evaluation of sustained - release tablets of lithium in a fat matrix and its bioavailability in
humans. Llabrés, M., Fariña, J. B. Journal of Pharmaceutical Sciences 80 (1991) 1012 - 1016
Effect of humidity and packaging on the log - therm aging of commercial sustained - release theophilline
tablets. Sánchez, E., Evora, C. M., Llabrés, M. International Journal of Pharmaceutics 83 (1992) 59 - 63
Design and evaluation of sustained release tablets of lithium in a fat matrix and its bioavailability in humans.
Llabrés, M., Fariña, J. Journal of Pharmaceutical Sciences 80 (1992) 1012 - 1016
Optimization of dl - PLA molecular weight via response surface method. Munguía, O., Delgado, A., Fariña,
J., Llabrés, M. International Journal of Pharmaceutics 86 (1992) 107 - 111
Effect of polimerization variables on PLGA properties: molecular weight, composition and chain structure.
Dorta, M. J., Munguía, O., Llabrés, M. International Journal of Pharmaceutics 100 (1993) 9 - 14
Lactoyl - lactic acid determination in dl - lactide as starting material in the synthesis of polilactic acid. Díaz,
A., Munguía, O., Fariña, J., Llabrés, M. Drug Development & Industrial Pharmacy 21 (1995) 1697 - 1703
Release control of albumin from polylactic acid microspheres. Soriano, I., Llabrés, M., Evora, C. M.
International Journal of Pharmaceutics 125 (1995) 223 - 230
Optimization of 7 - days release (in vitro) from DL - PLA methadone microspheres. Delgado, A., Evora, C.
M., Llabrés, M. International Journal of Pharmaceutics 134 (1996) 203 - 211
Separación por HPLC de los productos de degradación de la insulina en preparados comerciales. Oliva, A.
M., Fariña, J., Llabrés, M. Industria Farmacéutica 1 (1996) 43 - 48
Degradation of dl - PLA methadone base microspheres during in vitro release studies. Delgado, A., Evora, C.
M., Llabrés, M. International Journal of Pharmaceutics 140 (1996) 219 - 227
Influence of temperature and shaking on stability of insuline preparations: degradation kinetics. Oliva, A. M.,
Fariña, J., Llabrés, M. International Journal of Pharmaceutics 143 (1996) 163 - 170
Preparation and evaluation of polypeptide loaded dl - PLA microspheres using a experimental design.
Soriano, I., Evora, C. M., Llabrés, M. International Journal of Pharmaceutics 142 (1996) 135 - 142
Effect of surfactant agents on the release of 125 I bovine calcitonin from PLGA microspheres: in vivo - in
vitro study. Díaz, R. V., Soriano, I., Delgado, A., Llabrés, M., Evora, C. Journal of Controlled Release 43
(1997) 59 - 64
Analysis of peptides and proteins: evaluation of purity, stability and structural characterization of insuline.
Oliva, A. M., Fariña, J., Llabrés, M. Drug Development & Industrial Pharmacy 23 (1997) 1 - 13
Effect of storage on the stability of dl - PLA microospheres containing methadone. Delgado, A., Evora, C.
M., Llabrés, M. International Journal of Pharmaceutics 166 (1997) 223 - 225
Fingerprint analysis of insuline: application in stability studies of pharmaceutical preparations. Oliva, A. M.,
Fariña, J., Llabrés, M. Drug Development & Industrial Pharmacy 23 (1997) 127 - 132
Stability indicating high perfomance liquid chromatography methods for 5-fluorouridine in aqueous solution.
Dorta, M. J., Munguía , O., Fariña, J. B., Martín, V. S., Llabrés, M. Arzneimittel-Forschung/Drug Research
47 (1997) 1388-1392
Stability study of human serum albumin pharmaceutical preparations. Oliva, A. M., Santoveña, A., Llabrés,
M., Fariña, J. Journal of Pharmacy and Pharmacology 51 (1999) 385 - 392
Comparative degradation study of biodegradable microspheres of poly (dl - lactide - co - glycolide) with
poly (ethylenglycol) derivatives. García, J., Fariña, J., Munguía, O., Llabrés, M. Journal of
Microencapsulation
16 (1999) 83 - 94
One - month sustained release microspheres of 125-I-bovine calcitonin. In vitro - in vivo studies. Díaz, R. V.,
Llabrés, M., Evora, C. Journal of Controlled Release 59 (1999) 55 - 62
Kinetic model for 5 - fluorouridine degradation: catalitic effect of 5 - fluorouracile . Dorta, M. J., Munguía,
O., Llabrés, M. Arzneimittel-Forschung/Drug Research 50 (2000) 858 - 861
Statistical assessment of between batch stability equivalence. Llabrés, M., Oliva, A. M., Fariña, J.
International Journal of Pharmaceutics 204 (2000) 61 - 68
Development of two high-perfomance liquid chromatographic methods for the analysis and characterization
of insulin and its degradation products in pharmaceutical preparations. Oliva, A., Fariña, J., Llabrés, M.
Journal of Chromatography B 749 (2000) 25 - 34
Comparative study of protein molecular weight by size exclusion chromatography and laser - light scatering.
Oliva, A. M., Llabrés, M., Fariña, J. Journal of Pharmaceutical and Biomedical Analysis 25 (2001) 833 -
841
In vivo - in vitro study of biodegradable methadone delivery systems. Negrín, C. M., Delgado, A., Llabrés,
M., Évora, C. Biomaterials 22 (2001) 563 - 570
Potential applications of PLGA film implants in modulating in vitro drug release. Dorta, M. J., Santoveña,
A., Llabrés, M. y Fariña, J. B. International Journal of Pharmaceutics 248 (2002) 149 - 156
Chromatography characterization of synthetic peptides: SPf66 malaria vaccine. Santoveña, A., Oliva, A. M.,
Guzmán, F., Patarrollo, M. E., Llabrés, M., Fariña, J. Journal of Chromatography B 766 (2002) 3 - 12
In vitro release of fluoropyrimidines from PLGA film implants. Dorta, M. J., Oliva, A. M., Munguía, O.,
Llabrés, M., Fariña, J. Journal of Pharmacy and Pharmacology 54 (2002) 757 - 763
Biodegradable laminar implants for sustained release of recombinant human growth hormone. García, J. T.,
Dorta, M. J., Munguía, O., Llabrés, M., Fariña, J. Biomaterials 23 (2002) 4759 - 4764
Comparison of shelf-life estimates for a human insulin pharmaceutical preparation using the matrixed and
full testing approaches. Oliva, A., Fariña, J., Llabrés, M. Drug Development & Industrial Pharmacy 29
(2003) 513 - 521
Effect of high shear rate on stability of proteins: kinetic study. Oliva, A., Santoveña, A., Fariña, J., Llabrés,
M. Journal of Pharmaceutical and Biomedical Analysis 33 (2003) 145 - 155
New approach to stability assessment of protein solution formulations by differential scanning calorimetry.
Cueto, M., Dorta, M. J., Munguía, O., Llabrés, M. International Journal of Pharmaceutics 252 (2003) 159 -
166
Methadone implants for methadone maintenance treatment. In vitro and in vivo animals study. Negrín, C.
M., Delgado, A., Llabrés, M., Evora, C.M.,. Journal of Controlled Release 95 (2004) 413 - 421
Rheological properties of PLGA film based implants: correlation with polymer degradation and Spf66
antimalaric synthetic peptide release. Santoveña, A., Alvarez-Lorenzo, C., Concheiro, A., Llabrés, M.,
Fariña, J. B. Biomaterials 25 (2004) 925 - 931
Measurement of uncertainty in peptide molecular weight determination using size-exclusion chromatography
with multi-angle laser light-scattering detection and matrix-assisted laser desorption/ionization time-of-flight
mass spectrometry. Oliva, A. M., Fariña, J. B., Llabrés, M. Analytica Chimica Acta 512 (2004) 103 - 110
Stability indicating method for SPf66 antimalarial peptide in solution. Santoveña, A., Dorta, M. J., Oliva, A.,
Llabrés, M., Patarroyo, M. E., Fariña, J. B. Drug Development & Industrial Pharmacy 30 (2004) 389 - 395
Applications of multi-angle laser light-scattering detection in the analysis of peptides and proteins. Oliva, A.,
Llabrés. M., Fariña, J. B. Current Drug Discovery Technologies 1 (2004) 229 - 242
Structural properties of biodegradable polyesters and rehological behaviour of their dispersions and films.
Santoveña, A., Alvarez-Lorenzo, C., Concheiro, A., Llabrés, M., Fariña, J. B. Journal of Biomaterial
Sciences Polymer Edition
16 (2005) 629 - 641
A mathematical model for interpreting in vitro rhGH release from laminar implants. Santoveña, A., García, J.
T., Oliva, A., Llabrés, M., Fariña, J. International Journal of Pharmaceutics 309 (2006) 38 - 43
Data analysis of kinetic modelling used in drug stability studies: isothermal versus nonisothermal analysis.
Oliva, A., Llabrés, M., Fariña, J. B. Pharmaceutical Research 23 (2006) 2595 - 2602
Evaluation of cholecystokinin (CCK-8) peptide thermal stability for use as tumoral tracer by means
isothermal and nonisothermal aproaches. Oliva, A., Hidalgo, M., Alvarez, C., Llabrés, M., Fariña, J. B.
Drug Development & Industrial Pharmacy 32 (2006) 947 - 953
Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and hydrogen
exchange combined with enzymatic digestion for the structural characterization of antimalaric Spf66 peptide.
Oliva, A., Llabrés, M., Fariña, J. B. Talanta 72 (2007) 1192 - 1198

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