Didiego

CURRICULUM VITAE
!
JOSE M. DI DIEGO
!
EDUCATION
Buenos Aires University, Argentina
Degree: M.D.
POSITIONS HELD
Research Fellow, Favaloro Foundation, Bs As, Argentina. Postdoctoral Fellow, MMRL, Utica, NY, USA. Research Scientist, MMRL, Utica, NY, USA. Program and Laboratory Manager, Experimental Cardiology Department, MMRL, Utica, NY, USA. !
ACADEMIC AND PROFESSIONAL HONORS
!Postdoctoral scholarship, Agustin and Enrique Rocca Brothers Foundation (Argentina). 1987 Perez Companc Foundation Fellowship Award (Argentina). 1988-89 !Postdoctoral fellowship, American Heart Association. 1990-1992 Grant-In-Aid, American Heart Association. 1996-1998 Grant-In-Aid, American Heart Association. 1999-2002 Grant-In-Aid, American Heart Association. 2010-2013 !First Electrophysiology Award, American Heart Association Poster Competition (Chicago, IL). 2002 !Invited Speaker at the International Congress on Electrocardiology (Montreal, Canada, June 2002; Helsinki, Finland, June 2003); the International Society of Computerized Electrocardiology (Lihue, Hawaii, USA, April 2005); Guadalajara University (Guadalajara, Mexico, May 2005), Ion Channel Symposium (Copenhagen, Denmark, May 2008), Keynote Speaker at the Mohawk Valley Heart Institute-Heart Teaching Day (Utica, NY, March 2012), UNYTE Translational Research Network (Utica, NY February 2013). !
PROFESSIONAL ACTIVITIES
!Chairman of the Education Committee, MMRL. 1994 to 1997. Chairman of the Animal Care and Use Committee, MMRL. 2011 to present. Chairman of the Stem Cell Research Oversight Committee, MMRL. 2012 to present. Adjunct Research Professor, Utica College of Syracuse University. 1994 to present. Member of Safety Committee, MMRL. 1994 to present. Member of the Cardiac Electrophysiology Society. Member of the Basic Science Council, American Heart Association. Manuscript reviewer for Circulation, American Journal of Physiology, Cardiovascular Research, Journal of Cardiovascular Electrophysiology, Journal of Electrocardiology, Journal of Molecular and Cellular Cardiology, Heart Rhythm Journal, Basic Research in Cardiology, Pacing and Clinical Electrophysiology. !
PUBLICATIONS
ABSTRACTS
1. Gimeno G, Quinteiro R, Di Diego JM: Amiodarone on the ventricular instability of acute
myocardial ischemia. (X National Congress of Cardiology; Rosario, Santa Fe, Argentina, 1986). ! 2. Gimeno G, Quinteiro R, Di Diego JM: Effects of amiodarone on occlusion and reperfusion
arrhythmias. (X National Congress of Cardiology; Rosario, Santa Fe, Argentina, 1986). ! 3. Quinteiro R, Gimeno G, Di Diego JM: Effects of ischemia and reperfusion on changes in
refractoriness and conduction elicited by amiodarone. (Argentina Society of Clinical Research; Mar del Plata, Bs As, Argentina, 1986). ! 4. Di Diego JM and Antzelevitch C: The electrophysiologic effects of Amiloride in canine
ventricular myocardial tissues. FASEB J 4: A-562, 1990. ! 5. Di Diego JM and Antzelevitch C: Pinacidil-induced reentrant arrhythmias in isolated canine
ventricular epicardium. Circulation 1990;82, III-528. ! 6. Di Diego JM and Antzelevitch C: The role of the ATP-sensitive potassium currents in the
genesis of cardiac arrhythmias. Proceeding of the SUNY HSC Fourth Annual Poster Session, pg.112, 1990. ! 7. Di Diego JM and Antzelevitch C: Antiarrhythmic effects of 4-Aminopyridine (4-AP) and
glyburide in isolated canine ventricular myocardium. Pace 14:4, 725, 1991. ! 8. Di Diego JM and Antzelevitch C: Pinacidil-induced reentrant arrhythmias in isolated canine
ventricular epicardium. Proceeding of the American Physiological Society (APS) Conference: From Channels to Cross Bridges; 1991. ! 9. Lukas A, Di Diego JM and Antzelevitch C: The effects of outward channel current blockers on
reentrant arrhythmias induced by simulated ischemia in canine ventricular epicardium. First Annual Meeting of the Upstate Ney York Cardiac Electrophysiology Society; 1991. ! 10.Di Diego JM and Antzelevitch C: Amiloride Suppression of Pinacidil-induced Reentrant
Arrhythmias in Isolated Canine Ventricular Myocardium. Circulation 84:II-551, 1991. ! 11.Di Diego JM, Sicouri S, Litovsky S and Antzelevitch C: Two Components of the Transient
Outward Current in Canine Ventricular Epicardium: Right versus Left. Circulation 84:II-179, 1991. ! 12.Di Diego JM, Sicouri S, Litovsky S and Antzelevitch C: Two Components of the Transient
Outward Current in Canine Ventricular Epicardium: Right versus Left. Proceedings of the Poster Competition, SUNY Health Science Center at Syracuse, 1991. 13.Di Diego JM and Antzelevitch C: High [Ca2+]o-induced electrical heterogeneity and ectopic
activity in canine ventricular myocardium. Circulation 86:I-301, 1992. 14.Zygmunt AC, Gibbons WR, Heppner T, Di Diego JM: Calcium-activated Cl- currents in
mammalian hearts. J Mol and Cell Cardiolgy 26:S16, 1994. ! 15.Antzelevitch C, Lukas A, Di Diego J, Sicouri S, Yan GX. Reentry caused by heterogeneities
between epicardial, endocardial and midmyocardial sites: Pharmacological modification. Proc 2nd Workshop on Antiarrhythmic Drugs and Self Ventricular Defibrillation, Slovak Republic, 1995. ! 16.Di Diego JM and Antzelevitch C: Ica inhibition and IK-ATP activation induce a transmural
dispersion of repolarization resulting in ST segment elevation and arrhythmias. PACE 20:II-1134, 1997. ! 17.Di Diego JM and Antzelevitch C: Beat-to-beat alternation of transmural dispersion of
repolarization underlies ST-T wave alternans that develops during ischemia. PACE, 22:4, 251; 1999. ! 18.Di Diego JM, Feiner JM, Moussallem CG and Antzelevitch C: Cellular Basis for Ischemia-
induced ST-segment Elevation. PACE 24:II-599, 2001. ! 19.Di Diego JM, Cordeiro JM, Goodrow RJ, Fish JM, Zygmunt AC, Pérez GJ, Scornik FS and
Antzelevitch C. Ionic and Cellular Basis for the Predominance of the Brugada Syndrome Phenotype in Males. Circulation II-21:102, 2002. ! 20.Fish JM, Di Diego JM, Zygmunt AC, Antzelevitch C. Cellular and ionic basis for the sex-
related difference in the manifestation of the Brugada phenotype and progressive conduction defects. Circulation II-153:771, 2002. ! 21.Di Diego JM and Antzelevitch C. Electrophysiologic Basis for Ischemia-induced ST Segment
Elevation. PACE; April 2003, vol 6, p. 1043. ! 22.Fish JM, Di Diego JM, Tsuboi M and Antzelevitch C. Epicardial Stimulation Prolongs QT
Interval and Amplifies Transmural Dispersion of Repolarization in the Arterially Perfused Canine Left Ventricular Wedge. PACE; April 2003, vol 6, p. 1086. 23.Guerchicoff, A, G. D. Pollevick, J. M. Cordeiro, R. Dumaine, M. Mazza, C. Antzelevitch and J. M. Di Diego. Transmural Differences in Expression of SCN5A may Contribute to the Greater
Sensitivity of Ventricular Epicardium to Electrical Depression. Heart Rhythm 2006; 3(5):S302.
!24.Burashnikov A, Di Diego JM, Belardinelli L and Antzelevitch C: Ranolazine Suppresses Atrial
Fibrillation by Exerting a Marked Use-dependent Block of Sodium Channel Current in Canine Atrium but not Ventricle. Heart Rhythm 2006; 3(5):S304. 25.Renodin DM, Murphy L, Antzelevitch C, Di Diego JM, Cordeiro JM. Ischemic conditions cause
a differential depression of sodium current in the canine left ventricle. Biophys J. 94(suppl), B322. 2008. 26.Calloe K, Cordeiro JM, Di Diego JM, Grunnet M, Olesen SP, Antzelevitch C. NS5806
Activates the Transient Outward Potassium Current in the Canine Ventricle and Provides a New Model of the Brugada Syndrome. Biophysical Journal 2009; 666a: 3438-Pos. ! 27.Burashnikov A, Di Diego JM, Linhardt G, Carlsson L, Antzelevitch C. AZD1305 has atrial-
predominant electrophysiologic actions and is effective in suppressing atrial fibrillation in the dog. Heart Rhythm 2009;6:1685. 28.Burashnikov A, Di Diego JM, Linhardt G, Carlsson L, Antzelevitch C. AZD1305 has atrial-
predominant electrophysiological actions and is effective in suppressing atrial fibrillation in the dog. In: Program and abstracts of the 19th Annual Meeting of the Upstate New York Cardiac Electrophysiology Society; October 2009; Ithaca, NY, 2009. ! 29.Burashnikov A, Sicouri S, Di Diego JM, Belardinelli L, Antzelevitch C. Synergistic effect of
the combination of dronedarone and ranolazine to suppress atria fibrillation. Heart Rhythm. 2010;7:1710. 30.Calloe K, Lundby A, Jespersen T, Chlus N, Nof E, Schmitt N, Grunnet M, Di Diego JM,
Antzelevitch C, Olesen SP, Cordeiro JM. The transient outward potassium channel activator NS5806 exerts differential effect in canine atrial and ventricular cells. Acta Physiologica Scand. 2010:198:47-48. Abstract P-Sun-6 31.Minoura Y, Di Diego JM, Barajas-Martinez H, Zygmunt AC, Hu D, Sicouri S, Antzelevitch C.
Cellular mechanisms underlying the effects of antidepressants to unmask the Brugada syndrome. In: Program and abstracts of the 20th Annual Meeting of the Upstate New York Cardiac Electrophysiology Society; October 22, 2010; Utica, NY. 32.Minoura Y, Di Diego JM, Barajas-Martinez H, Zygmunt AC, Hu D, Antzelevitch C. Cellular
mechanisms underlying the effects of antidepressants to unmask the Brugada syndrome. Circulation. 2010;121:a17091. 33.Murphy L, Renodin DM, Antzelevitch C, Di Diego JM, Cordeiro JM. (2011) Extracellular
proton modulation of peak and late sodium current in the canine left ventricle. Biophysical
Journal; Vol. 100; Page 574, 2011. Di Diego, J M; Doss, MX; Goodrow, R; Wu, Y; Cordeiro,
JM; Treat, J; Antzelevitch, C.
34.Di Diego JM, Doss MX, Goodrow RJ, Wu Y, Treat J, Antzelevitch C. Effect of e-4031, pinacidil and isoproterenol on action potential characteristics and contractility in hiPS-derived cardiomyocytes. Proceedings of NYSTEM meeting, 2011. ! 35.Medei E, Doss MX, Sicouri S, Di Diego JM, Goodrow RJ, Wu Y, Treat J, Antzelevitch C. Development of early and delayed afterdepolarization activity in human iPS cardiomyocytes. Proceedings of NYSTEM meeting, 2011. 36.Di Diego, J M; Doss, MX; Goodrow, R; Wu, Y; Cordeiro, JM; Treat, J; Antzelevitch, C. Role
of IKr in maintaining resting membrane potential in human iPS-cardiomyocytes. Heart Rhythm, 8:1822-1823, 2011. 37.Calloe, K, Di Diego, JM, Moise NS, Olesen SP, Antzelevitch C, Cordeiro JM. Effects of
pharmacological activation of the transient outward potassium current during heart failure. Proceedings of Upstate New York Cardiac Electrophysiology Society (UNYCES), Gordon K. Moe Young Investigator Award, October 28, 2011. 38.Cordeiro JM, Calloe K, Giannandrea D, Di Diego, JM, Moise NS, Antzelevitch, C.
Physiological effects of transient outward k+ current activation during heart failure in the canine left ventricle. Biophys J, 2012;102:340a. 1725-Pos Board B495. 39.Doss MX, Di Diego JM, Goodrow R, Wu Y, Cordeiro JM , Nesterenko VV, Barajas-Martinez H,
Hu D, Urrutia J, Treat JA, Sachinidis A, Antzelevitch C. Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Depends Critically on IKr. Proceedings of NYSTEM meeting, 2012. 40.Sicouri S, Cordeiro JM, Di Diego JM, Nesterenko VV, Goodrow R, Treat J, Doss MX,
Antzelevitch C. Characteristics of the transient outward K+ current and its contribution to the action potential in TO THE ACTION POTENTIAL IN hiPSC-derived Cardiomyocytes. Proceedings of NYSTEM meeting, 2012. 41.Burashnikov A, Di Diego JM, Moise NS, Kornreich BG, Belardinelli L, Antzelevitch C.
Ranolazine causes atrial-selective electrophysiological effects and suppresses the induction of atrial fibrillation in a canine model of heart failure. Heart Rhythm. 2012;9:1914. 42.Koncz I, Panama BK, Di Diego JM, Gurabi Z, Szel T, Patocskai B, Hu D, Barajas-Martinez H,
Antzelevitch C. Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome. In: Program and abstracts of the 22nd Annual Meeting of the Upstate New York Cardiac Electrophysiology Society; October 26, 2012; Rochester, NY. 43.Panama BK, Minoura Y, Di Diego JM, Betzenhauser M, Nesterenko VV, Barajas-Martinez H,
Hu D, Antzelevitch C. Effect of Wenxin Keli and quinidine to suppress arrhythmogenesis in an experimental model of Brugada syndrome. In: Program and abstracts of the 22nd Annual Meeting of the Upstate New York Cardiac Electrophysiology Society; October 26, 2012; Rochester, NY. 44.Cordeiro JM, Nesterenko VV, Goodrow RJ, Sicouri S, Treat JA, Doss MX, Antzelevitch C, Di Diego JM. Characterization of a transient outward K+ current in hiPS-derived
cardiomyocytes. Biophys J. 2013;104:298a. Abstract 1526-Pos.
45.Burashnikov A, Di Diego JM, Belardinelli L, Antzelevitch C. Atria are more sensitive than
ventricles to inhibition of late sodium current by GS-458967 but block of this current is not effective in suppressing acetylcholine-mediated atrial fibrillation. Heart Rhythm. 2013;10:S328. Abstract PO4-98. ORIGINAL PAPERS and INVITED REVIEWS
1. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA,
Liu DW. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res. 1991;69:1427-1449. 2. Antzelevitch C, Di Diego JM. Role of K+ channel activators in cardiac electrophysiology and
arrhythmias. Circulation. 1992;85:1627-1629. 3. Di Diego JM, Antzelevitch C. Pinacidil-induced electrical heterogeneity and extrasystolic
activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry? Circulation. 1993;88:1177-1189. 4. Di Diego JM, Antzelevitch C. High [Ca2+]-induced electrical heterogeneity and extrasystolic
activity in isolated canine ventricular epicardium. Phase 2 reentry. Circulation. 1994;89:1839-1850. 5. Antzelevitch C, Sicouri S, Lukas A, Nesterenko VV, Liu DW, Di Diego JM. Regional
differences in the electrophysiology of ventricular cells: physiological and clinical implications. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 2 ed. Philadelphia: W.B. Saunders Co.; 1994:228-245. 6. Antzelevitch C, Sicouri S, Lukas A, Di Diego JM, Nesterenko VV, Liu DW, Roubache JF,
Zygmunt AC, Zhang ZQ, Iodice A. Clinical implications of electrical heterogeneity in the heart: the electrophysiology and pharmacology of epicardial, M, and endocardial cells. In: Podrid PJ, Kowey PR, eds. Cardiac Arrhythmia: Mechanism, Diagnosis and Management.Baltimore, MD: William & Wilkins; 1995:88-107. 7. Antzelevitch C, Di Diego JM, Sicouri S, Lukas A. Selective pharmacological modification of
repolarizing currents: antiarrhythmic and proarrhythmic actions of agents that influence repolarization in the heart. In: Breithardt J, Borggrefe M., Camm J, Shenasa M, eds. Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions. 1 ed. Berlin: Springer-Verlag; 1995:57-80. 8. Di Diego JM, Sun ZQ, Antzelevitch C. Ito and action potential notch are smaller in left vs.
right canine ventricular epicardium. Am J Physiol. 1996;271:H548-H561. 9. Antzelevitch C, Nesterenko VV, Shimizu W, Di Diego JM. Electrophysiological
characteristics of the M cell. In: Franz MR, Schmitt C, Zrenner B, eds. Monophasic Action Potentials.Berlin: Springer; 1997:212-226. 10.Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, Burashnikov A, Di Diego JM, Saffitz J, Thomas GP. The M cell: its contribution to the ECG
and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol.
1999;10:1124-1152.
11.Di Diego JM, Cordeiro JM, Goodrow RJ, Fish JM, Zygmunt AC, Peréz GJ, Scornik FS,
Antzelevitch C. Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation. 2002;106:2004-2011. 12.Antzelevitch C, Burashnikov A, Di Diego JM. Cellular and ionic mechanisms underlying
arrhythmogensis. In: Gussak I, Antzelevitch C, eds. Cardiac Repolarization. Bridging Basic and Clinical Sciences.Totowa, NJ: Humana Press; 2003:201-251. 13.Di Diego JM, Belardinelli L, Antzelevitch C. Cisapride-induced transmural dispersion of
repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation. Circulation. 2003;108:1027-1033. 14.Di Diego JM, Antzelevitch C. Cellular basis for ST-segment changes observed during
ischemia. J Electrocardiol. 2003;36 Suppl:1-5. 15.Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM,
Cordeiro JM, Thomas GP. Electrophysiologic effects of ranolazine: a novel anti-anginal agent with antiarrhythmic properties. Circulation. 2004;110:904-910. PMCID: PMC1513623 16.Antzelevitch C, Belardinelli L, Wu L, Fraser H, Zygmunt AC, Burashnikov A, Di Diego JM,
Fish JM, Cordeiro JM, Goodrow RJ, Jr., Scornik F, Perez G. Electrophysiologic properties and antiarrhythmic actions of a novel anti-anginal agent. J Cardiovasc Pharmacol Therapeut. 2004;9 Suppl 1:S65-S83. PMID:15378132 17.Antzelevitch C, Fish J, Di Diego JM. Cellular mechanisms underlying the Brugada syndrome.
In: Antzelevitch C, Brugada P, Brugada J, Brugada R, eds. The Brugada Syndrome: From Bench to Bedside.Oxford: Blackwell Futura; 2004:52-77. 18.Fish JM, Di Diego JM, Nesterenko VV, Antzelevitch C. Epicardial activation of left
ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing. Circulation. 2004;109:2136-2142. PMID:15078801 19.Di Diego JM, Fish JM, Antzelevitch C. Brugada syndrome and ischemia-induced ST-segment
elevation. Similarities and differences. J Electrocardiol. 2005;38:14-17. PMCID: PMC1473215 20.Vernooy K, Delhaas T, Cremer OL, Di Diego JM, Oliva A, Timmermans C, Volders PG,
Prinzen FW, Crijns HJ, Antzelevitch C, Kalkman CJ, Rodriguez LM, Brugada R. Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. Heart Rhythm. 2006;3:131-137. PMCID1474111 21.Antzelevitch C, Burashnikov A, Di Diego JM. Mechanisms of Cardiac Arrhythmia. In:
Electrical Diseases of the Heart and Sudden Cardiac Death –Mechanisms –Treatment – Prevention. Eds, I. Gussak and C. Antzelevitch. Springer, UK, 2007. 22.Burashnikov A, Di Diego JM, Zygmunt A, Belardinelli L, Antzelevitch C. Atrial-selective
sodium channel block as a strategy for suppression of atrial fibrillation. Second ISHNE Atrial Fibrillation World-Wide Internet Symposium; April 2007; http://www.af-symposium.org. 23.Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective
sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 2007;116:1449-1457. PMCID2566303 24.Shinde R, Shinde S, Makhale C, Grant P, Sathe S, Durairaj M, Lokhandwala Y, Di Diego J,
Antzelevitch C. Occurrence of "J waves" in 12-lead ECG as a marker of acute ischemia and their cellular basis. PACE. 2007;30:817-819. PMCID1989774 25.Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W, Yan GX,
Kowey P, Zhang L. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007;4:1114-1116. PMCID1994816 26.Cordeiro JM, Malone JE, Di Diego JM, Scornik FS, Aistrup GL, Antzelevitch C, Wasserstrom
JA. Cellular and subcellular alternans in the canine left ventricle. Am J Physiol Heart Circ Physiol. 2007;293:H3506-H3516. PMCID2366895 27.Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrial-selective
sodium channel block as a strategy for suppression of atrial fibrillation. Ann N Y Acad Sci. 2008;1123:105-112. PMCID2366169 28.Cordeiro JM, Mazza M, Goodrow R, Ulahannan N, Antzelevitch C, Di Diego JM.
Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression. Am J Physiol Heart Circ Physiol. 2008;295:H154-H162. PMCID: PMC2494739 29.Burashnikov A, Di Diego JM, Sicouri S, Ferreiro M, Carlsson L, Antzelevitch C. Atrial-
selective effects of chronic amiodarone in the management of atrial fibrillation. Heart Rhythm. 2008;5:1735-1742. PMCID2640450 30.Calloe K, Cordeiro JM, Di Diego JM, Hansen RS, Grunnet M, Olesen SP, Antzelevitch C. A
transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc Res. 2009;81:686-694. PMCID2642600. ! 31.Burashnikov A, Zygmunt AC, Di Diego JM, Linhardt G, Carlsson L, Antzelevitch C.
AZD1305 exerts atrial-predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its re-induction in the dog. J Cardiovasc Pharmacol, 2010(56):80-90. PMC2905470 ! 32.Wilde AA, Postema PG, Di Diego JM, Viskin S, Morita H, Fish JM, Antzelevitch C. The
pathophysiological mechanism underlying Brugada syndrome. Depolarization versus repolarization. J Mol Cell Cardiol, 49:543-553, 2010. PMC2932806 ! 33.Burashnikov A, Sicouri S, Di Diego JM, Belardinelli L, Antzelevitch C. Synergistic effect of
the combination of dronedarone and ranolazine to suppress atrial fibrillation. J Am Coll Cardiol. 2010;56:1216-1224. PMC2951276 ! 34.Di Diego JM. Current-to-Load Mismatch, Brugada ECG Pattern and the Associated
Arrhythmogenesis. Editorial Commentary. Heart Rhythm, 2011;8:119-120. PMID: 2092061. PMID:20920601 35.Murphy, L; Renodin, D; Antzelevitch, C; Di Diego, JM; and Cordeiro, JM. Extracellular
proton depression of peak and late Na current in the canineleft ventricle. Am J Physiol Heart Circ Physiol 301: H936–H944, 2011. PMID:21685271 36.Calloe K, Nof E, Jespersen T, Di Diego JM, Chlus N, Olesen SP, Antzelevitch C, Cordeiro J.
Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes. J Cardiovasc Electrophysiol. 2011;22:1057-1066. PMCID3136585 37.Di Diego JM and Antzelevitch C. Ischemic Ventricular Arrhythmias: Experimental Models
and Clinical Relevance. Heart Rhythm 2011;8:1963–1968. PMID:21740880 38.Minoura, Y; Di Diego, JM; Barajas-Martinez, H; Zygmunt, A; Hu, D; Sicouri, S; Antzelevitch,
C. Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. J Cardiovasc Electrophysiol. 2012;23:423–432. PMCID3468832 39.Cordeiro JM, Calloe K, Moise NS, Kornreich B, Giannandrea D, Di Diego JM, Olesen SP,
Antzelevitch C. Physiological consequences of transient outward K+ current activation during heart failure in the canine left ventricle. J Mol Cell Cardiol. 2012;52:1291–1298. PMCID3401930 40.Doss MX, Di Diego JM, Goodrow R, Wu Y, Cordeiro JM , Nesterenko VV, Barajas-Martinez
H, Hu D, Urrutia J, Treat JA, Sachinidis A, Antzelevitch C. Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Depends Critically on IKr. (2012) PLoS ONE 7(7): e40288. doi:10.1371/journal.pone.0040288. PMCID3396384. 41.Picón R, Di Diego JM, Antzelevitch C. Descripción de la utilización de cuñas ventriculares
aisladas de corazón canino en el laboratorio de electrofisiología experimental. [The use of isolated canine ventricular wedge preparations in the experimental electrophysiology laboratory] Cardiocore. 7:124-131, 2012. 42.Di Diego JM. The Isolated Ventricular Wedge Preparation: A Valid Proof of Relevance.
Editorial Commentary. Heart Rhythm. 2012;9:1716-1717. 43.Di Diego JM, Sicouri S, Myles RC, Burton FL, Smith GL and Antzelevitch C. Optical and
Electrical Recordings from Isolated Perfused Canine Ventricular Wedge Preparations. Methodological Review. J Mol Cell Cardiol. 2013;54:53–64. PMCID3535682 44.Jesty S, Jung SW, Cordeiro JM, Gunn T, Di Diego JM, Hemsley S, Kornreich B, Antzelevitch
C, Moise NS. Cardiomyocyte calcium cycling in a naturally occurring German shepherd dog model of inherited ventricular arrhythmia and sudden cardiac death. Journal of Veterinary Cardiology (2013) 15, 5-14. NIHMSID510226 45.Cordeiro JM, Nesterenko VV, Sicouri S, Goodrow RJ, Treat JA, Desai M, Doss MX, Antzelevitch C, Di Diego JM. Identification and characterization of a transient outward K+
current in human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol.
2013; 60 (36-46). PMCID3779808
46.Minoura Y, Panama BK, Nesterenko VV, Betzenhauser M, Barajas-Martínez H, Hu D, Di
Diego JM, Antzelevitch C. Effect of Wenxin Keli and quinidine to suppress arrhythmogenesis
in an experimental model of Brugada syndrome. Heart Rhythm. 2013;10:1054-1062.
PMCID3702731
47.Burashnikov A, Di Diego JM, Sicouri S, Doss MX, Sachinidis A, Barajas-Martinez H, Hu D,
Minoura Y, Moise NS, Kornreich BG, Chi L, Belardinelli L, Antzelevitch C. A Temporal Window of Vulnerability for Development of Atrial Fibrillation with Advancing Heart Failure. European Journal of Heart Failure (2013; in press). PMC Journal - In Process 48.Cordeiro JM, Panama BP, Goodrow R, Zygmunt AC, White C, Treat JA, Nesterenko VV, Di
Diego JM, Burashnikov A, Antzelevitch C. Developmental changes in expression and
biophysics of sodium and potassium channels in the canine ventricle. J Mol Cell Cardiol
2013;64:79-89. PMC Journal - In Process

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