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The 59th annual Montagna Symposium on the Biology of Skin presents

Ewout M. Baerveldt1,2
, Armanda J. Onderdijk1,2, Chris Wohn2, Marius Kant1,2, Eddy F.
Florencia1,2, Jon D. Laman2, H. Bing Thio1, Johann E. Gudjonsson2, Errol P. Prens1,2
1Departments of Dermatology and 2Immunology, Erasmus MC, Rotterdam, The Netherlands
3Department of Dermatology, University of Michigan, Ann Arbor, MI
Nerve growth factor regulation by Th17/IL23 in murine psoriasis-like model and human
uninvolved psoriatic skin
Paulo R. Bargo
, Melissa Chu, Inseok Seo, Guojin Zhang, Nikiforos Kollias
Johnson & Johnson Consumer Companies
In vivo
assessment of the evolution of UV-induced immune responses in human skin
Elhabib Benlhabib1
, M. K. Hordinsky1, A. C. Junqueira Bertin1, I. G. Panoutsopoulou1,3, G.
Wendelschafer-Crabb3, W. R. Kennedy3, G. L. Wilcox1,2
Departments of 1Dermatology, 2Neuroscience and 3Neurology, University of Minnesota,
Minneapolis, MN
Long-term exposure to sun (UVB) induces skin cancer, premature skin aging and cutaneous
Jamie J. Bernard
, Richard L. Gallo
Division of Dermatology, University of California, San Diego
Cox-2 activity is required for enhanced antimicrobial peptide expression and bacteriocidal
activity in human keratinocytes

Ferda Cevikbas1
, Xidao Wang2, Akihiko Ikoma1, Victoria Fong1, Stephan Seeliger3, Stacey R.
Dillon4, Michael Fischer5, Peter Reeh 5, Attila Antal6, Bernhard Homey6, Allan Basbaum2, Martin
Departments of 1Dermatology, Surgery and 2Anatomy, University of California, San Francisco,
3Department of Pediatrics, University of Goettingen, Germany
4ZymoGenetics, Inc., Seattle, WA
5Department of Physiology, University of Erlangen, Germany
6Department of Dermatology, University of Duesseldorf, Germany

Interleukin-31 induces scratching in mice via IL-31RA/OSMRβ activation in untreated as
well as oxazolone-sensitized skin
Melanie C. Dispenza,
Amanda M. Nelson, Kathryn L. Gilliland, Zhaoyuan Cong, Amy L.
Longanecker, LeRoy J. Tanner, Diane M. Thiboutot
Dept of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA
Immune modulation by isotretinoin in vivo
José R. Fernández, Xuyan Feng, Eduardo Pérez, Karl Rouzard, Arnold González, Seung-Yub
Lee, Michael Voronkov, Gopal Sarngadharan, Joel S. Gordon, Maxwell Stock
Signum Biosciences, Inc., Monmouth Junction, NJ
Isoprenylcysteine (IPC) analogs, G-protein CAAX tail mimics, are a new class of topical
anti-inflammatories with a low potential for adverse effects
Akihiko Ikoma1
, Ferda Cevikbas1,2, Victoria Fong1, Eric Camerer3, Shaun R. Coughlin3, Martin
1Departments of Dermatology, 2Surgery and 3 Cardiovascular Research Institute, University of
California, San Francisco, CA
4 Cardiovascular Research Center, INSERM, Paris, France
Conditional over-expression of protease-activated receptor-2 in murine keratinocytes
results in pruritic dermatitis with increased nerve growth factor release in vivo

Zhixing Wang1, Jay Kirkwood1, Fred Stevens1, Mark Leid1,2, Gitali Ganguli-Indra1, Arup
1Department of Pharmaceutical Sciences, College of Pharmacy, 2Molecular and Cellular Biology
Program, 3Environmental Health Science Center, Oregon State University, Corvallis, OR
4Department of Dermatology, Oregon Health and Science University, Portland, OR
Transcription factor Ctip2/ Bcl11b regulates skin lipid metabolism and plays a crucial role
in formation of epidermal permeability barrier (EPB)

Rosane Teles1, Andrew Chung1, Saeid Ghavami2, Huiying Li3, Xinmin Li4, Delphine J. Lee1
1Division of Dermatology, Dept of Medicine, 2Dept of Pathology & Laboratory Medicine, David
Geffen School of Medicine and 3Crump Institute for Molecular Imaging, Dept of Molecular and
Medical Pharmacology, UCLA-DOE Institute for Genomics and Proteomics, University of
California, Los Angeles, CA
4Dept of Physiology, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada
Gene expression profiles at the site of disease reveal a role for S100A8 /A9 in promoting
melanocyte loss in vitiligo

Kimberly R. Lumsden1, Amanda M. Nelson2, Melanie Dispenza3, Kathryn L. Gilliland2,
Zhaoyuan Cong2, Diane M. Thiboutot1,2
1Jake Gittlen Cancer Research Foundation, Departments of 2Dermatology and 3Molecular and
Cellular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA
NGAL expression is induced by P. acnes and isotretinoin in sebocytes and increased on the
skin surface of acne patients and patients receiving isotretinoin
Heather McGee
, Richard Flavell, Valerie Horsley
Departments of Immunobiology, and Molecular, Cellular and Developmental Biology, Yale
University, New Haven, CT
Role of Interleukin-22 in acute skin wounding
Jun Muto1
, Lionel Breton2, Richard L. Gallo1
1Division of Dermatology, University of California, San Diego
2L’Oréal Recherche, Clichy, France
A C-xylopyranoside derivative stimulates dermatan sulfate synthesis and promotes
keratinocyte migration
Amanda M. Nelson,
Zhaoyuan Cong, Kathryn L. Gilliland, Diane M. Thiboutot
Jake Gittlen Cancer Research Foundation and Department of Dermatology, Pennsylvania State
University College of Medicine, Hershey, PA
On the TRAIL to isotretinoin’s mechanism of action in acne treatment
Stephen M. Ostrowski 1,2
, Abdelmadjid Belkadi1, Candace M. Matheny2, Doina Diaconu2,
Nicole L. Ward 1,2,3
Departments of 1Neurosciences and 2Dermatology, Case Western Reserve University, Cleveland,
OH; 3The Murdough Family Center for Psoriasis, University Hospitals, Case Medical Center,
Cleveland, OH
Nerve-derived substance P (SP) and calcitonin gene related peptide (CGRP) sustain CD11c+
and CD4+ cutaneous cell infiltration and contribute to acanthosis in the KC-Tie2 mouse
model of psoriasis

So Yeon Paek1, Fumi Miyagawa1, Hong Zhang1, Jay Linton1, R. Mark Simpson2, Stephen I.
1Dermatology Branch, CCR, NCI, NIH, Bethesda, MD
2Molecular Pathology Unit, Laboratory of Cancer Biology & Genetics, NIH, Bethesda, MD
Peptide protection of the pinna: how small molecules rescue ear phenotype in a mouse
model of autoimmunity
Ioanna Panoutsopoulou1
, George L. Wilcox1,3,4, Gwen Wendelschafer-Crabb2, William R.
Kennedy2, Maria K. Hordinsky1
Departments of 1Dermatology, 2Neurology, 3Neuroscience and 4Pharmacology, University of
Minnesota, Minneapolis, MN
Suction skin blister confocal analysis of nerve fiber and Langerhans cell expression in
psoriasis and normal human skin

Amala Soumyanath1, Julia Sonka2, Kevin Phillips3,4, Steven Jacques3,4, Philippe Thuillier2
Departments of 1Neurology, 2Public Health and Preventive Medicine, 3Biomedical Engineering
and 4Dermatology, Oregon Health and Science University, Portland, OR
Melanocytic responses to piperine, a small molecule from nature

Ronald Wolf1,5
, Francesca Mascia1, Alif Dharamsi1, O.M. Zack Howard2, Christophe Cataisson1,
Val Bliskovski1, Jason Winston1, Lionel Feigenbaum4, Ulrike Lichti1,Thomas
Ruzicka5,Triantafyllos Chavakis3, Stuart H. Yuspa1
1Laboratory of Cancer Biology and Genetics, 3Experimental Immunology Branch, CCR, NCI,
NIH, Bethesda, MD
2Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, CCR, NCI,
NIH, Frederick, MD
4 Laboratory Animal Sciences Program, SAIC, Frederick, MD
5Department of Dermatology, Ludwig Maximilian University, Munich, Germany
Small S100 molecules with cutaneous antimicrobial activity prime skin for inflammation: A
mouse model for psoriasis susceptibility


(1) (2.5 marks) The weight (pounds) of n = 8 female wolves captured in theYukon-Charley National Reserve are {57, 84, 90, 71, 77, 68, 73, 72}. As-suming that the weight distribuiton of female wolves is normally distributedconstruct a 95% confidence interval for the population mean. (2) (3 marks) The weekly demand for the common antibiotic Amoxicillin (in1000’s of pills) at a pharmacy is a ran


My Dog is Broken! A Case Study in Cell Signaling Lynn Diener T-dog: Melody it’s me, Tessa. Are you at your computer? DrM: Yeah, I just fi nished with my meeting, what’s up? T-dog: I’m feeling a little depressed lately. You know how much money I spent on my new champion Yorkshire terrier, Akira Edelweiss? DrM: I still think you’re crazy for spending that much on a

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