Anti-inflammatory properties of Moringa Oleifera
There are over 46 antioxidants and 36 anti-inflammatory compounds all naturally occurring in the Moringa plant.
Antioxidants: Vitamin A, Vitamin C, Vitamin E, Vitamin K, Vitamin B (Choline), Vitamin B1 (Thiamin), Vitamin B2 (Riboflavin), Vitamin B3 (Niacin), Vitamin B6, Alanine, Alpha-Carotene, Arginine, Beta-Carotene, Beta-sitosterol, Caffeoylquinic Acid, Campesterol, Carotenoids, Chlorophyll, Chromium, Delta-5-Avenasterol, Delta-7-Avenasterol, Glutathione, Histidine, Indole Acetic Acid, Indoleacetonitrile, Kaempferal, Leucine, Lutein, Methionine, Myristic-Acid, Palmitic-Acid, Prolamine, Proline, Quercetin, Rutin, Selenium, Threonine, Tryptophan, Xanthins, Xanthophyll, Zeatin, Zeaxanthin, Zinc. Anti-inflammatory: Vitamin A, Vitamin B1 (Thiamin), Vitamin C, Vitamin E, Arginine, Beta-sitosterol, Caffeoylquinic Acid, Calcium, Chlorophyll, Copper, Cystine, Omega 3, Omega 6, Omega 9, Fiber, Glutathione, Histidine, Indole Acetic Acid, Indoleacetonitrile, Isoleucine, Kaempferal, Leucine, Magnesium, Oleic-Acid, Phenylalanine, Potassium, Quercetin, Rutin, Selenium, Stigmasterol, Sulfur, Tryptophan, Tyrosine, Zeatin, Zinc. DOST Study: Anti-inflammatory and Antitumor Activities of Seeds Extracts of Malunggay, Moringa oleifera L. (Moringgaceae)
Amelia P. Guevara, Carolyn Vargas and Milagros Uy http://www.stii.dost.gov.ph/pjsweb/data/antitumor_of_malunggay.htm
The seeds of malunggay, Moringa oleifera, were extracted with distilled ethanol and concentrated under reduced pressure at 40oC. The resulting extract was partitioned between hexane, ethylacetate, butanol and water. The solvent fractions were likewise concentrated under reduced pressure.
The crude ethanol extract of dried seeds inhibited the carrageenan-induced inflammation in the hind paw of mice by 85% at a dosage of 3 mg/g body weight while the mature green seeds by 77%The hexane fraction of the crude ethanol extract of the dried seeds also inhibited inflammation by 77% at the same dosage while both butanol and water fractions inhibited inflammation by only 34%These results indicate the strong anti-inflammatory activities of the ethanol extract and the hexane fraction.
On the other hand, the ethylacetate fraction caused a 267% increase in inflammation and exhibited toxicity. The mice died after oral administration of the fraction. The crude ethanol extract also inhibited the formation of Epstein-Barr virus-early antigen (EBV-EA) induced by 12-0-tetradecanoylphorbol-13-acetate (TPA). At a dosage of 100 ?g/ml, the extract inhibited EBV-EA formation by 100% suggesting its antitumor-promoting activity.
PUBMED: Anti-inflammatory activity of Moringa oleifera (moringaceae)] Ndiaye M, Dieye AM, Mariko F, Tall A, Sall Diallo A, Faye B. Laboratoire de Pharmacologie et de Physiologie, UCAD, BP 5005, Dakar, Seregal. Moringa oleifera is a bush of African savannah, used in folk Medicine for the treatment of rheumatic and articulary pain. We have tested the anti-inflammatory action of an aqueous extract of root in rats with weight between 120 and 160 g. We administered per os either distilled water (control group), the aqueous root extract (750 mg/kg or 1000 mg/kg) or indomethacin (10 mg/kg) 30 min before an oedema was induced in the rat- paw by subcutaneous injection of carrageenin. The rat-paw volume was measured 1, 3 and 5 hours after injection of carrageenin. At a dose of 750 mg/kg the Moringa oleifera treatment significantly inhibited the development of oedema at 1, 3 and 5 hours (reduction by 53.5, 44.6 and 51.1% respectively). Increasing the dose of Moringa oleifera to 1000 mg/kg did not increase the inhibitory effect on oedema development at 1 and 3 hours, whereas this dose potentiated the oedema at 5 hours. Treatment with indomethacin significantly inhibited the development of oedema 1, 3 and 5 hours (49.1, 82.1 and 46.9% respectively). These findings indicate that an aqueous root extract of Moringa oleifera at 750 mg/kg reduces the carrageenin induced oedema to similar extent as the potent anti-inflammatory drug indomethacin. Moreover, these results provide further evidence that the roots of Moringa oleifera contain anti-inflammatory principle that may be useful in the treatment of the acute inflammatory conditions. PMID: 15776678 [PubMed - indexed for MEDLINE] PUBMED: Antiinflammatory effects of Moringa oleifera root extract
EZEAMUZIE I. C. (1) ; AMBAKEDEREMO A. W. (1) ; SHODE F. O. ; EKWEBELEM S. C.
(1) Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat, 13110, KOWEIT
Résumé / Abstract
A crude methanol extract of the root of the plant Moringa oleifera Lam. was screened for anti inflammatory effect using the rat paw edema and the rat 6-day air pouch inflammatory models. Following oral administration, the extract inhibited carrageenan-
induced rat paw edema in a dose-dependent manner, with 50% inhibitory concentration - IC (dose producing 50% inhibition) of 660 mg/kg. On the 6-day air pouch acute inflammation induced with carrageenan, the extract was much more potent, with IC values of 302.0 mg/kg and 315.5 mg/kg, for the inhibition of cellular accumulation and fluid exudation, respectively. Maximum inhibition obtained with 600 mg/kg were 83.8% and 80.0%, respectively. When delayed (chronic) inflammation was induced in the 6-day air pouch model using Freund's complete adjuvant, the extract was still effective though less than in acute inflammation. In contrast a moderate dose of indomethacin (5 mg/kg) inhibited the acute, but not the delayed form of air pouch inflammation. Acute toxicity tests in mice suggest very low toxicity. These results suggest that the root of Moringa oleifera contains anti inflammatory principle(s) that may be useful in the treatment of both the acute and chronic inflammatory conditions.
International journal of pharmacognosy (Int. j. pharmacogn.) 1996, vol. 34, no3, pp. 207-212
Analgesic, anti-inflammatory and local anaesthetic activity of Moringa in laboratory animals
MEDHI Bandana (1) ; KHANIKOR H. N. (1) ; LAHON L. C. (1) ; MOHAN P. (1) ; BARUA C. C. (1) ;
(1) Department of Pharmacology and Toxicology, College of Veterinary Science, Guwahati, Assam, INDE
Résumé / Abstract
The methanol extract of Moringa (Moringaceae) was used to evaluate its analgesic, anti-inflammatory and local anaesthetic activity in the present study. Analgesic activity was tested in mice using various doses orally. Acetic acid-induced writhing episodes were significantly and dose-dependently reduced. At the same dose, its anti-inflammatory activity was also tested. Carrageenin (a standard inflammatory agent)-induced paw edema in mice was significantly reduced after oral administration. Furthermore, its local anaesthetic activity were tested in frog and guinea pig models, and it was seen that in both animals, the plant (root bark) produces significant local anaesthetic activity.
Pharmaceutical biology (Pharm. biol.) ISSN 1388-0209
2003, vol. 41, no4, pp. 248-252 [5 page(s) (article)] (7 ref.)
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