Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations Michael Gertz, John D. Davis, Anthony Harrison, J. Brian Houston and Aleksandra Galetin Referenced bioavailability and FG,GFJ values for 32 CYP3A substrates used in figure 1A. Accepted for publication in Curr Drug Metab, September 2008 Substrate Bioavailabilit
DocumentProven Techniques for a Successful Positive The Noble Messenger of Allah (peace be upon him) has said,"Almighty Allah says, 'I treat my
servant according to his expectations from Me, and I am with him when he remembers
me. If he remembers Me in his heart, I remember him in My heart…. if he walks towards
Me, I run unto him." (Hadith-Qudsi)
Make this Ramadan the month of "Change".Are You Ready for it???
"Change" is the vogue today. "Change" is being chanted by the Presidents to rally up public support; "Change" is being demanded by the masses suffering due to skyrocketing fuel and commodity prices; "Change", a drastic one indeed, is what we are witnessing with awe in the global weather patterns. For Muslims, Ramadan is the prime time for change. This month dramatically alters our routines and schedules. From tight sleep schedules, to hunger for extended hours, to reduction in consumption of junk foods, to a technology diet; to withdrawal from caffeine addiction, to lengthy standing in Taraweeh prayers at night, to extensive listening to the Quran. What a change indeed! Beyond Routines and Rituals
The real change, however, Ramadan demands of us is the internal change – a change that
positively transforms our lifestyle, character, attitudes, conversations, and habits. Allah has
described this change in the month of Ramadan as follows: "O you who believe, fasting has
been ordained on you as it was decreed upon those before you so that you may adopt
Taqwa" (2:183 [Quran 2:183].
Slavery to Ramadan?
If our change is limited to outer physical practices only, we become slaves to Ramadan, instead of being servants to Ar-Rahman (Allah, the Merciful). Prophet Muhammad has warned us about those who don't fast from bad behaviour: "Allah has no interest in any person's abstention from eating and drinking, if that person
does not give up lying and dishonest actions" (Sahih al-Bukhari)
Every Ramadan we make resolutions and tell ourselves: "This Ramadan will be different. I'm going to change my ______ habit." "I will give up ………", "I will take my practice of Islam to the next level". But how many of us are really able to follow through? Plenty of good intentions, many amazing wishes, but sadly enough, life goes on as usual the morning of Eid. Ask yourself, how is my fasting benefitting my spiritual connection with Allah? How is my extensive worship in Ramadan helping me discipline my tongue (taste and speech), eyes, ears, and habits? Are you ready to take that first step to transform your bad habits into good ones? Ways to Kick Bad Habits
Few things are more demanding than eliminating bad habits, since they are part of our daily routines and personality. It takes days of patience and practice to break old habits. However, the good news is, Ramadan offers a perfect and natural environment for moral training. Interestingly, researches from "positive psychology" (scientific study of successful people) have repeatedly shown it takes between 30 to 40 days to kick a bad habit and develop a new one. In addition to the physical discipline during the month of Ramadan, the increased spiritual exercise and connection with Allah, can transform your habits for life. Try these proven techniques for a successful positive change in your habits during
Ramadan and beyond!
1. Acknowledge and Identify your bad habits: First step is to admit you need to change. If
you are in a state of denial, you won't recognize that you have a bad habit to change.
2. Pick a habit for this month: Prioritize your bad habits and focus on one for this month. If
you are committed to changing at least one habit, you will see remarkable results, Allah-willing.
3. Realize that it's in us to change: Don't believe the old saying, "You can't teach an old dog
new tricks." You can break a bad habit if you really want to. No one else can change your
habits, if you don't want to.
4. Remember, Allah loves those who commit mistakes and repent: The Noble Messenger
of Allah (peace be upon him) said:
"By Him in Whose Hand is my life, if you were not to commit sin, Allah would sweep you
out of existence and He would replace (you by) those people who would commit sin and
seek forgiveness from Allah, and He would have pardoned them." (Hadith -Sahih Muslim)
5. Intention & Plan to change: "If you fail to plan, you plan to fail." A healthy process of change
in character requires a gradual pace, which entails planning. Develop concrete milestones to
measure your progress.
6. Replace a bad habit with a good one: Completely eliminating a habit is more challenging
than replacing it with a more productive habit. Moreover, it's crucial to replace the lost natural
needs, such as the need to socialize and to be entertained with something healthy.
For instance, it's easier to replace your addiction to TV with a physical workout or reading the Qur’aan or a good Islamic book etc. Interestingly, Prophet Muhammad (peace be upon him), the greatest 'psychologist' of humanity, illustrated this principle in these words: "Fear Allah wherever you may be; follow up an evil deed with a good one which will wipe
(the former) out, and behave good-naturedly towards people." (Hadith-At-Tirmidhi).
7. Change your Environment: Resist the negative peer pressure by finding a better company
of friends. Collective action to change is very powerful. Prophet Muhammad (peace be upon
him) explained this peer pressure effect with the analogy:
"A good friend and a bad friend are like a perfume-seller and a blacksmith: The perfume-
seller might give you some perfume as a gift, or you might buy some from him, or at least
you might smell its fragrance. As for the blacksmith, he might singe your clothes, and at
the very least you will breathe in the fumes of the furnace." (Hadith-Sahih al-Bukhari &
8. Exercise: Spiritual exercise is important for lasting change. You may not realize that by
exerting your yourself in spiritual exercises like the reading of Qur’an and Hadith, fasting, giving
charity, Zikr(remembering Allah),Spending time in the Path of Allah etc helps in eliminating a
number of bad habits. Through the spiritual light of doing noble deeds, evil ones will gradually
be eradicated from your life. Allah says : "Indeed, Salah restrains from Shameful and unjust
deeds" (Quran:29:45). A person complained to the Prophet Muhammad (peace be upon him)
about someone who read salaah and also committed theft .The Prophet Muhammad (peace be
upon him) said "His salaat will very soon wean him off that sin.' This shows that the evil habits
can be got rid of by adhering to good practises. The doing of good deeds such as remembering
Allah cleanses the heart. A clean heart encourages a person to do good deeds and refrains one
from evil habits!
Moreover, exercising your will power (struggle to fight temptations) for this month helps you kick all kinds of bad habits and form new good ones. Willpower is like a muscle; the more you exercise it, the more you strengthen it. 9. Think of yourself as a changed, different, new person. This simple psychological shift in
your thinking about your own image can do wonders. Tell yourself, "I can't continue this ill-
behaviour. I am better than that. I am stronger. I am wiser."
10. Reward success: The most fundamental law in all of psychology is the "law of effect." It
simply states that actions followed by rewards are strengthened and likely to recur.
Unfortunately, studies show that people rarely use this technique when trying to change
Setting up formal or informal rewards for success greatly increases your chances of transforming bad habits into good ones, and is far more effective than punishing yourself for bad habits or setbacks. As Muslims we should also remember that the ultimate reward is Allah's Pleasure and Paradise in the Hereafter. 11. Get help: Tell someone about your effort to change if it helps. He or she may keep you on
track and may offer some good advice. Read books that will encourage you to do virtues
actions. Join the various (amaal) programs in your local Musjid. Ladies should endeavour to join
their local Taalimi Halqas. There are good and sincere people who are ready to assist. We are
not an island- We are an Ummah!
12. Boost your spiritual immune system: By fasting,doing good actions,Itikaaf(seclusion),
spending time in the Musjid with the pious friends of Allah or going in the Path of Allah will boost
your Imaan which will provide you with internal strength to overcome temptations to reverting to
old bad habits.
13. Remind yourself of Death and Hereafter often: "Remember often the terminator (or
destroyer) of all the pleasures(i.e. death)," the Messenger of Allah (peace be upon him)once
14. Resolve to continue on and follow up: Giving up bad habits or learning good habits
requires regular maintenance and determination. It is a long, ongoing process, also known as
"Tazkiyyah" in Islamic terminology. It's more difficult than the first few steps of change. ("How
many times have I dieted, for example, only to gain the weight back?"). So ensure that you follow up. Link yourself to a good Allah-fearing Islamic Scholar, make a habit of spending time in the Path of Allah and constantly engage in noble and charitable work. 15. Develop a relapse strategy: How do you ensure not to return to your bad habit you are
trying to change? Some people donate money to a good cause every time they return to sinning
or a bad habit. This reminds them of the 'cost' of going back to old bad habits. Others try
physically demanding acts to deter them from reverting to old ways. For example that if you
do___ act than you will keep three fast or pay so much sadaqah(charity) etc
16. Ask Allah for Help (Dua): MOST IMPORTANT!-Make Asking for Allah's Help an integral
part of the overall change process. Ask for Allah's Help before, during and after every attempt at
kicking a bad habit. Do so sincerely, even begging and crying, like a child does when he or she
really wants something. Allah is Ever-Willing to Help and to Respond to our needs, but it is us
who must take the first step towards Him. Allah will NEVER disappoint us! Allah Ta’ala says “
Ask me, and I will answer your call…” (Quran 40:60)
"And whosoever is conscious of Allah and keeps his duty to Him, He (Allah) will make a
way for him to get out (from) every (difficulty), and He will provide him from (sources) he
could never imagine." (Quran 65:2-3)
So surely you Can do it!!!…Just Trust and Pray to Allah and make that great change this
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