Research Profile Priv. Doz. Dr. med. Johann Bauersachs
PD Dr. med. Johann Bauersachs Medizinische Klinik I Universitätsklinikum Josef-Schneider-Str. 2 97080 Würzburg
2.) Scientific career 22.04.66
Study of medicine at the University of Freiburg
Residency at the Dept. of Internal Medicine IV (Cardiology/Nephrology), University Hospital Frankfurt
Research fellowship at the Center of Physiology, University Hospital Frankfurt (Prof. Dr. med. R. Busse)
Residency at the Dept. of Internal Medicine II (Cardiology/Angiology), University Hospital Mannheim
Residency at the Dept. of Internal Medicine, University Hospital Würzburg (Director: Prof. Dr. med. G. Ertl)
Scientific Secretary of the Special Research Program 355 of the Deutsche Forschungsgemeinschaft
Board of Internal Medicine Certification
Habilitation, Member of the Faculty, senior lecturer, Dept. of Internal Medicine, Division of Cardiology, University of Würzburg
Consultant Internal Medicine/Cardiology, University Hospital Würzburg
3.) Main scientific focus Healing and remodeling after myocardial infarction;
cardiac ischemia- and reperfusion injury;
cardiac regeneration by progenitor cells;
endothelial progenitor cells, endothelial dysfunction and platelet activation in coronary artery disease, myocardial infarction, hypertension and diabetes mellitus
4.) Membership in scientific societies Deutsche Gesellschaft für Kardiologie - Herz- und Kreislaufforschung Deutsche Gesellschaft für Innere Medizin European Society of Cardiology American Heart Association - Council on Basic Cardiovascular Sciences
5.) Awards April 2001
Oskar-Lapp-Award of the „Deutsche Gesellschaft für Kardiologie“
Albert-Fraenkel-Award of the „Deutsche Gesellschaft für Kardiologie“
6.) Reviewer/Editorial activities:
Editorial Board Member European Journal of Clinical Investigation 7.) Publications
More than 50 original articles in peer-reviewed Journals, > 20 reviews und book chapters
10 selected Publications Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R (1996) Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation94, 3341- 3347 Bauersachs J, Bouloumié A, Fraccarollo D, Hu K, Busse R, Ertl G (1999) Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial NO synthase and soluble guanylyl cyclase expression: Role of enhanced vascular superoxide anion production. Circulation100: 292-298, with Editorial Bauersachs J, Fraccarollo D, Ertl G, Gretz N, Wehling M, Christ M (2000) Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE-inhibition: mechanistic evidence to support RALES, Circulation102: 2325-2328 Bauersachs J, Galuppo P, Fraccarollo D, Christ M, Ertl G (2001) Improvement of left ventricular remodeling and function by HMG-CoA reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction. Circulation104: 982-985 Bauersachs J, Heck M, Fraccarollo D, Ertl G, Hildemann S, Wehling M, Christ M (2002) Addition of spironolactone to ACE inhibition in heart failure improves endothelial vasomotor dysfunction: Role of vascular superoxide anion formation and endothelial NO synthase expression. J Am Coll Cardiol 29: 351-358
Nahrendorf M, Hu K, Hiller KH, Galuppo P, Fraccarollo D, Schweizer G, Haase A, Ertl G, Bauer WR, Bauersachs J. Impact of HMG-CoA Reductase inhibition on Left Ventricular Remodeling after Myocardial Infarction – An experimental serial MR imaging study, J Am Coll Cardiol, 40 (2002), 1695-1700
Fraccarollo D, Galuppo P, Hildemann S, Christ M, Ertl G, Bauersachs J (2003) Additive Improvement of Left Ventricular Remodeling and Neurohormonal Activation by Aldosterone Receptor Blockade With Eplerenone and ACE Inhibition in Rats With Myocardial Infarction, J Am Coll Cardiol 42: 1666-1673, with Editorial
Schäfer A, Schulz C, Eigenthaler M, Fraccarollo D, Gawaz M, Ertl G, Walter U, Bauersachs J (2004) Novel role of fractalkine, a membrane-bound chemokine in platelet activation and adhesion. Blood103: 407-412
Frantz S, Calvillo L, Tillmanns J, Elbing I, Dienesch C, Bischoff H, Ertl G, Bauersachs J (2005) Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury. Prevention by the α-glucosidase inhibitor Acarbose. FASEB J19(6): 591-3
Thum T, Tsikas D, Stein S, Schultheiss M, Eigenthaler M, Anker SD, Poole-Wilson PA, Ertl G, Bauersachs J (2005) Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. J Am Coll Cardiol46, 1693-701, with Editorial All Publications since 2000 (without Abstracts)
Original papers Bauersachs J, Fraccarollo D, Ertl G, Gretz N, Wehling M, Christ M. Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE-inhibition: mechanistic evidence to support RALES, Circulation102 (2000), 2325-2328 Widder J, Bauersachs J, Fraccarollo D, Ertl G, Schilling L. Endothelium-dependent and - independent vasoreactivity of rat basilar artery in experimental heart failure. J Cardiovasc Pharmacol35 (2000), 515-522 Bauersachs J, Fraccarollo D, Galuppo P, Widder J, Ertl G. Endothelin receptor blockade improves endothelial vasomotor dysfunction in heart failure. Cardiovasc Res47 (2000), 142- 149 Bauersachs J, Braun C, Fraccarollo D, Widder J, Kirchengast M, Schilling L, Ertl G, Rohmeiss P. Treatment with the endothelin-A receptor antagonist LU 135252 improves renal dysfunction in rats with chronic heart failure following myocardial infarction. J Hypertens18 (2000), 1507-1514 Bauersachs J, Fleming I, Fraccarollo D, Busse R, Ertl G. Prevention of endothelial dysfunction in heart failure by vitamin E. Attenuation of vascular superoxide anion formation and increase in soluble guanylyl cyclase expression. Cardiovasc Res51 (2001), 344-350, mit Editorial Bauersachs J, Galuppo P, Fraccarollo D, Christ M, Ertl G. Improvement of left ventricular remodeling and function by HMG-CoA reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction. Circulation104 (2001), 982-985 IF: 10.517 Wagner, JA, Hu K, Bauersachs J, Wiesler M, Goparaju SK, Kunos G, Ertl G. Endogenous cannabinoids mediate hypotension in cardiogenic shock after experimental myocardial infarction. J Am Coll Cardiol38 (2001), 2048-54
Bauersachs J, Heck M, Fraccarollo D, Ertl G, Hildemann S, Wehling M, Christ M. Addition of spironolactone to ACE inhibition in heart failure improves endothelial vasomotor dysfunction: Role of vascular superoxide anion formation and endothelial NO synthase expression. J Am Coll Cardiol29 (2002), 351-358 *Fraccarollo D, *Bauersachs J, Kellner M, Galuppo P, Ertl G. Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy. Cardiovasc Res54 (2002), 85-94 (*both authors contributed equally)
Fraccarollo D, Galuppo P, Bauersachs J, Ertl G. Collagen accumulation after myocardial infarction: Effects of ETA receptor blockade and implications for early remodeling. Cardiovasc Res54 (2002), 559-567 Bauersachs J, Christ M, Ertl G, Michaelis UR, Fisslthaler B, Busse R, Fleming I. Cytochrome P450 2C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol. Cardiovasc Res54 (2002), 669-675 Christ M, Bauersachs J, Liebetrau C, Heck M, Gärtner A, Wehling M. Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H-oxidase activation: Attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. Diabetes51 (2002), 2648-2652 Bauersachs J, Fraccarollo D, Schaefer A, Ertl G. ACE-Inhibition and Endothelin-Antagonism for Endothelial Dysfunction in Heart Failure: Mono- or Combination Therapy. J Cardiovasc Pharmacol 40 (2002), 594-600 Nahrendorf M, Hu K, Hiller KH, Galuppo P, Fraccarollo D, Schweizer G, Haase A, Ertl G, Bauer WR, Bauersachs J. Impact of HMG-CoA Reductase inhibition on Left Ventricular Remodeling after Myocardial Infarction – An experimental serial MR imaging study, J Am Coll Cardiol, 40 (2002), 1695-1700 Strotmann J, Bauersachs J, Fraccarollo D, Kirchengast M, Schnabel PA, Sykora J, Ertl G, Voelker W. The trauma of non-traumatic coronary devices and its impact on vascular reactivity and morphology. Am J Physiol Heart Circ Physiol283 (2002), H2356-H2362 Schäfer A, Burkhardt M, Vollkommer T, Bauersachs J, Münzel T, Walter U, Smolenski A. Endothelium-dependent and –independent relaxation and VASP serines 157/239 phosphorylation by cyclic nucleotide-elevating vasodilators in rat aorta, Biochem Pharmacol 65 (2003), 397-405 Frantz S, Fraccarollo D, Wagner H, Behr TM, Jung P, Angermann CE, Ertl G, Bauersachs J. Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure. Cardiovasc Res 57 (2003), 749-756 Wagner JA, Hu K, Karcher J, Bauersachs J, Schafer A, Laser M, Han H, Ertl G. CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction. Br J Pharmacol 7 (2003), 1251-8 Han H, Kaiser R, Hu K, Laser M, Ertl G, Bauersachs J. Selective Modulation of Endogenous Nitric Oxide Formation in Ischemia/Reperfusion Injury in Isolated Rat Hearts: Effects on Regional Myocardial Flow and Enzyme Release. Basis Res Cardiol98 (2003), 1-10 Schäfer A, Fraccarollo D, Hildemann S, Tas P, Ertl G, Bauersachs J. Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction. Cardiovasc Res58 (2003), 655-662 Schäfer A, Fraccarollo D, Hildemann S, Christ M, Eigenthaler M, Kobsar A, Walter U, Bauersachs J. Inhibition of platelet activation in congestive heart failure by selective aldosterone receptor antagonism and ACE inhibition, Thrombosis Haemostasis89 (2003), 1024-1030 Schanzenbächer P, Bauersachs J. Acquired right coronary artery fistula draining to the right ventricle. Angiographic documentation of first appearance following reperfusion for acute myocardial infarction, with subsequent spontaneous closure. Heart89 (2003), e22
Fraccarollo D, Galuppo P, Hildemann S, Christ M, Ertl G, Bauersachs J. Additive Improvement of Left Ventricular Remodeling and Neurohormonal Activation by Aldosterone Receptor Blockade With Eplerenone and ACE Inhibition in Rats With Myocardial Infarction, J Am Coll Cardiol42 (2003), 1666-1673
Widder J, Pelzer T, von Poser-Klein C, Hu K, Jazbutyte V, Fritzemeier, KH, Hegele-Hartung C, Neyses L, Bauersachs J. Improvement of endothelial dysfunction by selective estrogen receptor-α stimulation in ovariectomized spontaneously hypertensive rats. Hypertension42 (2003), 991-996
Frantz S, Hu K, Widder J, Bayer B, Witzel CC, Schmidt I, Galuppo P, Strotmann J, Ertl G, Bauersachs J. Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarction. Br J Pharmacol141 (2004), 9-14 mit Editorial Schäfer A, Schulz C, Eigenthaler M, Fraccarollo D, Gawaz M, Ertl G, Walter U, Bauersachs J. Novel role of fractalkine, a membrane-bound chemokine in platelet activation and adhesion. Blood (2004) 103, 407-412 Schäfer A, Fraccarollo D, Tas P, Schmidt I, Ertl G, Bauersachs J. Endothelial dysfunction in congestive heart failure: ACE inhibition versus angiotensin II antagonism. Eur J Heart Fail6 (2004), 151-159 Schäfer A, Wiesmann F, Neubauer S, Eigenthaler M, Bauersachs, J, Channon KM. Rapid regulation of platelet activation in vivo by nitric oxide. Circulation 109 (2004), 1819-1822
Schäfer A, Widder J, Eigenthaler M, Ertl G, Bauersachs J. Reduced nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats. Biochem Pharmacol67 (2004), 2273-2279 Widder J, Behr TM, Fraccarollo D, Hu K, Galuppo P, Angermann CE, Ertl G, Bauersachs J. Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent. Cardiovasc Res63 (2004), 161-167 Schäfer A, Widder J, Eigenthaler M, Bischoff H, Ertl G, Bauersachs J. Increased platelet activation in young Zucker-rats with impaired glucose tolerance is improved by acarbose. Thromb Haemost92 (2004), 97-103 Schafer A, Alp NJ, Cai S, Lygate CA, Neubauer S, Eigenthaler M, Bauersachs J, Channon KM Reduced Vascular NO Bioavailability in Diabetes Increases Platelet Activation In Vivo. Arterioscl Thromb Vasc Biol24 (2004), 1720-26 IF
Frantz S, Störk S, Ok S, Angermann CE, Ertl G, Bauersachs J. Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytes. Am J Cardiol 94 (2004), 671-3 Obergfell A, Strotmann J, Bonz A, Bauersachs J, Ertl G, Walter U, Grossmann R. Impaired platelet responses to clopidogrel and ticlopidine in a patient with recurrent coronary stent stenosis. Thromb Haemost.92 (2004),1446-7 Frantz S, Calvillo L, Tillmanns J, Elbing I, Dienesch C, Bischoff H, Ertl G, Bauersachs J. Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury. Prevention by the α-glucosidase inhibitor Acarbose. FASEB J (2005), 19(6): 591-3. Epub 2005 Jan 25
Schäfer A, Fraccarollo D, Eigenthaler M, Tas P, Firnschild A, Frantz S, Ertl G, Bauersachs J: Rosuvastatin reduces platelet activation in heart failure: Role of nitric oxide bioavailability. Arterscler Thromb Vasc Biol 25 (2005), 1071-7 Fraccarollo D, Galuppo P, Isabel Schmidt, Ertl G, Bauersachs J. Amelioration of left ventricular remodeling by combined aldosterone and angiotensin receptor blockade after myocardial infarction, Cardiovasc Res 67 (2005), 97-105 Thum T, Tsikas D, Stein S, Schultheiss M, Eigenthaler M, Anker SD, Poole-Wilson PA, Ertl G, Bauersachs J. Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. J Am Coll Cardiol 46 (2005), 1693-701 Frantz S, Brandes RP, Hu K, Rammelt K, Wolf J, Scheuermann H, Ertl G, Bauersachs J. Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91phox (2005) Basic Res Cardiol, in press Reviews / Letters / Book Chapters
Bauersachs J. Das Herz- normale Funktion und wichtige Erkrankungen. In: Kempf HD, Preuss P (Hrg.) Praxisbuch Herzgruppe. Thieme Verlag, Stuttgart (2000) Bauersachs J. Das Kreislaufsystem. In: Kempf HD, Preuss P (Hrg.) Praxisbuch Herzgruppe. Thieme Verlag, Stuttgart (2000) Bauersachs J. Herzpatient und Sexualität. In: Kempf HD, Preuss P (Hrg.) Praxisbuch Herzgruppe. Thieme Verlag, Stuttgart (2000) Bauersachs J, Christ M, Ertl G, Fisslthaler B, Busse R, Fleming I. Cortisol increases EDHF- mediated relaxations in porcine coronary arteries and up-regulates the expression of cytochrome P450 2C9, In: P. M. Vanhoutte (ed.): EDHF 2000 (2001), London, Taylor & Francis, 173-179 Bauersachs J, Christ M. Natriuresis by low-dose spironolactone and ACE inhibition in heart failure. MDConsult-Cardiology on-line publication (2001) Schäfer A, Bauersachs J. High altitude pulmonary edema: Potential protection by red wine. Nutr Metab Cardiovasc Dis12 (2002), 306-10 Bauersachs J, Fraccarollo D. Aldosterone antagonism in addition to angiotensin-converting enzyme inhibitors in heart failure. Minerva Cardioangiologica 51 (2003), 155-164 Bauersachs J, Schäfer A. Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches. Current Vascular Pharmacology2 (2004), 115-124 Ertl G, Bauersachs J. Endothelin Receptor Antagonists in Heart Failure: Current Status and Future Directions. Drugs64 (2004), 1029-1040 Fraccarollo D, Galuppo P, Bauersachs J. Mineralcorticoid Receptor Antagonism and Cardiac Remodeling in Ischemic Heart Failure. Curr Med Chem Cardiovasc Hematol Agents (2004), 287-94.
Schäfer A, Eigenthaler M, Bauersachs J. Platelet activation in heart failure. Clin Lab50 (2004), 559-566 Bauersachs J, Schäfer A. Heart Failure, Platelet Activation and Inhibition of the Renin- Angiotensin-Aldosterone System. Arch Malad Coeur Vaiss97 (2004), 889-893
Bauersachs J. Nitric oxide and superoxide in cardiac physiology and pathophysiology.
Bauersachs J. Aldosterone antagonism in heart failure: Improvement of cardiac remodelling, endothelial dysfunction, and platelet activation. Eur J Clin Invest34 (2004), 649-652 Frantz S, Bauersachs J, Kelly R. Innate Immunity and the heart. Curr Pharmacyt Design11 (2005), 1279-1290 Bauersachs J, Schäfer A. Tetrahydrobiopterin and eNOS dimer:monomer ratio – a clue to eNOS uncoupling in diabetes? Cardiovasc Res65 (2005), 768-769 Bauersachs J. Pharmakologie der Aldosteroninhibition. In: Dietz R, Philipp S, Willenbrock R: Inhibition des Aldosterons: Neue Aspekte (2005) UNI-MED Verlag Bremen, 51-58 Bauersachs J, Ertl G. Kardiales Remodeling. In: Ganten D, Ruckpaul K: Molekulare Medizin – Endokrinopathien 2. Springer Verlag 2005, in press Thum T, Bauersachs J. Endothelial progenitor cells as potential drug targets. Current Drug Targets - Cardiovascular and Haematological Disorders 5 (2005), 277-286 Bauersachs J, Thum T, Frantz S, Ertl G. Cardiac regeneration by progenitor cells - bedside before bench? Eur J Clin Invest 35 (2005), 417-420 Thum T, Bauersachs J. Growth hormone regulates vascular function-what we know from bench and bedside. Eur J Clin Pharmacol (2005), 1-4 Thum T & Bauersachs J. Mobilisation of bone marrow derived stem cells after myocardial infarction and left ventricular function – Simply effects of optimized drug treatment? Eur Heart J (2005), in press Thum T, Bauersachs J. ADMA, endothelial progenitor cells, and cardiovascular risk. Circ Res 97 (2005), e84 Thum T, Bauersachs J, Poole-Wilson PA, Volk HD, Anker SD. The dying stem cell hypothesis -Immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. J Am Coll Cardiol (2005), in press
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