10_TTManual_2008/09_Master_Sect_9:Layout 1 9/8/08 10:20 AM Page 9.28 11 Ethylenediamine Dihydrochloride – Patient Information
Your T.R.U.E. TEST results indicate that you have a contact allergy to ethylenediamine. Ethylenediamine (EDD)in contact with your skin may result in dermatitis.This contact allergy may cause your skin to react when it isexposed to this substance, although it may take several days for the symptoms to appear. Typical symptomsinclude redness, swelling, itching and fluid-filled blisters.
Ethylenediamine is a substance that is used to manufacture various drugs and industrial compounds. EDD is acolorless liquid that is used as a preservative, emulsifier and stabilizer in certain medical creams, cosmetics and avariety of other products.
Where is ethylenediamine found?
At work, you may find ethylenediamine used in the manufacture of:
• Fuel additives and corrosion inhibitors • Surfactants, emulsifers and dispersants At home, you probably won’t find ethylenediamine - even though it has been used as a
starting material to produce many drugs, laundry additives, fungicides, and cured epoxy
Some antihistamines used in the treatment of asthma, hay fever, motion sickness andhives may cross react with EDD. You may have a general skin reaction to theseantihistamine drugs as well as to aminophylline drugs used for asthma which maycontain EDD as an impurity.
Rarely, a few individuals with ethylenediamine allergies may develop skin reactions tosome piperazine-related drugs, including some antihistamines. Talk to your doctor if youhave any reactions to these medications.
You may be exposed to EDD through industrial products such as solvents, textile resins,inhibitors, antifreezers, epoxy hardeners and coolant oils.
Water-based industrial products may contain EDD as a fungicide. EDD is also acomponent of some dyes, insecticides and synthetic waxes.
10_TTManual_2008/09_Master_Sect_9:Layout 1 9/8/08 10:20 AM Page 9.29 Ethylenediamine Dihydrochloride
How can you avoid ethylenediamine?
• Avoid direct skin contact with chelators and the substances used to manufacture carbamates, epoxy resin curing agents, fuel additives, and the other industrial products listed above.
• Do not use products that list ethylenediamine or related chemicals on the label, ingredients list or Material Safety Data Sheet (MSDS). If there is no information and you have questions, contact the productmanufacturer.
• Tell your physician, pharmacist, dentist and veterinarian that you are allergic to ethylenediamine.
Ask for preparations that do not contain ethylenediamine or related substances.
• Wear protective gloves. Heavy-duty gloves made of natural or synthetic rubber, or vinyl,may be good for working with many potential sources of ethylenediamine.
• If you think that you contact ethylenediamine at work, ask your employer for MSDS or manufacturer information on the product(s). Talk to your employer about using a different product or wearing protectivegloves and clothing.
What should you look for and avoid?*
Avoid products that list any of the following names in the ingredients, MSDS or package insert: • Ethylenediamine dihydrochloride or 1,2-ethanediamine, dihydrochloride; chlorethamine;
dimethylenediamine dihydrochloride; ethylenediammonium chloride; 1,2-diaminoethane dihydrochloride Ethylenediamine dihydrochloride -related substances that you may also react to: Related substances to which you may react: *For additional information about ethylenediamine visit the United States National Library of Medicine online at The lists above are brief.
They are not comprehensive. Product formulations also change frequently. Read product labels carefully and talk to your doctor if you have questions.
These are general guidelines. Talk to your doctor for more specific instructions.
For further information about contact allergies and patch testing, visit
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