Studiens namn

O rganization to
S trategies in Acute
I schemic
S yndromes
Overall Efficacy of Fondaparinux vs Enoxaparin in VTE Prevention:

Fondaparinux better
Enoxaparin better
P = 0.000000000000000001
% odds reduction
Overall odds reduction for proximal DVT = 57.4% [CI: 72.3 - 35.6]; p = 10-6 Turpie et. al. Arch Intern Med 2002: 162: 1833-40 Baseline Characteristics
Fonda (%)
Therapies During Initial Hospitalization
Fonda (%)
70% of patients recruited from centers with cath labs.
2 of 3: Age>60, ST Δ, positive cardiac markers opidogrel, IV GP II
Clopidogrel, IV GP b/IIIa
IIb/IIIa as per local practice
1 mg/kg BID
Primary: Efficacy: Death, MI, refractory ischemia 9 day
Safety: Major bleeds
Risk benefit: Death, MI, refractory ischemia, major bleeds
Secondary: Above & each component (especially deaths) at 30 & 180 d
Hypothesis: First test non-inferiority, then test superiority
Major Bleeding: 9 Days
95% CI 0.45-0.62
ive Hazard
Fondaparinux is “non-inferior” compared with enoxaparin at 9 days, with substantially lower rates of important bleeds. The net benefit-risk balance clearly Bleeding increases the risk of death significantly. At one month and at 6 months there is a significant reduction in mortality with

Strokes are also significantly reduced by fondaparinux, so that there is a clear Consistent results are observed in those undergoing PCI (including early PCI) and Clinical Implications :Results
Treating 1000 ACS patients with fondaparinux instead of enoxaparin prevents: - 10 deaths or MI- 4 strokes- 25 major bleeds THE OASIS 5 TRIAL CLEARLY DEMONSTRATES THAT FONDAPARINUX IS THE PREFERRED ANTICOAGULANT FOR TREATMENT OF ACS.


Information Update 11/12/13 NorthAble receives information from our many networks which we disseminate through this Update. Feel free to share this or to contact us for further information on anything mentioned - or use the details below to contact directly. Events – Seminars – Courses – Meetings Growing up with Autism Course (Whangarei). Starts 11 Feb 2014. Co

Whs observational 9 (18916 - activated, traditional)

HEALTH STUDY PLEASE USE A BALL-POINT PEN WHEN COMPLETING THIS QUESTIONNAIRE. IT IMPROVES THE QUALITY OF OUR DATA. 1. Birth date: Last 6 digits of SSN: (optional) 2. WITHIN THE PAST 2 YEARS, have you been NEWLY DIAGNOSED with any of the following illnesses or had any of the following procedures? Please answer NO or YES on each line. IF YES, indicate the date (month/year) of the d

© 2010-2014 Pdf Medical Search