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Studiens namn

O rganization to
S trategies in Acute
I schemic
S yndromes
Overall Efficacy of Fondaparinux vs Enoxaparin in VTE Prevention:

Fondaparinux better
Enoxaparin better
P = 0.000000000000000001
% odds reduction
Overall odds reduction for proximal DVT = 57.4% [CI: 72.3 - 35.6]; p = 10-6 Turpie et. al. Arch Intern Med 2002: 162: 1833-40 Baseline Characteristics
Fonda (%)
Therapies During Initial Hospitalization
Fonda (%)
70% of patients recruited from centers with cath labs.
2 of 3: Age>60, ST Δ, positive cardiac markers opidogrel, IV GP II
Clopidogrel, IV GP b/IIIa
IIb/IIIa as per local practice
1 mg/kg BID
Primary: Efficacy: Death, MI, refractory ischemia 9 day
Safety: Major bleeds
Risk benefit: Death, MI, refractory ischemia, major bleeds
Secondary: Above & each component (especially deaths) at 30 & 180 d
Hypothesis: First test non-inferiority, then test superiority
Major Bleeding: 9 Days
95% CI 0.45-0.62
ive Hazard
Fondaparinux is “non-inferior” compared with enoxaparin at 9 days, with substantially lower rates of important bleeds. The net benefit-risk balance clearly Bleeding increases the risk of death significantly. At one month and at 6 months there is a significant reduction in mortality with

Strokes are also significantly reduced by fondaparinux, so that there is a clear Consistent results are observed in those undergoing PCI (including early PCI) and Clinical Implications :Results
Treating 1000 ACS patients with fondaparinux instead of enoxaparin prevents: - 10 deaths or MI- 4 strokes- 25 major bleeds THE OASIS 5 TRIAL CLEARLY DEMONSTRATES THAT FONDAPARINUX IS THE PREFERRED ANTICOAGULANT FOR TREATMENT OF ACS.


Information Update 11/12/13 NorthAble receives information from our many networks which we disseminate through this Update. Feel free to share this or to contact us for further information on anything mentioned - or use the details below to contact directly. Events – Seminars – Courses – Meetings Growing up with Autism Course (Whangarei). Starts 11 Feb 2014. Co

Whs observational 9 (18916 - activated, traditional)

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