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CURRICULUM VITAE

DATOS PERSONALES
NOMBRE: LUIS FRANCISCO HERNANDEZ RODRIGUEZ.
FECHA DE NACIMIENTO: 5 DE FEBRERO DE 1942.
LUGAR DE NACIMIENTO: CARACAS - VENEZUELA.
ESTUDIOS REALIZADOS
Bachiller en Ciencias 1959. Liceo Andrés Bello - Caracas-Venezuela. Primero en la
Promoción.
Médico Cirujano. 1966. Universidad de los Andes (U.L.A.) - Mérida-Venezuela.
Primero en la Promoción.
AREAs DE INVESTIGACION DE MAYOR INTERES: NEUROFISIOLOGIA,
NEUROQUIMICA Y ELECTROFORESIS CAPILAR.

PREMIOS Y DISTINCIONES OBTENIDAS:

- PREMIO NACIONAL A LA INNOVACION TECNOLOGICA 1993 - ORDEN ANDRES BELLO EN 2DA. CLASE, 1993. - MIEMBRO DE NUMERO DE LA ACADEMIA DE MERIDA. - INVESTIGADOR DEL NIVEL IV SEGUN LA CLASIFICACION DEL PLAN DE PROMOCION DEL INVESTIGADOR (PPI). - PREMIO “LORENZO MENDOZA FLEURY” OTORGADO POR LA - ORDEN “DON TULIO FEBRES CORDERO” OTORGADA POR LA - ORDEN “DON TULIO FEBRES CORDERO” OTORGADA POR LA ASAMBLEA LEGISLATIVA DE MERIDA AL MEJOR GRUPO DE INVESTIGACION DE LA UNIVERSIDAD DE LOS ANDES. OCTUBRE 1996. - PREMIO NACIONAL DE CIENCIAS MENCION INNOVACION TECNOLOGICA OTORGADO POR EL CONICIT, Diciembre de 1998. - MIEMBRO DE LA ACADEMIA DE CIENCIAS DE AMÉRICA - PROFESOR TITULAR DE LA CATEDRA HONORARIA SANTIAGO RAMON Y CAJAL DE LA FACULTAD DE MEDICINA DE LA UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO, 2003 - MEDALLA DE HONOR CONCEDIDA POR EL INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS (IVIC), 2004.
CONTRIBUCIONES A CONGRESOS INTERNACIONALES
Presentación de más de 119 trabajos. Chairman en varios de ellos.
REVISTAS Y CONGRESOS:
Miembro del Board Internacional de editores de la revista JOURNAL OF Miembro del Board Internacional de editores de la Conferencia IN VIVO
SOCIEDADES A LAS QUE PERTENECE:

Sociedad Venezolana de Ciencias Fisiológicas. Venezuela. Neuroscience Society. Estados Unidos de América. British Brain Research Association. Inglaterra. International Brain Research Organization. World. Federation of Neuroscientists. Estados Unidos de América. American Association for the Advancement of Science.
CARGOS UNIVERSITARIOS DESEMPEÑADOS:
Preparador,
Preparador, Departamento de Bioquímica, U.L.A., 1964. Instructor en Fisiología, Departamento de Fisiología, U.L.A., 1967. Profesor Asistente de Fisiología, Departamento de Fisiología, U.L.A., 1970. Profesor Agregado de Fisiología, Departamento de Fisiología, U.L.A., 1974. Visiting Fellow, Princeton University, NJ., U.S.A., 1975. Research Associate. Neuroscience Program. Princeton University, NJ. U.S.A., 1976 a 1979. Profesor Asociado de Fisiología, Departamento de Fisiología, U.L.A., 1983. Coordinador General del Consejo de Desarrollo Científico, Humanístico y Tecnológico (C.D.C.H.T.), U.L.A., 1980 a 1984. Visiting Senior Scientist. Neuroscience Program. Princeton University,NJ., U.S.A., 1986 a 1988. Profesor Titular de Fisiología, Departamento de Fisiología, U.L.A., desde el 15 de Noviembre de1988. ACTIVIDADES SOCIALES:
Presidente del Centro de Estudiantes de Medicina: 1964 Presidente de la Federación de Centros Universitarios: 1965 Vicepresidente del Colegio de Médicos: 1969
PATENTES:

2.) CAPILAR CON DISPOSITIVO OPTICO INCORPORADO PARA 3.) PROCEDIMIENTO ANALITICO PARA ELECTROFORESIS CAPILAR CON DETECCION MEDIANTE FLUORESCENCIA INDUCIDA POR LASER:
ARTICULOS PUBLICADOS:
1.
BRIESE, E. and HERNANDEZ. L. Self-stimulation Enhancement in
Diabetic Rats. Acta Physiologica Latinoamericana, XX: 24-29, 1970.
BRIESE, E. and HERNANDEZ, L. Hypothalamic Mechanism of Diabetic
Hyperphagia.Acta Physiologica Latinoamericana, XXI (Suppl. 1): 31, 1970.
BRIESE, E., RONDON MORALES, R. and HERNANDEZ, L. Glucostatic
Modulation of the Hypothalamus by Phenformin. Physiology and Behavior , 7
(6): 807-810, 1971.
HERNANDEZ, L. and BRIESE, E. Insulin Inhibition of Hypothalamic Self-
stimulation. Acta Physiologica Latinoamericana, XXI: 57-63, 1971.
HERNANDEZ, L. and BRIESE, E. Analysis of Diabetic Hyperphagia and
Polydipsia. Physiology and Behavior, 9 (5): 741-746, 1972.
6. HOEBEL, BG., HERNANDEZ, L. and THOMPSON, RD.
Phenylpropanolamine Inhibits Feeding, but not Drinking, Induced by
Hypothalamic Stimulation. J. Comp. Physiol. Psychol. 89 (9): 1046-1052,
1975.
RESNICK, SI., HERNANDEZ, L., CHEN, J. and HOEBEL, B.G. Effect of
the Anorectic Drug, Phenylpropanolamine, on Blood Glucose in Rats.
Pharmacology, 17: 157-162, 1978.
8. HERNANDEZ, LUIS. Optic discriminator for Single Cell Activity. Physiology
and Behavior, 25(4): 607-610, 1980.
HERNANDEZ, L. and GOTTBERG, E. Systemic Insulin decreases Lateral
Hypothalamic Unit Activity. Physiology and Behavior, 25(6): 981-984, 1980.
HOEBEL, BG., HERNANDEZ, L., MONACO, A.P. and MILLER, W.C.
Amphetamine-induced Overeating and Overweight in Rats.Life Sciences,
28(1): 77-82, 1981.
11. HERNANDEZ, L. and HOEBEL, B.G. Overeating after Midbrain 6-
Hydroxydopamine: Prevention by Central Injection of Selective Catecholamine
Reuptake Blockers. Brain Research, 245: 333-343, 1982.
HERNANDEZ, L., PAEZ, X. and HAMLIN, C. Neurotransmitters Extraction
by Local Intracerebral Dialysis in Anesthetized Rats. Pharmacology
Biochemistry and Behavior, 8(2): 159-162, 1983.
HERNANDEZ, L., PARADA, M. and HOEBEL, B.G. Amphetamine-
Induced Hyperphagia and Obesity caused by Intraventricular or Lateral
Hypothalamic Injections in Rats. J. Pharmacol. & Exper. Ther. 227: 524-530,
1983.
HOEBEL, BG., MONACO, A.P., HERNANDEZ, L., AULISI, E.F.,
STANLEY, B.G. and LENARD, L. Self-injection of Amphetamine directly
into the Brain. Psychopharmacology, 81: 158-163, 1983.
15. AHLSKOG, JE., RANDALL, P.K., HERNANDEZ, L. and HOEBEL, B.G.
Diminished Amphetamine Anorexia and Enhanced Fenfluramine Anorexia after
Midbrain 6-Hydroxydopamine. Psychopharmacology, 82: 118-121, 1984.
HERNANDEZ, L., VALDERRAMA, A. and LISCANO, E. Efectos de la
dieta sobre la reproducción de dos especies de triatominos: Rhodnius Prolixus y
Triatoma Maculata. Revista Brasileira do Biologia. 1985.
BAPTISTA, T., PARADA, M. and HERNANDEZ, L. Pharmacological
evidence that dopaminergic satiety systems function with D2 type receptors.
Appetite, 7: 240, 1986.
HERNANDEZ, L., STANLEY, B.G. and HOEBEL, B.G. A small,
removable microdialysis probe.
Life Sciences, 39: 2629-2637, 1986.
19. MURZI, E., HERNANDEZ, L. and BAPTISTA, T. Lateral hypothalamic
sites eliciting eating affect medullary taste neurons in rats. Physiology and
Behavior, 36 (5): 829-834, 1986.
BAPTISTA, T., PARADA, M. and HERNANDEZ, L. Long term
administration of some antipsychotic drugs increases body weight and feeding
in rats: Are D2 Dopamine receptors involved? Pharmacology Biochemistry
and Behavior, 27(3): 399-405, 1987.
HERNANDEZ, L., LEE, F. and HOEBEL, B.G. Simultaneous microdialysis
and amphetamine infusion in the Nucleus Accumbens and Striatum of freely
moving rats: Increase in extracellular dopamine and serotonin. Brain Res. Bull.
19(6): 623-628, 1987.
HERNANDEZ, L., AUERBACH, S. and HOEBEL, B.G. Phencyclidine
(PCP) injected in the Nucleus Accumbens increases extracellular dopamine and
serotonin as measured by microdialysis. Life Sciences , 42(18): 1713-1723,
1988.
HERNANDEZ, L. and HOEBEL, B.G. Food reward and cocaine increase
extracellular dopamine in the Nucleus Accumbens as measured by
microdialysis. Life Sciences, 42 (18): 1705-1712, 1988.
HERNANDEZ, L. and HOEBEL, B.G. Feeding and hypothalamic
stimulation increase dopamine turnover in the Accumbens. Physiol. &
Behav. 44 (4/5): 599-606, 1988.
HERNANDEZ, L. and HOEBEL, B.G. Monoamine increase by cocaine
and procaine in the nucleus accumbens: A microdialysis study. Soc.
Neurosci. Abstr. 14: 658, 1988.
HOEBEL, B.G., HERNANDEZ, L., MC CLELLAND, R.C. and
SCHWARTZ, D. Dexfenfluramine and Feeding reward. Clinical
Neuropharmacology, 11 (Suppl. I): S72-S83, 1988.
PARADA, M.A., HERNANDEZ, L. and HOEBEL, B.G. Sulpiride injections
in the lateral hypothalamus induce feeding and drinking in rats. Pharmacology
Biochemistry and Behavior, 30(4): 917-923, 1988.
PARADA, M.A., HERNANDEZ, L. and SANTIAGO, C. An improved
circular tilt-cage shows that intrahypothalamic injections of sulpiride increase
locomotion. Brain Research Bulletin, 21(6): 873-880, 1988.
PARADA, M.A., HERNANDEZ, L., SCHWARTZ, D. and HOEBEL, B.G.
Hypothalamic infusion of amphetamine increases serotonin, dopamine, and
norepinephrine. Physiology and Behavior, 44(4/5): 607-610, 1988.
30. ADVIS, J.P., HERNANDEZ, L. and GUZMAN, N.A. Analysis of brain
neuropeptides by capillary electrophoresis: determination of luteinizing
hormone-releasing hormone from ovine hypothalamus. Peptide Research,
2(6): 389-394, 1989.
GUZMAN, NA., HERNANDEZ, L. and ADVIS, J.P. Effect of low
temperature storage (on collected urine specimens) in the identification and
quantitation of urinary metabolites by capillary electrophoresis. Journal of
Liquid Chromatography, 12(13): 2563-2574, 1989.
GUZMAN, N.A., HERNANDEZ, L. and HOEBEL, B.G. Capillary
electrophoresis: A new era in microseparations. Biopharm. 2: 22-37, 1989.
HERNANDEZ, L. and HOEBEL, B.G.Haloperidol given chronically
decreases basal dopamine in the prefrontal cortex more than the striatum or
nucleus accumbens as simultaneously measured by microdialysis. Brain
Research Bulletin, 22 (4): 763-769, 1989.
HERNANDEZ, L. and HOEBEL, B.G. Food intake and lateral
self- stimulation covary after medial hypothalamic lesions 6-hydroxydopamine injections that cause obesity. Behavioral Neurosciences,
HOEBEL, B.G. and HERNANDEZ, L. Microdialysis studies of
Psicostimulants.
NIDA Monographs. 1989.
MC CLELLAND, R.C., SARFATY, T., HERNANDEZ, L. and HOEBEL,
B.G. The appetite suppressant, d-fenfluramine, decreases self-stimulation at a
feeding site in the lateral hypothalamus. Pharmacology, Biochemistry and
Behavior, 32(2): 411-414, 1989.
MIFSUD, J.C., HERNANDEZ, L. and HOEBEL, B.G. Nicotine infused into
the nucleus accumbens increases synaptic dopamine as measured by in vivo
microdialysis. Brain Research, 478: 365-367, 1989.
PARADA, MA., HERNANDEZ, L. and HOEBEL, B.G. Is dopamine in the
lateral hypothalamus involved in the inhibitory regulation of exploratory
behavior related to food and water seeking? Appetite, 12: 229-230, 1989.
PARADA, M. A., HERNANDEZ, L., PAEZ, X., BAPTISTA, T., PUIG
DE PARADA, M. and QUIJADA, M.G.Mechanism of the body weight
increase induced by systemic sulpiride. Pharmacology, Biochemistry and
Behavior, 33(1): 45-50, 1989.
SCHWARTZ, D., HERNANDEZ, L. and HOEBEL, B.G. Fenfluramine
administered systemically or locally increases extracellular serotonin in the
lateral hypothalamus as measured by microdialysis. Brain Research, 482: 261-
270, 1989.
SCHWARTZ, D., MCCLANE, S., HERNANDEZ, L. and HOEBEL, B.G.
Feeding increases extracellular serotonin in the lateral hypothalamus of the rat
as measured by microdialysis. Brain Research, 479: 349-354, 1989.
SILVA, E. and HERNANDEZ, L. Goldthioglucose causes brain
norepinephrine and serotonin depletion correlated with increased body weight.
Brain Research, 490: 192-195, 1989.
STANLEY, BG., SCHWARTZ, D.H., HERNANDEZ, L., HOEBEL, B.G.
and LEIBOWITZ, S.F. Patterns of extracellular norepinephrine in the
paraventricular hypothalamus: Relationship to circadian rhythm and
deprivation-induced eating behavior. Life Sci. 45: 275-282, 1989.
STANLEY, BG., SCHWARTZ, D.H., HERNANDEZ, L., LEIBOWITZ
S.F. and HOEBEL, B.G. Patterns of extracellular 5-hydroxyindoleacetic acid
(5-HIAA) in the paraventricular hypothalamus (PVN): Relationship to circadian
rhythm and deprivation-induced eating behavior. Pharmacology, Biochemistry
and Behavior, 33(1): 257-260, 1989.
BAPTISTA, T., HERNANDEZ, L., BURGUERA, J.L., BURGUERA, M.
and HOEBEL, B.G. Chronic lithium administration enhances serotonin release
in the lateral hypothalamus but not in the hippocampus in rats. A microdialysis
study. Journal of Neural Transmission, 82(1): 31-41, 1990.
BAPTISTA, T., HERNANDEZ, L. and HOEBEL, B.G. Systemic sulpiride
increases dopamine metabolites in the lateral hypothalamus. Pharmacol.
Biochem. & Behav. 37(2): 227-229, 1990.
BRIESE, E., RADA, P. and HERNANDEZ, L. Electrical hypothalamic
stimulation in rats induces hyperthermia if and only if they learn to self-
stimulate. Physiology & Behavior, 47(4): 635-639, 1990.
GUZMAN, NA., BERCK, C.M., HERNANDEZ, L. and ADVIS, J.P.
Capillary Electrophoresis as a Diagnostic Tool-Determination of Biological
Constituents Present in Urine of Normal and Pathological Individuals. Journal
of Liquid Chromatography, 13(19): 3833-3848, 1990.
HERNANDEZ, L., BAPTISTA, T. and HOEBEL, B.G. Neurochemical
effects of chronic haloperidol and lithium assessed by brain microdialysis in
rats. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 14(Suppl): S17-S35,
1990.
HERNANDEZ, L. and HOEBEL, B.G. Feeding enhances dopamine turnover
in the prefrontal cortex. Brain Res. Bull. 25(6): 975-979, 1990.
HERNANDEZ, L. et JOSHI, N. L'electrophorese capillaire et la détection en
fluorescence induite par laser. Spectra 2000 No. 153, pp. 40-43, 1990.
HERNANDEZ, L., MARQUINA, R., ESCALONA, J. and GUZMAN, N.
Detection and quantification of capillary electrophoresis zones by fluorescence
microscopy. J. Chromatogr. 502: 247-255, 1990.
PARADA, M. A., HERNANDEZ, L., PUIG DE PARADA, M., PAEZ, X.
and HOEBEL, B.G. Dopamine in the lateral hypothalamus may be involved in
the inhibition of locomotion related to food and water seeking. Brain Research
Bulletin, 25 (6): 961-968, 1990.
RADA, P. and HERNANDEZ, L. Opposite changes of dopamine turnover in
prefrontal cortex and nucleus accumbens after amygdaloid kindling. Neurosci.
Letters, 117: 144-148, 1990.
SCHWARTZ, D.H., HERNANDEZ, L. and HOEBEL, B.G. Serotonin
release in lateral and medial hypothalamus during feeding and its anticipation.
Brain Res. Bull. 25(6): 797-802, 1990.
SCHWARTZ, David H., HERNANDEZ, L. and HOEBEL, B.G. Tryptophan
increases extracellular serotonin in the lateral hypothalamus of food-deprived
rats. Brain Research Bulletin, 25 (6): 803-807, 1990.
BAPTISTA, T., MURZI, E., HERNANDEZ, L., BURGUERA, J.L. and
BURGUERA, M. Mechanism of the sex-dependent effect of lithium on body
weight in rats. Pharmacology Biochemistry and Behav. 38 (3): 533-537,
1991.
HERNANDEZ, L., ESCALONA, J., JOSHI, N. and GUZMAN, N. Laser-
induced fluorescence and fluorescence microscopy for capillary electrophoresis
zone detection. J. Chromatogr. 559: 183-196, 1991.
HERNANDEZ, L., GUZMAN, N.A. and HOEBEL, B.G. Bidirectional
microdialysis in vivo shows differential dopaminergic potency of cocaine,
procaine and lidocaine in the nucleus accumbens using capillary
electrophoresis for calibration of drug outward diffusion. Psychopharmacology,
105: 264-268, 1991.
HERNANDEZ, L., PARADA, M., BAPTISTA, T., SCHWARTZ, D.,
WEST, H.L, MARK, G.P., and HOEBEL, B.G. Hypothalamic serotonin in
treatments for feeding disorders and depression as studied by brain
microdialysis. J. Clin. Psychiatry, 53: 1 (Suppl. 12), 32-40, 1991.
MURZI, E., BAPTISTA, T. and HERNANDEZ, L.Hypothalamic sites
affecting masticatory neurons in rats. Brain Research Bulletin, 26 (3): 321-
325, 1991.
PARADA, M.A., PUIG DE PARADA, M., HERNANDEZ, L. and MURZI,
E. Ventromedial hypothalamus vs. lateral hypothalamic D2 satiety receptors in
the body weight increase induced by systemic sulpiride. Physiology and
Behavior, 50 (6): 1161-1165, 1991.
BURGUERA, J.L., BURGUERA, M., HERNANDEZ, L., DE LA
GUARDIA, M. and SALVADOR, A. Flow injection analysis with front-
surface illumination laser induced fluorescence spectrometry for analytical
applications. J. Flow Injection Anal., 9 (1): 39-46, 1992.
GONZALEZ, L., PARADA, M. and HERNANDEZ, L. Pyridoxine acts in
the brain to reduce ethanol toxicity in rats. Alcohol, 9 (6): 519-522, 1992.
PARADA, M.A., HERNANDEZ, L., and DEGOMA, E. Serotonin may play
a role in the anorexia induced by amphetamine injections into the lateral
hypothalamus.Brain Research, 577: 218-225, 1992.
TELLEZ, S., FORGES, N., ROUSSIN, A. and HERNANDEZ, L. Coupling
of microdialysis with capillary electrophoresis: a new approach to the study of
drug transfer between two compartments of the body in freely moving rats.
Journal of Chromatography, 581: 257-266, 1992.
TOULAS, C. and HERNANDEZ, L.
fluorescence detector for Capillary Electrophoresis to measure Attomolar and
Zeptomolar amounts of compounds. Liquid Chromatography and Gas
Chromatography International, 5(3): 27-30, 1992.
TOULAS, C. and HERNANDEZ, L. A highly sensitive capillary
electrophoresis laser induced fluorescence detection method to measure
zeptomole amount of bradikinine. Analusis, 20: 49-51, 1992.
BAPTISTA, T., TENEUD, L. and HERNANDEZ, L. Enhancement of
amphetamine anorexia after chronic administration of sulpiride in rats.
Pharmacology, Biochemistry & Behavior, 45 (1): 45-49, 1993.
BAPTISTA, T., A. MATA, L. TENEUD, M. DE QUIJADA, HUI-WAN
HAN, and L. HERNANDEZ. Effects of long-term administration of clozapine
on body weight and food intake in rats. Pharmacology, Biochemistry &
Behavior, 45 (1): 51-54, 1993.
BAPTISTA, T., TENEUD, L., CONTRERAS, Q., BURGUERA, J.L.,
BURGUERA, M. and HERNANDEZ, L. Effects of acute and chronic lithium
treatment on amphetamine-induced dopamine increase in the nucleus
accumbens and prefrontal cortex in rats as studied by microdialysis.
J. Neural Transm., 94 (2): 75-89, 1993.
HERNANDEZ, L., ESCALONA, J., VERDEGUER, P. and GUZMAN,
N.A. In vivo monitoring of brain glutamate by microdialysis coupled to
capillary electrophoresis and laser induced fluorescence detection. Journal of
Liquid Chromatography, 16 (9 & 10): 2149-2160, 1993.
HERNANDEZ, L., JOSHI, N., MURZI, E., VERDEGUER, P., MIFSUD,
J.C. and GUZMAN, N. Collinear laser-induced fluorescence detector for
capillary electrophoresis. Analysis of Glutamic acid in brain dialysates. Journal
of Chromatography A, 652: 399-405, 1993.
HERNANDEZ, L., TUCCI, S., GUZMAN, N. and PAEZ, X. In vivo
monitoring of glutamate in the brain by microdialysis and capillary
electrophoresis with laser-induced fluorescence detection. Journal of
Chromatography A, 652: 393-398, 1993.
RADA, P., PARADA, M., and HERNANDEZ, L. Flexible intravenous
microdialysis probe for blood sampling in freely moving rats. Journal of
Applied Physiology, 74 (1): 466-469, 1993.
ROUSSIN, A., VERDEGUER, PH. et HERNANDEZ, L. Le couplage de la
microdialyse et de l'électrophorèse capillaire pour l'analyse in vivo. Analusis
Magazine, 21 (3): 42-45, 1993.
HERNANDEZ, L., L. GONZALEZ, E. MURZI, X. PAEZ, E.
GOTTBERG, and T. BAPTISTA.Testosterone modulates mesolimbic
dopaminergic activity in male rats. Neuroscience Letters, 171: 172-174, 1994.
SILVA, E., CATALAN, M., HERNANDEZ, L., TENEUD, L., AND
BAPTISTA, T. Hyponatremia and neuroleptic-induced obesity in rats.
Research Communications in Molecular Pathology and Pharmacology, 85
(2): 237-240, 1994.
TUCCI, S., FERNANDEZ, R., BAPTISTA, T., MURZI, E. and
HERNANDEZ, L. Dopamine increase in the prefrontal cortex correlates with
reversal of haloperidol-induced catalepsy in rats. Brain Research Bulletin, 35
(2): 125-133, 1994.
BAPTISTA, T., TENEUD, L., CONTRERAS, Q., ALASTRE, T.,
BURGUERA, J.L., BURGUERA, M. and HERNANDEZ, L. Chronic
lithium administration enhances amphetamine-induced norepinephrine increase
in the paraventricular nucleus of the hypothalamus in rats: an in vivo
microdialysis study. Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 19:
273-279, 1995.
BAPTISTA, T., L. TENEUD, Q. CONTRERAS, T. ALASTRE, J.L.
BURGUERA, M. DE BURGUERA, E. DE BAPTISTA, S. WEISS, L.
HERNANDEZ. Lithium and body weight gain.
Pharmacopsychiat.
DALHOEVEN, G.A.M., N.V. JOSHI, N. RODRIGUEZ AND L.
HERNANDEZ. Simultaneous measurements of capillary electrophoresis
fluorescence peaks and their corrersponding spectra. Journal of
Chromatography, 18 (18 & 19): 3729-3749, 1995.
DAVILA, D.F., G. BELLABARBA, L. HERNANDEZ, G. CALMON, A.
TORRES, J.H. DONIS, J. S. BARBOZA, C. LEMORVAN, J.G.
GONZALEZ. Plasma norepinephrine, myocardial damage and left ventricular
systolic function in Chagas’ heart disease. International Journal of
Cardiology, 52: 145-151, 1995.
HERNANDEZ, L. AND B.G. HOEBEL. Chronic clozapine selectively
decreases prefrontal cortex dopamine as shown by simultaneous cortical,
accumbens and striatal microdialysis in freely moving rats. Pharmacol.
Biochem. Behav., 52(3): 581-589, 1995.
JOSHI, N.V., V.O.DE JOSHI, N. RODRIGUEZ, AND L. HERNANDEZ.
Fluorescence Microscopic Spectral Study of Fluorescein and some Amino Acids.
SPIE, 2386: 303-309, 1995.
NOUADJE, G., F. COUDERC, P. PUIG, AND L. HERNANDEZ.
Combination of micellar electrokinetic chromatography and laser-induced
fluorescence detection for the determination of pressor amines and some
principal amino acids in wine. J. Capillary electrophoresis, 002(3): 117-124,
1995.
PARADA, M.A., PUIG DE PARADA, M., HERNANDEZ, L. AND
HOEBEL, B.G. Triple electrical channels on a triple fluid swivel and its use to
monitor intracraneal temperature with a thermocouple. J. Neurosci. Meth. 60:
133-139, 1995.
PARADA, M.A., PUIG DE PARADA, M., RADA, P. AND HERNANDEZ,
L. Sulpiride increases and dopamine decreases intracranial temperature in rats
when injected in the lateral hypothalamus: an animal model for the neuroleptic
malignant syndrome?. Brain Res. 674: 117-121 (1995).
PUIG DE PARADA, M., PARADA, M., AND HERNANDEZ, L. Dispogenic
effect of Pituitary Adenylciclase Activating Polipeptide (PACAP 38) injected
into the lateral hypothalamus. Brain Research, 696: 254-257, 1995.
BRIESE, E. AND L. HERNANDEZ. Ethanol anapyrexia in rats. Pharmacol.
Biochem. Behav., 54(2) 399-402, 1996.
KHOURY, A.M., D.F. DAVILA, G. BELLABARBA, J.H. DONIS,
A.TORRES, C. LEMORVAN, L. HERNANDEZ, W. BISHOP. Acute effects
of digitalis and enalapril on the neurohormonal profile of chagasic patients with
severe congestive heart failure. Int. J. Cardiology, 57: 21-29, 1996.
MAS, M., GONZALEZ-MORA, J.L., AND L. HERNANDEZ. In Vivo
Monitoring of Brain Neurotransmitter Release for the Assessment of
Neuroendocrine Interactions. Molecular and Cellular Biology, 16(3): 383-396,
1996.
MURZI, E., Q. CONTRERAS, L. TENEUD, B. VALECILLOS, M. A.
PARADA, M. PUIG DE PARADA and L. HERNANDEZ.
decreases limbic extracellular dopamine in rats. Neuroscience Letters: 202:
141-144, 1996.
OTERO DE JOSHI, V., H. GIL, S. CONTRERAS, N.V. JOSHI, AND L.
HERNANDEZ. Spectral Investigation of Somatotropin for different pH. SPIE,
2676: 284-289, 1996.
PAEZ, X., RADA, P., TUCCI, S., RODRÍGUEZ, N. and HERNANDEZ, L.
Capillary electrophoresis and laser induced fluorescence to detect amphetamine
in the brain. JOURNAL OF CHROMATOGRAPHY A. 735 (1-2): 263-269,
1996.
X. PAEZ, L. HERNANDEZ. Serotonin and 5-hydroxyindoleacetic acid
differential changes after d-norfenfluramine or fluoxetine assessed by
simultaneous brain and blood microdialysis. LIFE SCIENCES, 58: 1209-1221,
1996.
TENEUD, L.M., BAPTISTA, T., MURZI, E., HOEBEL B.G. and
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Systemic and local cocaine increase extracellular serotonin overflow in the nucleus accumbens in rats. Pharmacol. Biochem. Behav. 53(3): 747-752, 1996. 98. BAPTISTA, T., ALASTRE, T., CONTRERAS, Q., TENEUD, L.,
MARTINEZ, J.L., DE BAPTISTA, E., BURGUERA, J.L., BURGUERA,
M., & HERNANDEZ, L. Effects of lithium carbonate on reproductive
hormones in healthy men: relationship with body weight regulation. A pilot
study. Prog. Neuropsychopharmacol. Biol. Psychiat., 21: 937-950, 1997.
BAPTISTA, T., ARAUJO DE BAPTISTA, E., HERNÁNDEZ, L.,
ALTEMUS, A. & WEISS, S.R.B. Tamoxifen prevents sulpiride-induced
weight gain in female rats. Pharmacology Biochemistry and Behavior., 57 (1-
2): 215-222, 1997.
BAPTISTA, T., M.E. LOPEZ, L. TENEUD, Q. CONTRERAS, T.
ALASTRE, M. de QUIJADA, E. ARAUJO DE BAPTISTA, M.
ALTERNUS, S.R.B. WEISS, E. MUSSEO, X. PAEZ, and L HERNANDEZ.
Amantadine in the treatment of neuroleptic-induced obesity in rats: behavioral,
endocrine and neurochemical correlates. Pharmacopsychiat., 30: 43-54, 1997.
BAPTISTA, T., ALASTRE, T., CONTRERAS, Q., MARTINEZ, J.L., DE
BAPTISTA, E. & HERNANDEZ, L. Effects of antipsychotic drug sulpiride
on reproductive hormones in healthy men: relationship with body weight
regulation. Prog. Neuropsychopharmacol. Biol. Psychiat., 30: 250-255, 1997.
BAPTISTA, T., CALANCHE, L., DE QUIJADA, M., MARTINEZ, J.L.,
DE BAPTISTA, E. & HERNANDEZ, L. Effects of antipsychotic drug
sulpiride on reproductive hormones in healthy premenopausal women:
relationship with body weight regulation. Prog. Neuropsychopharmacol. Biol.
Psychiat., 30: 256-262, 1997.
BAPTISTA, T., MOLINA, M.G., MARTINEZ, J.L., DE QUIJADA, M.,
CALANCHE DE CUESTA, I., ACOSTA, A., PAEZ, X., MARTINEZ, J.M.,
& HERNANDEZ, L. Effects of the antipsychotic drug sulpiride on
reproduction hormones in healthy premenopausal women: relationship with
body weight regulation. Pharmacopsychiatry, 30: 1-7, 1997.
GUZMAN, N.A., S.S. PARK, D. SCHAUFELBERGER, L. HERNANDEZ,
X. PAEZ, P. RADA, A.J. TOMLINSON, S. NAYLOR. New approaches in
clinical chemistry: on-line analyte concentration and microreaction capillary
electrophoresis for the determination of drugs, metabolic intermediates, and
biopolymers in biological fluids. J. Chromatograpg. B: 697: 7-66, 1997.
MURZI, E., RADA, P., PUIG DE PARADA, M., PARADA, M.,
VALECILLOS, B., TILAC, C.A., and HERNANDEZ, L. Atropine decreases
drinking but not feeding and induces less hypothalamic acetylcholine-release in
diabetic rats. Brain Res., 752: 184-188, 1997.
PAEZ, X. and L. HERNANDEZ. Blood microdialysis in humans: a new
method for monitoring plasma compounds. Life Sci., 61: 847-856, 1997.
PARADA, M.A., HERNANDEZ, L., PUIG DE PARADA, M., RADA, P.
and E. MURZI. Selective action of acute systemic clozapine on acetylcholine
release in the rat prefrontal cortex by reference to the nucleus accumbens and
striatum.
J. PHARMACOL. EXP. THER. 281: 582-588, 1997.
PUIG DE PARADA, M., X. PAEZ, M. A. PARADA, L. HERNANDEZ, G.
MOLINA, E. MURZI, Q. CONTRERAS. Changes in dopamine and
acetylcholine release in the rat lateral hypothalamus during deprivation-induced
drinking. Neurosci. Lett., 227: 153-156, 1997.
RADA, P., S. TUCCI, E. MURZI and L. HERNANDEZ. Extracellular
glutamate increase in the lateral hypothalamus and decreases in the nucleus
accumbens during feeding. Brain Res., 768: 338-340, 1997.
TUCCI, S., RADA, P., SEPULVEDA, M.J., and HERNANDEZ, L.
Glutamate measured by six seconds resolution brain microdialysis: capillary
electrophoresis and laser-induced fluorescence detection application. Journal
Of Chromatography B, 694 (2): 343-349, 1997.
BAPTISTA, T., ARAUJO, H., RADA, P., & HERNANDEZ, L. Congenital
neuroblastoma in a boy born to a woman with bipolar disorder treated with
carbamazepine during pregnancy. Prog. Neuropsychopharmac., 22: 445-454,
1998.
BAPTISTA, T., CONTRERAS, Q., L. TENEUD, M.A. ALBORNOZ,
ACOSTA, A., PAEZ, X., QUIJADA, M., LACRUZ, A., & L.
HERNANDEZ. Mechanism of the neuroleptic-induced obesity in female rats.
Prog. Neuropsychopharmacol. Biol. Psychiat., 22: 187-198, 1998.
BAPTISTA, T., LACRUZ, A. and HERNANDEZ, L. Glucose tolerance and
serum insulin levels in an animal model of obesity induced by the antipsychotic
drug, sulpiride. Pharmacol. Toxicol. 83: 57-61, 1998.
PARADA, M.A., M.P. DE PARADA, L. HERNANDEZ, E. MURZI, and
B.G. HOEBEL. A multipurpose four-channel fluid swivel. Brain Res. Bull.,
45: 117-123, 1998.
PARADA, M.A., M.P. DE PARADA, L. HERNANDEZ, E. MURZI, F.
GARCIA. A practical method for simultaneous multiple intracerebral
implantations for microdialysis in rats. Brain Research Protocols, 2: 141-148,
1998.
SEPULVEDA, M.J., L. HERNANDEZ, P. RADA, S. TUCCI and E.
CONTRERAS. Effect of precipitated withdrawal on extracellular glutamate
and aspartate in the nucleus accumbens and chronically morphine-treated rats.
An in vivo microdialysis study. Pharmacol. Biochem. Behav., 60(3): 225-262,
1998.
PARADA, M., PUIG DE PARADA, M., HERNANDEZ, L. GARCIA, F.,
MURZI, E., CONTRERAS, Q. Effects of the chronic treatment with clozapine
on the clozapine-induced acetylcholine release in the rat prefrontal cortex,
nucleus accumbens and striatum. Prog. Neuropsychopharmac. & Biol.
Psychiat., 22: 1379-1397, 1998.
TUCCI, S., PINTO, C., GOYO, J., RADA, P. and HERNANDEZ, L.
Measurement of glutamine and glutamate by capillary electrophoresis and laser
induced fluorescence detection in cerebrospinal fluid of meningitis sick
children. Clin. Biochem., 31:143-150, 1998.
PÁEZ, X. AND HERNANDEZ, L. Plasma serotonin monitoring by blood
microdialysis coupled to high-performance liquid chromatography with
electrochemical detection in humans. Journal Of Chromatography B, 720: 33-
38, 1998
TUCCI, S., RADA, P. and HERNANDEZ, L. Role of glutamate in the
amygdala and Lateral Hypothalamus in conditioned taste aversion. Brain Res.,
813: 44-49, 1998.
RADA P, TUCCI S, PEREZ J, TENEUD L, CHUECOS S, HERNANDEZ
L. In vivo monitoring of gabapentin in rats: a microdialysis study coupled to
capillary electrophoresis and laser-induced fluorescence detection.
Electrophoresis. 19:2976-2980, 1998
BAPTISTA, T., REYES, D., and HERNANDEZ, L. Antipsychotic drugs and
reproductive hormones: relationship to body weight regulation. Pharmacol.
Biochem. Behav. 62: 409-417, 1999.
RADA, P. TUCCI, S., TENEUD, L., PAEZ, X., PEREZ, J., ALBA, G.,
GARCIA, Y., SACCHETTONI, S., DEL CORRAL, J. AND
HERNANDEZ, L. Monitoring G amino butiric acid in human brain and
plasma microdialysates using micellar electrokinetic chromatography and laser
induced fluorescence detection. Journal Of Chromatography B, 735: 1-10,
1999.
PAREDES, D., RADA, P., BONILLA, E., GONZALEZ, L. E., PARADA,
M. AND HERNANDEZ, L. Melatonin acts in the nucleus accumbens to
increase acetylcholine release and modify the motor activity pattern of rats.
Brain Res., 850: 14-20, 1999.
CASTEJON, A. M., PAEZ, X., HERNANDEZ, L. AND CUBEDDU, L. X.
Use of intravenous microdialysis to monitor changes in serotonin release and
metabolism induced by cisplatin in cancer patients. J. Pharmacol. & Exper.
Ther. 291: 960-966, 1999.
BAPTISTA, T., ALVAREZ, L., LACRUZ, A., DE MENDOZA, S. AND
HERNANDEZ. L. Glucose tolerance and serum insulin levels in an animal
model of obesity induced by subacute or chronic administration of anti-
psychotic drugs. Prog. Neuropsychopharmac. & Biol. Psychiat., 23: 277-287,
1999.
PAEZ, X., RADA, P. AND HERNANDEZ, L. Neutral amino acids
monitoring in phenylketonuric plasma microdialysates using micellar
electrokinetic chromatography and laser induced fluorescence detection.
Journal Of Chromatography B, 739: 247-254, 2000.
SILVA, E. HERNANDEZ, L. CONTRERAS, Q., GUERRERO, F. AND
ALBA, G. Noxious stimulation increases glutamate and arginine in the
periaqueductal gray matter in rats: a microdialysis study. Pain, 87: 131-135,
2000.
LACRUZ, A., BAPTISTA, T., DE MENDOZA, S., MENDOZA, J. M. AND
HERNANDEZ, L. Antipsychotic drug inducer obesity in rats: correlation
between leptin, insulin and body weight during sulpiride treatment. Molecular
Psychiat. 5: 70-76, 2000.
BAPTISTA, T., LACRUZ, A., DE MENDOZA, S., MENDOZA, J. M.
BURGUERA, J. L., BURGUERA, M. AND HERNANDEZ, L. Endocrine
effects of lithium carbonate in healthy premenopausal women: relationship with
body weight regulation. Prog. Neuropsychopharmac. & Biol. Psychiat., 24: 1-
16, 2000.
BAPTISTA, T., LACRUZ, A., ACOSTA, A., COLASANTE, C., DE
QUIJADA, M., DE MENDOZA, S., MENDOZA, J. M. AND
HERNANDEZ, L. Naltrexone does not prevent the weight gain and
hyperphagia induced by the antipsychotic drug sulpiride in rats. Appetite, 34:
77-86, 2000
BAPTISTA, T., LACRUZ, A., DE MENDOZA, S., MENDOZA, J. M.
SILVERA, R., ANGELES, F., MENDOZA, M. T. AND HERNANDEZ, L.
Body weight gain after administration of antipsychotic drugs: correlation with
leptin, insulin and reproductor hormones. Pharmacopsychiatry, 33: 81-88, 2000
PUIG DE PARADA, M., PARADA, M. A., RADA, P., HERNANDEZ, L.
AND HOEBEL, B. G. Dopamine-Acetylcholine interaction in the rat lateral
hypothalamus in the control of locomotion. Pharmacol. Biochem. Behav. 66:
227-234, 2000
TUCCI S, CONTRERAS Q, PAEZ X, GONZALEZ, L, RADA P,
HERNANDEZ L. Medial prefrontal transection enhance social interaction. II:
Neurochemical studies. Brain Res. 887:259-265, 2000
GONZALEZ, L. E., RUJANO, M, TUCCI, S, PAREDES, D, SILVA, E,
ALBA, G, HERNANDEZ L. Medial prefrontal transection enhances social
interaction. I: Behavioral studies. Brain Res. 887:7-15, 2000
PEREZ, J., COLASANTE, C., TUCCI, S., HERNANDEZ, L, RADA, P.
Effects of feeding on extracellular levels of glutamate in the medial and lateral
portion of the globus pallidus of freely moving rats. Brain Res. 877(1):91-4,
2000
BAPTISTA T, HERNANDEZ L, PRIETO LA, BOYERO EC, DE
MENDOZA S. Metformin in obesity associated with antipsychotic drug
administration: a pilot study. J Clin Psychiatry. 2001 Aug;62(8):653-5.
BAPTISTA T, LACRUZ A, ANGELES F, SILVERA R, DE MENDOZA S,
MENDOZA MT, HERNANDEZ L. Endocrine and metabolic abnormalities
involved in obesity associated with typical antipsychotic drug administration.
Pharmacopsychiatry. 2001 Nov;34(6):223-31.
BAPTISTA T, LACRUZ A, MEZA T, CONTRERAS Q, DELGADO C,
MEJIAS MA, HERNANDEZ L. Antipsychotic drugs and obesity: is prolactin
involved? Can J Psychiatry. 2001 Nov;46(9):829-34.
SILVA E, QUINONES B, FREUND N, GONZALEZ LE, HERNANDEZ L.
Extracellular glutamate, aspartate and arginine increase in the ventral
posterolateral thalamic nucleus during nociceptive stimulation. Brain Res.
2001 Dec 27;923(1-2):45-9.
PAEZ X AND HERNANDEZ L. Biomedical applications of capillary
electrophoresis with laser –induced fluorescence detection. Biopharmaceutics
and Drug Disposition. 2001 22: 273-289.
REYES E, ROSSELL S, PAREDES D, RADA P, TUCCI S, GONZALEZ
LE, HERNANDEZ L. Haloperidol abolished glutamate release evoked by
photic stimulation of the visual cortex in rats. Neurosci Lett. 2002 Jul
26;327(3):149-52.
BAPTISTA T, LACRUZ A, PAEZ X, HERNANDEZ L, BEAULIEU S. The
antipsychotic drug sulpiride does not affect bodyweight in male rats. Is insulin
resistance involved? Eur J Pharmacol. 2002 Jun 28;447(1):91-8.
BAPTISTA T, LACRUZ A, DE MENDOZA D, MENDOZA JM, SILVERA
R, ANGELES F, MENDOZA MT, HERNANDEZ L. Body weight gain after
administration of antipsychotic drugs. Pharmacopsychiatry. 2002 Jan;35(1):36.
RADA P, MENDIALDUA A, HERNANDEZ L, HOEBEL B. Extracellular
glutamate increases in the lateral hypothalamus during meal initiation, and
GABA peaks during satiation: microdialysis measurements every 30 sec. Behav
Neurosci. 2003 Apr;117(2):222-7.
PAEZ X, HERNANDEZ L Topical hemostatic effect of a common ornamental
plant, the geraniaceae Pelargonium zonale. J Clin Pharmacol. 2003
Mar;43(3):291-5.
GONZALEZ LE, PARADA MA, TUCCI S, TENEUD L, OVERSTREET
DH, HERNANDEZ L. A brain microdialysis study on 5-HT release in freely
moving rat lines selectively bred for differential 5-HT1A receptor function.
Braz J Med Biol Res. 2003 Feb;36(2):263-7
ROSSELL S, GONZALEZ LE, HERNANDEZ L. One-second time
resolution brain microdialysis in fully awake rats. Protocol for the collection,
separation and sorting of nanoliter dialysate volumes. J Chromatogr B Analyt
Technol Biomed Life Sci. 2003 Feb 5;784(2):385-93.
LUENGO J, ARANGUIZ T, SEPULVEDA J, HERNANDEZ L, VON
PLESSING C. Preliminary pharmacokinetic study of different preparations of
acyclovir with beta-cyclodextrin. J Pharm Sci. 2002 Dec;91(12):2593-8.
RADA, P., MORENO, SA,, GONZALEZ, LE, TUCCI, S., CHAU, DT,
HARRISON, T., HOEBEL, B.G. HERNÁNDEZ, L. Glutamate release in the
nucleus accumbens is involved in behavioral depression during the Porsolt
Swim Test. Neuroscience, 2003, 119: 557-565.
GONZALEZ LE, QUINONEZ B, RANGEL A, PINO S, HERNANDEZ L.
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA
transmission after prefrontal cortex damage in rats. Brain Res. 2004; 1005: 154-
63.
PAEZ X, MAZZEI-DAVILA CA, HERNANDEZ L. Subcutaneous
microdialysis: a simple technique for monitoring the extracellular biochemical
environment. Combination with capillary electrophoresis and laser-induced
fluorescence detection. Invest Clin. 2003;44: 227-39.
PAEZ X, HERNANDEZ L, BAPTISTA T. Advances in the molecular
treatment of depression. Rev Neurol. 2003, 37:459-70.
RANGEL A, GONZALEZ LE, VILLARROEL V, HERNANDEZ L.
Anxiolysis followed by anxiogenesis relates to coping and corticosterone after
medial prefrontal cortical damage in rats. Brain Res. 2003 Nov 28;992(1):96-
103.
SILVA E, HERNANDEZ L, QUINONEZ B, GONZALEZ LE,
COLASANTE C. Selective amino acids changes in the medial and lateral
preoptic area in the formalin test in rats. Neuroscience. 2004;124:395-404.
BARBOZA JM, MEDINA H, DORIA M, RIVERO L, HERNANDEZ L,
JOSHI NV. Use of atomic force microscopy to reveal sperm ultrastructure in
HIV-patients on highly active antiretroviral therapy. Arch Androl. 2004;
50(2):121-9.
PAEZ X, MAZZEI-DAVILA CA, QUINONEZ B, D'SUZE G,
HERNANDEZ L. Amino acid changes following intraperitoneal administration
of Tityus zulianus scorpion venom in mice. Study with subcutaneous
microdialysis and capillary electrophoresis. Invest Clin. 2003 ;44: 291-302.
BAPTISTA T, ZARATE J, JOOBER R, COLASANTE C, BEAULIEU S,
PAEZ X, HERNANDEZ L. Drug Induced Weight Gain, an Impediment to
Successful Pharmacotherapy: Focus on Antipsychotics. Current Drug Targets,
2004, 4:000-000
DIAZ-CORRALES FJ, COLASANTE C, CONTRERAS Q, PUIG M,
SERRANO J-A, HERNANDEZ L, BEAMAN BL. Nocardia otitidiscaviarum
(GAM-5) induces parkinsonian-like alterations in mouse. Braz J Med Biol Res.
2004, 37:000-000.
DMITRIEVA N, RODRIGUEZ-MALAVER AJ, PEREZ J, HERNANDEZ
L. Differential release pf neurotransmitters from superficial and deep layers of
the dorsal horn in response to acute noxious stimulation and inflamation of the
rat paw. European J. Pain. 2003 (in press).
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