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Name：tien-yu shieh

Tien-Yu Shieh
General Information：
Address: 100 Shi-Chuan 1st Road, San Ming District, Kaohsiung City.| Tel No：886-7-3121101 ext 2338 Fax No：886-7-3135340 E-mail：tiyush@kmu.edu.tw Position Title：
Director, Graduate Institute of Oral Health Research Center Kaohsiung Medical Professor, Graduate Institute of Oral Health Sciences, Kaohsiung Medical University Education：
Aichigakuin University, Nagoya, Japan Ph.D. 1981 Dentistry Kaohsiung Medical University, Kaohsiung, Taiwan D.D.S. 1970 Medicine Professional Experience
2003 - present Director, Graduate Institute of Oral Health Research Center Kaohsiung 1992 - 2003 Director, Graduate Institute of Oral Health Sciences, Kaohsiung Medical 1990 - 1992 Director, Family Dentistry Department, Kaohsiung Medical University, 1989 - present Professor, Oral and Maxillo-Facial Surgery, Kaohsiung Mdeical University, 1981 – 1989 Associate Professor, Oral and Maxillo-Facial Surgery, Kaohsiung Medical 1980 - 1981 Lecturer, Oral and Maxillo-Facial Surgery, Aichigakuin University, Nagoya, Reserch Award, National Science Council, ROC(1985-1995) Fellow, Who’s Who of the Republic of China.(1998) Who’s who in Medicine and Healthcare 2002 FICD(Fellow of International College of Dentistry) Board member of Asia-Pacific academic consortium for Public Health 2002 Current funded reserch/collaborative activities
Principal Investigator：The genetic polymorphism , and cytokines which use different treatment course of TNF-αand receptors in patients with oral Principal Investigator：The genetic polymorphism, and express of mRNA , and cytokine of TNF-α and receptors in patients with orsl squamous cell Publications：
1. Y-H Yang, C-H Chen, JSF Chang, C-C Lin, T-C Cheng, T-Y Shieh: Incidence Rates of Oral Cancer and Oral Precancercous Lessions in a 6-Year Follow-up Study of a Taiwanese Aboriginal Community. J of Oral Pathol and Med 34:596-601, 2005 2. C-M Chen, G-T Lin, Y-C Fu, T-Y Shieh, I-y Huang, Y-S Shen, C-H Chen: Complications of free radial forearn flap transfers for head and neck reconstruction. Oral Surg Oral Med O 99(6):671-6, 2005. 3. 陸洛, 李惠美, 謝天渝: 牙醫職業壓力與身心健康及職業倦怠之關係：以高雄市牙醫師為 4. C-H Chung, Y-H Yang, T-Y Wang, T-Y Shieh, Saman Warnakulasuriya: Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan. J Oral Pathol Med 34:460-6, 2005. 5. F-M Chung, Y-H Yang, C-H Chen, C-C Lin, T-Y Shieh : Angiotensin-converting enzyme gene insertion/ deletion polymorphism is associated with risk of oral precancerous lesion in betel quid chewers. British Journal of Cancer 93;602-606,2005. 6. Y-H Yang, Y-C Lien, P-S Ho, C-H Chen, JSF Chang, T-C Cheng, T-Y Shieh: The effects of chewing areca/betel quid with and without cigrette smoking on oral submucous fibrosis and oral mucosal lesions. Oral Diseases 11;88-94,2005. 7. T-C Lin, T-Y Shieh, Y-M Wu: A study on the Relation Between Oral Health and General Health Conditions. 安泰醫護雜誌 11(2):69-77, 2005. 8. C-W Wu, C-H Chen, I-Y Huang, T-Y Shieh: Outcomes of Primary Oral Squamous Cell Carcinoma after Treatment in Female Patients without Bad Oral Habits. Chin J Oral Maxillofac Surg 16:30-35, 2005. 9. C-M Chen, Y-C Chen, C-H Chen, T-Y Shieh: Tibia bone graft in the alveolar cleft：case report. Taiwan J Oral Med Health Sci 20:23-30, 2004. 10. P-H Chen, Y-C Ko, Y-H Yang, Y-C Lin, T-Y Shieh, C-H Chen, C-C Tsai: Important prognostic factors of long-term oropharyngeal carcinoma survivors in Taiwan. Oral Oncology 40:847-855, 2004. 11. C-M Chen, C-F Yang, I-Y Huang, Y-S Shen, T-Y Shieh, C-H Chen, H-E Lee: Clinical evaluation of a new bilayer artificial dermis for repair of oral mucosal defects：report of two cases. Kaohsiung J Med Sci 20:516-520, 2004. 12. I-T Chiang, Y-H Yang, T-Y Shieh. A Study of Caries and Its Affecting Factors of Kindergarten Children in Yen Chau Village. Taiwan J Oral Med Health Sci 20(2); 48-60, 2004 13. C-Y Liang, T-M Chou, P-S Ho, T-Y Shieh, Y-H Yang. Prevalence rates of alcohol drinking in Taiwan. Taiwan J Oral Med Health Sci 20(2); 91-104, 2004
14. T-R Su, K-L Chang, C-H Lee, C-H Chen, Y-H Yang, T-Y Shieh: Expression of tumor necrosis factor-alpha and its soluble receptors in betel-quid-chewing patients at different stages of treatment for oral squamous cell carcinoma. Oral Oncology 40;804-810,2004. 15. C-H Chung, Y-H Yang, T-T Chang, D-B Shieh, S-Y Liu, T-Y Shieh: Relationship of Oral Lichen Planus to Hepatitis C Virus in Southern Taiwan. Kaohsiung J Med Sci 20;151-9, 2004. 16. D-H Shieh, L-C Chiang, C-H Lee, Y-H Yang, T-Y Shieh: Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan. J Oral Pathol Med 33;581-7,2004. 17. H-J Hsu, I-Y Huang, C-M Chen, J-F Yang, Y-S Shen, T-Y Shieh, S Lai, H-R Chen, Chung-H Chen. A Study of the Hospitalization Patterns in Children of the Department of Oral and Maxillofacial Surgery. Chin J Oral Maxillofac Surg 14: 105-118, 2003. 18. G-L Hou, C-C Hung, Y-H Yang, Y-C Chen, T-Y Shieh, C-C Tsai：Radiographic alveolar Bone Loss in Untreated Taiwan Chinese Subjects with Adult Periodontitis measured by the digital scanning radiographic image analysis method. Dento Maxillo Facial Radiology 32:104-108,2003 19. C-H Chung, T-Y Wong, T-Y Shieh, D-B Shieh, S-C Chao: Nevoid Basal Cell Carcinoma Syndrome-Clinical Manifestations and Mutation Analysis of a Taiwanese Family. J Formos Med Assoc 102;793-7,2003. 20. D-H Shieh, L-C Chiang, T-Y Shieh: Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. Oral Oncology 39;728-735,2003. 21. T-C Ma, T-Y Shieh, Y-H Yang: Thel Relationship of the Oral Care Behavior with Dental Caries and Periodontal Disease of Environmental workers. Taiwan J Oral Med Health Sci 19(2);48-57,2003. 22. B-C Wu, T-Y Shieh, Y-H Yang: AStudy of Residents’ Oral Health Behaviors in Yunlin County. Taiwan J Oral Med Health Sci 19(2);24-33,2003. 23. G-L Hou, C-C Hung, Y-H Yang, C-C Tsai, P-H Chen, T-Y Shieh: Topographic Study of Extracted Molars with Advanced Furcation Involvement: Furcation Entrance Dimension and Molar Type. Kaohsiung J Med Sci 19: 68-74, 2003. 24. Y-C Chen, C-C Hung, Y-H Yang, C-C Tsai, T-Y Shieh , G-L Hou: Root Trunk Type Correlated with Extracted Molars Affected by Class III Furcation Involvemetn. Taiwan J Oral Med Health Sci 19(1);48-55,2003. 25. S-W Chang, K-L Chang, H-R Chen, C-H Chen, Y-H Yang, I-Y Huang, Y-H Kao, T-Y Shieh: mRNA Expression of TNF-α, TGF-β and IFN-γ Cytokines in Peripheral Blood Mononuclear Cells in Patients with Oral Submucous Fibrosis and Leukoplakia: Taiwan J Oral Med Health Sci 19(1);37-47,2003. 26. S-T Shieh, Y-A Cheng, T-Y Shieh, S-Y Huang: The Investigation of Work Situation and Demend for Dental Auxiliaries. Taiwan J Oral Med Health Sci ;19(1):26-36,2003. 27. C-H Tseng, T-Y Shieh,Y-H Yang: Oral Health Behavior in Taiwan. Taiwan J Oral Med Health 28. Y-C Tseng, C Pan, Y-H Yang, T-Y Shieh, W-C Ou-Yang : Oral Health Status in Hospitalized Psychiatric Patients. Taiwan J Oral Med Health Sci 2003;19(1):1-12. 29. D-H Shieh, L-C Chiang, T-Y Shieh: Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. Oral Oncology 39:728-735, 2003. 30. C-H Lee, Y-C Ko, H-L Huang, Y-Y Chao, T-Y Shieh, L-M Lin: The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan. British Journal of Cancer 88(3):366-372, 2003. 31. G-L Hou, C-C Hung, Y-H Yang, Y-C Chen, C-C Tsai, T-Y Shieh: Periodontal Bone Loss in Chinese Subjects with Untreated Early-Onset and Adult Periodontitis:A Cross-sectional Study Using Digital Scanning Radiographic Image Analysis. Kaohsiung J Med Sci 18: 500-507, 2002. 32. C-H Lee, S-J Lan, T-Y Shieh. The distribution of dental resources under nation health in Kaohsiung and Pingtung area. Taiwan J Oral Med Health Sci 2002;18:56-67. 33. Y-P Chen, S-J Lan, T-Y Shieh. The re-filling distribution for dental caries in Kaohsiung and Pingtung area. Taiwan J Oral Med Health Sci 2002;18:48-55. 34. C-H Pan, Y-J Horng, Y-H Yang, T-Y Shieh .A study of dental carues of kindergartens children in Taiwan city. Taiwan J Oral Med Health Sci 2002;18:39-50. 35. C-Y Cheng, Y-H Yang, Y-J Hong, T-Y Shieh. The study of oral condition with oral hygiene knowledge,attitude and practice of university students in Kaohsiung city. Taiwan J Oral Med Health Sci 2002;18:27-38. 36. C-W Wu, K-L Chang, H-R Chen, T-Y Shieh: Detection of human papillomavirus and Epstein-Barr virus oral squamous cell carcinoma by using the polymerase chain reaction method. Taiwan J Oral Med Health Sci 2002;18:17-26 37. Y-H Yang, H-R Chen, C-H Tseng, T-Y Shieh: Prevalence rates of areca/betel hewing in counties of Taiwan.Taiwan J Oral Med Health Sci 2002;18:1-16 38. M-J Chen,Y-H Yang, T-Y Shieh: Evalution of a self-rating screening test for areca quid abusers in Taiwan. Public Health 2002;116:195-200. 39. P-S Ho, Y-C KO, Y-H Yang, T-Y Shieh, C-C Tsai. The incidence of oropharyngeal cancer in Taiwan:an endemic betel quid chewing area. J Oral Pathol Med 2002:31:231-9 40. C-M Chen, C-H Chen, T-Y Shieh, G-T Lin, H-E Lee: L-Extension Deltopectoral Flap in Head and Neck Reconstruction. Chin J Oral Maxillofac Surg 12:8-16, 2001. 41. H-J Hsu, K-L Chang, Y-H Yang, T-Y Shieh: The Effects of Arecoline on the Release of Cytokines Using Cultured Peripheral Blood Mononuclear Cells from Patients with Oral Mucous Diseases. Kaohsiung J Med Sci 17：175-182,2001. 42. S-W Chang, C-H Chen, T-Y Shieh, C-S Lee: The Dental Treatment in Patients with Hypertension. J Academy Formosan Stomatology 17：66-73,2001. 43. C-Y Liang, Y-H Yang, T-Y Shieh: The Study of Oral Condition and Oral Health Knowledge, Attitude, Practice of the Aged in Senior Citizen Recreation Center. J Academy Formosan 44. J-D Huang, Y-H Yang, T-Y Shieh: An investigation of the knowledge and attitude to the facilities of emergency rescue care of dental clinics. J Academy Formosan Stomatology 17：15-28,2001. 45. Y-A Cheng, C-C Cheng, C-C Tsai, Y-H Yang, T-Y Shieh: Betel-quid chewing behavior related to precancerous oral lesions in Manchou country, Taiwan. J Academy Formosan Stomatology 17：1-14,2001. 46. Y-H Yang, H-Y Lee, T Sen, T-Y Shieh: Epidemiological survey of oral submucous fibrosis and leukoplakia in aborigines of Taiwan. J Oral Pathol Med 30:213-9, 2001. 47. G-L Hou, C-H Lin, C-C Hung, Y-H Yang, T-Y Shieh, I-C Lin, C-C Tsai: The consistency and reliability of periodontal bone level measurements using digital scanning radiographic image analysis-s pilot study. Kaohsiung J Med Sci 16: 566-573, 2000. [國科會資助優良期刊] 48. Y-A Cheng, L-F Shiue, H-S Yu, T-Y Shieh, C-C Tsai: Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments. Kaohsiung J Med Sci 16: 126-133, 2000. 49. Y-W Shiau, Y-H Yang, T-Y Shieh: The effect of betel quid chewing on oral mucosal lesion-meta analysis. J Academy Formosan Stomatology 16: 296-313, 2000. 50. Y-C Lin, E Ko, T-Y Shieh: A study on mutagenicity of betel quid ingredients. J Academy 51. C-M Chen, T-Y Shieh: Treatment of cleft palate in an adult patient—a case report. Chin J Oral 52. C-C Tsai, C-C Chen, C-C Lin, C-H Chen, T-S Lin, T-Y Shieh: Interleukin-1β in oral submucous fibrosis, verrucous hyperplasia and squamous cell carcinoma tissues. Kaohsiung J. Med. sci. 15(9): 513-9, 1999 53. C-W Lin, C-H Chen, Y-H Yang, T-Y Shieh: A retrospective study of DNA ploidy of oral squamous cell carcinomas using laser flow cytometry.Chin Dent J 18: 91-100, 1999. 54. C-C Tsai, R-H Ma, T-Y Shieh: Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis. J Oral Pathol Med 28: 59-63, 1999. 55. C-L Huang, I-Y Huang, T-Y Shieh: Assessment of psychological profiles of the patients with tempormoandibular disorder. J Academy Formosan Stomatology 15: 240-249, 1999. 56. C-H Huang, T-Y Shieh: Immunohistochemical expression of transforming growth factor in oral submucous fibrosis. J Academy Formosan Stomatology 15: 227-239,1999. 57. C-J Chen, J Kang, T-Y Shieh: Changes in lysyl oxidase activity and calcium content during the healing of tooth extraction wounds: Kaohsiung J. Med. sci. 13: 432-439, 1997. (NSC 80-0412-B-037-71). 58. J-M Hong, T-Y Shieh, C-H Chen: Squamous Cell Carcinoma of the Pouch of Hamster Treated with Cisplatin-Using Flow Cytometry. Chin J Oral Maxillofac Surg 8(1):1-13, 1997. 59. C-Y Hwang, T-Y Shieh: Study on fluoride intake from beverage consumption in primary schoolchildren of Kaohsiung city. J. Dent. sci. 16: 131-135, 1996. 60. I-C Lin, G-L Hou, T-Y Shieh, C-C Tsai: A cross-sectional radiographic study of proximal alveolar bone loss in molars with adult periodontitis. Kaohsiung J. Med. sci. 12: 716-727, 1996. 61. G-L Hou, I-C Lin, C-C Tsai, T-Y Shieh: The study of molar furcation involvements correloted with age, in adult periodontitis of chinese population sex and alveoh bone loss. Kaohsiung J. Med. sci. 12: 514-521, 1996. 62. T-S Lin, T-Y Shieh: Levels of 1L-1β of Oral Mucosal Lesions and Normal Oral Mucosa. Chin 63. Y-H Shen, T-Y Shieh: The application of Moir‘e topography in analysis of face among young Taiwanese adults. Kaohsiung J. Med. Sci. 11: 339-352, 1995.(NSC 79-0412-B037-47) 64. R-H Ma, C-C Tsai, T-Y Shieh: Increased lysyl oxidase activity in fibroblasts cultrues from oral submucous fibrosis associated with betel nut chewing in Taiwan J Oral Pathol Med 24: 407-412, 1995.[SCI] 65. T-Y Shieh, J-F Yang: Collagenase activity in oral submucous fibrosis Proceedings of the National Science Counil. R.O.C. Part B: Life Sciences 16(2): 106-110, 1992.(NSC 78-0412-B037-36) 66. P-H Chiang, C-P Chiang, M-R Shen, C-H Hung, C-J Wang, I-Y Huang, T-Y Shieh: Strdy of the changes in collagen of the tunica albuginea in venogenic impotence and Peyronie‘s disease. Eur. Urol. 21: 48-51, 1992.[SCI] 67. H-J Chen, C-H Wang, C-C Wang, T-Y Shieh: A modified technique of obturator fabrication for cleft palate infants. Kaohsiung J. Med. Sci. 6: 546-550, 1990. 68. S-S Liao, T-Y Shieh: A study of the growth change of the alveolar arch in Chinese infants. Kaohsiung J Med Sci 6(4): 168-180, 1990. 69. I-Y Huang, T-Y Shieh: Collagen content and types in oral submucous fibrosis. Kaohsiung J 70. T-Y Shieh, L-Y Lin, C-C Chang: A study of the changes in collagen content and type and their relationship to calcium in bone healing. Kaohsiung J. Med. Sci 4: 606-615, 1988. (NSC 76-0412-8037-32) 71. L-Y Lin, T-Y Shieh, C-C Chang: Isolation and characterization of the hydroxyapatite-binding proteins from hunam whole saliva. Kaohsiung J. Med. Sci. 4: 23-33, 1988. 72. T-Y Shieh, C-C Chen: A study of facial growth and development of children II:study of the lateral view. Kaohsiung J. Med. Sci. 3: 326-337, 1987. 73. T-Y Shieh, C-C Chen: A study of facial growth and development of children I: study of the front view Kaohsiung Med. Sci. 2(6): 371-393, 1986. 74. Y. K. Hashimoto, T-Y Shieh, H. S. Aoyamam , Y. H. Izawa, T. R. Hayakawa: Isolation and characterization of type V collagen from human post-burn granulation tissues. J. Investigative Dermatology. 87(4): 540-543, 1986.[SCI] 75. T-Y Shieh, Y. K. Hashimoto, T. R. Hayakawa, K. I. Kurita, T. Kawai: Changes in collagen content and collagen types during repair of mandibular defects. Aichi-Gakuin J. Dent. Sci. 23(4): 371-393, 1986. 76. I-Y Huang, T-Y Shieh: Unilaterally congenital dimple of the upper lip-a case study. Kaohsiung 77. J-F Yang, T-Y Shieh, C-C Lin: Congenital complex odontoma-report of a case Kaohsiung J. 78. T-Y Shieh, D-R Lai: A study on whole embryo culture of head-fold rat embryos to the organogenesis. Chinese Dental J. 3(2): 34-40, 1984.(NSC 72-0412-B037-R07) 79. T-Y Shieh, D-R Lai: Oral-facial-digital syndrome: report of two cases. Chinese Dental J. 3(1): 80. D-R Lai, T-Y Shieh, C-C Lin. Intraoral nevi: review of the literature and report of four cases. 81. T-Y Shieh, R. J. Chen, C-C Lin: Scheannoma of the tongue: report of a case. Chinese Dental J. 82. T Kaiwai, T-Y Shieh, M. H. Abe, T Yamamoto: A study on morphology of bilateral cleft lip. J. Japan Cleft Palate Asociation 6(1): 29-50. 1981. 83. T-Y Shieh: A strdy on morphology of unilateral cleft lip (especially the deformities of the face due to types of clefts) J. Japan Cleft Palate Association. 5(2): 91-122, 1981. 84. M. N. Ohnishi, F. O. Hotta, M. H.Hinoshita, T-Y Shieh, T Kawai., N. Y. Ogawa.: The clinical anti-inflammatory effect of Piroxicam in post exodontic or postoperative inflammation-A doubt-blind study-Japan J. Oral surg. 27(6): 786-800, 1981. 85. M. N. Ohnishi, F. O. Hotta, T. H. Kataura, M.N. Miura, T-Y Shieh, N. Y. Ogawa : The clinical effect of Poroxicam on postexodontic or postoperative pain-A doubt-blind study-Japan J. Oral Surg. 27(4): 532-540, 1981. 86. T Kawai, K I Kurita, O Hashimoto, S Oriya, M N Ohnishi, T-Y Shieh, S Tanida, Y. Kameyama: A case of pigmentation due to deposition of bismuth. Japan. J. Oral Surg. 26(5): 1280-1282, 1980. 87. T Kawai, T Yamamoto, M-H Abe, T-Y Shieh, T Tomi , M Yokota : The use of a denuded muscle flap of vermilion in the repair of cleft lip. Japan. J. Oral Surg. 22(5): 670-673, 1980.

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