1. Herrmann MK, Kertesz T, Gsänger T, Bloch E, Pollul G, Bouabdallaoui M,
Strauss A, Herrmann M, Christiansen H, Wolff HA, Hess CF, Hille A. Gold marker displacement due to needle insertion during HDR-brachytherapy for treatment of prostate cancer: a prospective cone beam computed tomography and kilovoltage on-board imaging (kV-OBI) study. Radiat Oncol. 2012 Feb 20;7:24.
2. Schirmer MA, Brockmöller J, Rave-Fränk M, Virsik P, Wilken B, Kühnle E,
Campean R, Hoffmann AO, Müller K, Goetze RG, Neumann M, Janke JH, Nasser F, Wolff HA, Ghadimi BM, Schmidberger H, Hess CF, Christiansen H, Hille A. A putatively functional haplotype in the gene encoding transforming growth factor beta-1 as a potential biomarker for radiosensitivity. Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):866-74.
3. Wolff HA, Rolke D, Rave-Fränk M, Schirmer M, Eicheler W, Doerfler A,
Hille A, Hess CF, Matthias C, Rödel RM, Christiansen H. Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Radiat Environ Biophys. 2011 Mar;50(1):145-54.
4. Herrmann MK, Bloch E, Overbeck T, Koerber W, Wolff HA, Hille A,
Vorwerk H, Hess CF, Muller M, Christiansen H, Pradier O. Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC--treatment results after long-term follow-up and literature overview. Cancer Radiother. 2011 Apr;15(2):81-8.
5. Wolff HA, Raus I, Jung K, Schüler P, Herrmann MK, Hennies S, Vorwerk H,
Hille A, Hess CF, Christiansen H. High-grade acute organ toxicity as a positive prognostic factor in primary radiochemotherapy for anal carcinoma. Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1467-78.
6. Hille A, Grüger S, Christiansen H, Wolff HA, Volkmer B, Lehmann J, Dörr
W, Rave-Fränk M. Effect of tumour-cell-derived or recombinant keratinocyte growth factor (KGF) on proliferation and radioresponse of human epithelial tumour cells (HNSCC) and normal keratinocytes in vitro. Radiat Environ Biophys. 2010 May;49(2):261-70.
7. Hille A, Hofman-Hüther H, Kühnle E, Wilken B, Rave-Fränk M,
Schmidberger H, Virsik P. Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients. Radiat Environ Biophys. 2010 Mar;49(1):27-37.
8. Wolff HA, Rödel RM, Gunawan B, Overbeck T, Herrmann MK, Hennies S,
Hille A, Vorwerk H, Matthias C, Hess CF, Christiansen H. Nasopharyngeal carcinoma in adults: treatment results after long-term follow-up with special reference to adjuvant interferon-beta in undifferentiated carcinomas. J Cancer Res Clin Oncol. 2010 Jan;136(1):89-97.
9. Kertesz T, Herrmann MK, Zapf A, Christiansen H, Hermann RM, Pradier O,
Schmidberger H, Hess CF, Hille A. Effect of a prostaglandin--given rectally for prevention of radiation-induced acute proctitis--on late rectal toxicity. Results of a phase III randomized, placebo-controlled, double-blind study. Strahlenther Onkol. 2009 Sep;185(9):596-602.
10. Christiansen H, Wolff HA, Knauth J, Hille A, Vorwerk H, Engelke C, Rödel
R, Laskawi R.[Radiotherapy : an option for refractory salivary fistulas].HNO. 2009 Dec;57(12):1325-8.
11. Moriconi F, Malik I, Ahmad G, Dudas J, Rave-Fränk M, Vorwerk H, Hille A, Hess CF, Ramadori G, Christiansen H. Effect of irradiation on gene expression of rat liver adhesion molecules: in vivo and in vitro studies. Strahlenther Onkol. 2009 Jul;185(7):460-8.
12. Mildner A, Mack M, Schmidt H, Brück W, Djukic M, Zabel MD, Hille A,
Priller J, Prinz M. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain. 2009 Sep;132(Pt 9):2487-500.
13. Herrmann MK, Gsänger T, Strauss A, Kertesz T, Wolff HA, Christiansen H,
Vorwerk H, Hess CF, Hille A. The impact of prostate volume changes during external-beam irradiation in consequence of HDR brachytherapy in prostate cancer treatment. Strahlenther Onkol. 2009 Jun;185(6):397-403.
14. Hille A, Rave-Frank M, Christiansen H, Herrmann MK, Kertesz T, Hermann
RM, Wolff HA, Schirmer M, Hess CF, Ramadori G. Faecal calprotectin and lactoferrin values during irradiation of prostate cancer correlate with chronic radiation proctitis: Results of a prospective study. Scand J Gastroenterol. 2009 Jun 6:1-8.
15. Olthoff A, Ewen A, Wolff HA, Hermann RM, Vorwerk H, Hille A, Rödel R,
Hess CF,Steiner W, Pradier O, Christiansen H. Organ function and quality of life aftertransoral laser microsurgery and adjuvant radiotherapy for locally advanced laryngeal cancer. Strahlenther Onkol. 2009 May;185(5):303-9.
16. Wolff H, Overbeck T, Roedel R, Hermann R, Herrmann M, Kertesz T,
Vorwerk H, Hille A, Matthias C, Hess C, Christiansen H (2009) Toxicity of daily low dose cisplatin in radiochemotherapy for locally advanced head and neck cancer. J CANCER RES CLIN, 135(7): 961-7.
17. Hille A, Schmidt-Giese E, Hermann RM, Herrmann MK, Rave-Fränk M,
Schirmer M, Christiansen H, Hess CF, Ramadori G (2008) A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation
18. Hille A, Herrmann MK, Kertesz T, Christiansen H, Hermann RM, Pradier O,
Schmidberger H, Hess CF. Sodium butyrate enemas in the treatment of acute radiation-induced proctitis in patients with prostate cancer and the impact on late proctitis. A prospective evaluation. Strahlenther Onkol. 2008 Dec;184(12):686-92
19. Christiansen H, Saile B, Hermann RM, Rave-Fränk M, Hille A,
Schmidberger H, Hess CF, Ramadori G (2007) Increase of hepcidin plasma and urine levels is associated with acute proctitis and changes in hemoglobin levels in primary radiotherapy for prostate cancer. J CANCER RES CLIN, 133(5): 297-304.
20. Christiansen H, Sheikh N, Saile B, Reuter F, Rave-Fränk M, Hermann RM,
Dudas J, Hille A, Hess CF, Ramadori G (2007) x-Irradiation in rat liver: consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. RADIOLOGY, 242(1): 189-97.
21. Hermann RM, Fest J, Christiansen H, Hille A, Rave-Fränk M, Nitsche M,
Gründker C, Viereck V, Jarry H, Schmidberger H (2007) Radiosensitization dependent on p53 function in bronchial carcinoma cells by the isoflavone genistein and estradiol in vitro. STRAHLENTHER ONKOL, 183(4): 195-202.
22. Hermann RM, Schwarten D, Fister S, Grundker C, Rave-Frank M, Nitsche
M, Hille A, Thelen P, Schmidberger H, Christiansen H (2007) No supra- additive effects of goserelin and radiotherapy on clonogenic survival of prostate carcinoma cells in vitro. RADIAT ONCOL
23. Hermann RM, Horstmann O, Haller F, Perske C, Christiansen H, Hille A,
Schmidberger H, Füzesi L (2006) Histomorphological tumor regression grading of esophageal carcinoma after neoadjuvant radiochemotherapy: which score to use? DIS ESOPHAGUS, 19(5): 329-34.
24. Christiansen H, Hermann RM, Martin A, Florez R, Kahler E, Nitsche M,
Hille A, Steiner W, Hess CF, Pradier O (2006) Long-term follow-up after transoral laser microsurgery and adjuvant radiotherapy for advanced recurrent squamous cell carcinoma of the head and neck. INT J RADIAT ONCOL, 65(4): 1067-74
25. Hille A, Töws N, Hess CF (2006). A comparison of three-field and four-field
techniques in different clinical target volumes in prostate cancer irradiation using dose volume histograms: a prospective three-dimensional analysis. BRIT J RADIOL, 79(938): 148-57.
26. Christiansen H, Hermann RM, Hille A, Schmidberger H, Martin A, Nitsche
M, Hess CF, Pradier O (2005) Phase I study of continuous mitomycin-C infusion in concomitant radiochemotherapy of primary inoperable advanced head and neck cancer. J CANCER RES CLIN, 131(12): 815-20.
27. Hermann RM, Henkel K, Christiansen H, Vorwerk H, Hille A, Hess CF,
Schmidberger H (2005) Testicular dose and hormonal changes after radiotherapy of rectal cancer. RADIOTHER ONCOL, 75(1): 83-8.
28. Hille A, Christiansen H, Pradier O, Hermann RM, Siekmeyer B, Weiss E,
Hilgers R, Hess CF, Schmidberger H (2005) Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis. STRAHLENTHER ONKOL, 181(9): 606-14.
29. Hille A, Schmidberger H, Hermann RM, Christiansen H, Saile B, Pradier O,
Hess CF (2005) A phase III randomized, placebo-controlled, double-blind study of misoprostol rectal suppositories to prevent acute radiation proctitis in patients with prostate cancer. INT J RADIAT ONCOL, 63(5): 1488-93.
30. Hille A, Schmidberger H, Töws N, Weiss E, Vorwerk H, Hess CF (2005)
The impact of varying volumes in rectal balloons on rectal dose sparing in conformal radiation therapy of prostate cancer. A prospective three-dimensional analysis. STRAHLENTHER ONKOL, 181(11): 709-16.
31. Hille A, Töws N, Schmidberger H, Hess CF (2005) A prospective three-
dimensional analysis about the impact of differences in the clinical target volume in prostate cancer irradiation on normal-tissue exposure. A potential for increasing the benefit/risk ratio. STRAHLENTHER ONKOL, 181(12): 789-795.
32. Pradier O, Lederer K, Hille A, Weiss E, Christiansen H, Schmidberger H,
Hess CF (2005) Concurrent low-dose cisplatin and thoracic radiotherapy in patients with inoperable stage III non-small cell lung cancer: a phase II trial with special reference to the hemoglobin level as prognostic parameter. J CANCER RES CLIN, 131(4): 261-9.
33. Pradier O, Lederer K, Hille A, Weiss E, Christiansen H, Hess CF (2005):
Concurrent low-dose cisplatin and thoracic radiotherapy in patients with inoperable stage III non-small cell lung cancer: a phase II trial with special reference to the hemoglobin level as prognostic parameter. J Cancer Res Clin Oncol 131, 261-9.
34. Weiss E, Vorwerk H, Keall PJ, Pradier O, Christiansen H, Hille A, Hess CF
(2005) Letter to the editor concerning Senan et al., [Radiother Oncol 2004;71:139-146]. RADIOTHER ONCOL, 74(3): 346-7.
35. Weiss E, Vorwerk H, Keall PJ, Pradier O, Christiansen H, Hille A, Hess CF
(2004): Letter to the editor concerning Senan et al. Radiother Oncol 71,139-146.
36. Christiansen H, Hermann RM, Hille A, Weiss E, Nitsche M, Martin A, Hess
CF, Pradier O (2004). Concomitant radiochemotherapy in primary inoperable advanced head and neck cancer with 5-fluorouracil and mitomycin-C. Head Neck 26, 845-53.
37. Hille A, Weiss E, Hess CF (2003): Therapeutic outcome and prognostic
factors in the radiotherapy of recurrences of cervical carcinoma following surgery. Strahlenther Onkol 179, 742-7.
38. Hille A, Rave-Frank M, Pradier O, Damm C, Dorr W, Jackel MC,
Christiansen H, Hess CF, Schmidberger H (2003): Effect of keratinocyte growth factor on the proliferation, clonogenic capacity and colony size of human epithelial tumour cells in vitro. Int J Radiat Biol 79, 119-28.
39. Weiss E, Richter S, Krauss T, Metzelthin SI, Hille A, Pradier O, Siekmeyer
B, Vorwerk H, Hess CF (2003): Conformal radiotherapy planning of cervix carcinoma: differences in the delineation of the clinical target volume. A comparison between gynaecologic and radiation oncologists. Radiother Oncol 67, 87-95.
40. Schmidberger H, Rave-Frank M, Kim S, Hille A, Pradier O, Hess CF (2003):
Radiation-induced mucositis and neutrophil granulocytes in oral mucosa. Strahlenther Onkol 179, 667-72.
41. Pradier O, Hille A, Schmidberger H, Hess CF (2002): Monitoring of therapy
in head and neck patients during the radiotherapy by measurement of Cyfra 21-1. Cancer Radiother 6, 15-21.
42. Pradier O, Hille A, Schmidberger H, Hess CF (2001): The role of high-
energy imaging in a radiotherapy service and its incorporation in a network. Cancer Radiother 5, 246-54.
43. Busch M, Rave-Frank M, Hille A, Duhmke E (1998): Influence of clodronate
on breast cancer cells in vitro. Eur J Med Res 3, 427-31.
THERAPEUTISCHES DRUG MONITORING - TDM Im Unterschied zur Drogenanalytik, bei der der Einsatz von breiten Gruppen-Screeningtests zur Erfassung von Substanzen und deren relevanten Metabolite erwünscht ist, sollte in der Medikamentenanalytik die immunologische Nachweismethode präzise, richtig und spezi- fisch sein. Die Erfassung von Metaboliten ist hier in der Regel nicht erwünscht. Das ve
Quantitative evaluation of drug transport and metabolism in the body Research Department of Genetic, Evolution and Environment, University College London (UCL), London, United Kingdom Professor Yuichi Sugiyama Associate Professor Hiroyuki Kusuhara Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo Abstract